Arkansas Center for Food Allergy Research (ArCOFAR)

项目总结 食物过敏是一种具有全球性影响的疾病，与危及生命的反应有关， 治疗和预防的选择有限。尽管研究取得了重大进展，但仍有许多 在全球实施有效的治疗和预防方案之前必须解决问题 受食物过敏影响的患者可以认识到。食物过敏研究联盟(COFAR)是 成立的目的是通过其临床研究合作研究网络来解决这些悬而未决的问题 在食物过敏临床试验方面具有经验和专业知识的单位(CRU)。为此，阿肯色州中心 食物过敏研究(ArCOFAR)建立在30年卓越、专业知识和领导能力的基础上 在食物过敏方面，并准备立即满足COFAR的总体计划目标。这个 ArCOFAR站点通过我们广泛的研究贡献，处于作为COFAR CRU的理想位置 经验，并利用我们人口独特的地理和耐心的人口统计特征。 我们的努力将以以下中心假设为指导，即ArCOFAR将使不同的 一群食物过敏的个体，在最高质量的创新临床试验中进行专业设计 和科学价值。我们的首要目标是提供一个独特的研究平台，以显著提高 食物过敏儿童和成人的生活。这一目标将通过设计和 通过高质量、高影响的研究实施创新的临床研究和治疗试验 协作。我们的假设将通过执行四个具体目标来检验：1)利用既定的专业知识 以食物过敏研究为平台，通过以下途径扩大免疫疗法的临床试验开发 与其他Cofar CRU进行综合研究；2)利用机构和社区资源进行扩展 ArCOFAR CRU在食物过敏方面的人口研究能力，包括参与出生队列 和纵向成果研究；3)将现有的机构间和机构内资源联系起来，以扩大 参与临床研究，包括更多样化的食物过敏患者；4)促进职业生涯 通过积极招募和指导新的食物过敏研究人员发展新的和早期的职业生涯 并链接已建立的计划和网络资源。此外，我们的尖端临床试验 核桃口服免疫疗法将解决树木坚果过敏管理中未得到满足的需求。此外， ArCOFAR的多学科团队在食物过敏方面拥有成熟的专业知识和国际领先地位 临床试验，将通过开发和测试新的免疫疗法来扩大临床研究 和实施队列研究，同时向早期提供指导和职业发展机会 和新的职业调查员。这项提议的结果将是改善儿童和成年人的健康 在阿肯色州及其他地区与食物过敏的合作，同时推进Cofar的使命，从根本上改变 食物过敏领域。

PROJECT SUMMARY Food allergy is a disease of global impact associated with life-threatening reactions, increasing prevalence, and limited options for treatment and prevention. Despite significant research advances, many remaining questions must be addressed before global implementation of impactful therapeutic and prevention options for patients affected by food allergy can be realized. The Consortium for Food Allergy Research (CoFAR) was formed to address these unresolved questions through its collaborative research network of Clinical Research Units (CRU) with experience and expertise in food allergy clinical trials. To this end, the Arkansas Center for Food Allergy Research (ArCOFAR) builds on a >30 year foundation of excellence, expertise, and leadership in food allergy and is prepared to immediately address the overarching program goals of CoFAR. The ArCOFAR site is ideally-positioned to function as a CoFAR CRU through contribution of our extensive research experience and by capitalizing on our population's unique geographic and patient demographic characteristics. Our efforts will be directed by the central hypothesis that ArCOFAR will enable the participation of diverse groups of food allergic individuals in expertly designed, innovative clinical trials of the highest quality and scientific value. Our overarching goal is to provide a unique research platform to measurably improve the lives of children and adults with food allergy. This goal will be accomplished by the design and implementation of innovative clinical studies and therapeutic trials via high-quality, high-impact research collaboration. Our hypothesis will be tested by executing four specific aims: 1) Leverage established expertise in food allergy research as a platform to expand clinical trials development in immunotherapeutics through integrated research efforts with other CoFAR CRUs; 2) Apply institutional and community resources to expand ArCOFAR CRU capacity for population-based research in food allergy, including participation in birth cohort and longitudinal outcome studies; 3) Link current inter- and intra-institutional resources to broaden the scope of clinical research participation to include a more diverse population of food allergic patients; 4) Promote career development of new and early career food allergy researchers through active recruiting and mentoring of new faculty and linking established programmatic and network resources. In addition, our cutting-edge clinical trial of walnut oral immunotherapy will address an unmet need in management of tree nut allergy. Further, ArCOFAR's multi-disciplinary team with established expertise and international leadership in food allergy clinical trials, will expand clinical research through the development and testing of novel immunotherapeutics and implementation of cohort studies, while providing mentoring and career development opportunities to early and new career investigators. The outcome of this proposal will be to improve the health of children and adults with food allergy in Arkansas and beyond while advancing the mission of CoFAR to fundamentally change the field of food allergy.