Core C: Metabolic Phenotyping Core

摘要/摘要 目前的计划的目标是进一步了解分子机制内， 控制心脏代谢的大脑。目前的核心旨在提供技术和 为所有四个项目采用的小鼠模型的能量稳态评估提供智力支持 在程序中。通过这一核心，项目将获得一系列用于评估的设备， 能量稳态，包括多重系统（Promethion，OxyMax），基于NMR的身体成分 分析仪，弹式热量计，代谢笼系统，呼吸计，直接热量计，细胞 呼吸系统、尿液分析/血液分析系统等。此外，核心工作人员将提供手术支持 PI将为所有项目提供统计支持和培训。将这些集中起来 将终点纳入核心将支持所有代谢表型数据的严格性和重现性， 节目

Summary / Abstract The objective of the current program is to further our understanding of the molecular mechanisms within the brain that contribute to cardiometabolic control. The current core is designed to provide technical and intellectual support for assessments of energy homeostasis in mouse models employed by all four projects within the program. Through this core, projects will have access to an array of equipment used to assess energy homeostasis including multiplexed systems (Promethion, OxyMax), NMR-based body composition analyzers, bomb calorimeters, metabolic caging systems, respirometers, direct calorimeters, cellular respiration systems, urinalysis/blood analysis systems, etc. In addition, core staff will provide surgical support for all projects, and the PI will provide statistical support and training for all projects. The centralizing of these endpoints into a core will support increased rigor and reproducibility of all metabolic phenotyping data across the program.