Health Disparities in Alzheimers and Related Diseases

佛罗里达国际大学（FIU）和埃默里大学的申请要求支持四年 研究会议系列，以解决与减少阿尔茨海默病相关的关键科学问题 和相关痴呆症（ADRD）在美国少数民族中的不平等。会议系列 我们建议依靠跨学科研究，使用人口疾病框架，特别关注 神经退行性疾病途径中的种族和性别差异。遗传学和家庭/个人 健康史是不可改变的因素，可改变的因素包括广泛的寿命环境 暴露和生活方式因素。该系列会议的重点是增加对基因如何遗传的理解， 这些因素与环境暴露、家庭和个人健康史以及生活方式密切相关。 产生相互作用的因素，增强或减轻种族内和种族间ADRD的风险， 特别是在非洲裔美国人，拉丁裔和非拉丁裔白人中。这些关键问题在很大程度上 被忽视，是增加使用精准医学进行疾病修饰的知识的基础， 用于在代表性不足的AD人群中开发药物和非药物干预 临床试验该系列的4个相关具体目标是：1。为了了解现有证据如何检验 特定的基因，单独或组合，是不同的种族和性别分布， 与高风险种族群体之间的高风险或对LOAD的保护相关。2.到 描述遗传风险如何受到表观遗传学、年龄、性别、环境暴露等因素的调节， 生活方式/饮食，家庭和个人健康史，种族间和种族内的社会和人口统计学因素 妇女和妇女面临不成比例的LOAD风险。3.为了检查目前关于合并症 如血管疾病、糖尿病和心理健康，在这些疾病中， 代表性不足的人群。4.探索潜在的理论，新的发现和创新的观察， 用于应答者或患者评估的仪器开发和校准，以及测量/分析 提高我们对影响ADRD风险的基因x环境相互作用以及如何影响ADRD风险的理解的策略 方法可以被修改或调整，以用于具有较高风险少数群体的特定研究应用。 人口和妇女。

This application from Florida International University (FIU) and Emory University requests support for a four-year research conference series to address critical scientific issues associated with reducing Alzheimer's Disease and Related Dementia (ADRD) inequities among ethnic minorities in the United States. The conference series we propose rests on interdisciplinary research using a population disease framework, with specific attention to ethnic groups and sex differences in pathways to neurodegenerative diseases. Genetics and family/personal health histories are non-modifiable factors, and modifiable factors include a wide range of lifespan environmental exposures and lifestyle factors. The conference series focuses on increasing understanding about how genetic factors are operating in concert with environmental exposures, family and personal health histories, and lifestyle factors to produce interactions that enhance or mitigate risk of ADRD within and between ethnic groups, specifically among African Americans, Latinos, and non-Latino Whites. These critical issues remain largely overlooked and are fundamental for increasing knowledge for disease modification using precision medicine and for pharmacologic and non-pharmacologic intervention development in under-represented populations in AD clinical trials. The 4 related specific aims of the series are: 1. To understand how the current evidence examines specific genes, individually or in combination, are differentially distributed by ethnicity and sex, and are associated with higher risk or protection against LOAD between and among higher risk ethnic groups. 2. To describe how genetic risk may be modulated by factors such as epigenetics, age, sex, environmental exposures, lifestyle/diet, family and personal health histories, social, and demographic factors between and within ethnic groups and women at disproportionate risk for LOAD. 3. To examine current knowledge about how comorbidities such as vascular diseases, diabetes, and mental health moderate or mediate the increase risk of ADRD in these under-represented populations. 4. To explore underlying theory, new findings, and innovative observation, instrument development and calibration for respondent or patient assessment, and measurement/analytic strategies to improve our understanding of the gene x environment interactions influencing ADRD risk and how methods may be modified or adapted for use in specific research applications with higher risk minority populations and women.