Training in Immunological Mechanisms
Training in Immunological Mechanisms
批准号:
10458735
负责人:
Michael Croft
金额:
$33.27万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
未结题
起止时间:
2016-08-01 至 2026-07-31
关键词:
中文摘要
摘要
该计划将培训博士后研究人员与发育相关的免疫机制。
治疗自身免疫性、炎症性和感染性疾病以及癌症。La Jolla的项目
免疫学研究所(LJI)将有来自LJI的20名教职员工参加,他们的专长是免疫细胞
与糖尿病、炎症性肠病、多发性硬化症、哮喘、
动脉粥样硬化、特应性皮炎、登革热、艾滋病毒、巨细胞病毒、结核病、埃博拉和免疫肿瘤学。
每一位教师导师在免疫学或免疫疾病领域都是国际公认的导师,每一位
有丰富的同行评议的研究经验和记录。该项目将向博士、医学博士、
以及对免疫系统的基础和应用研究感兴趣的医学和博士科学家。培训计划
将包括12-24个月的长凳研究实验室经验,在一名
导师或多名导师,致力于解决与免疫疗法相关的问题。该项目的研究背景
教师导师多种多样,但有共同的主题,以人的初级细胞的生物学为中心
免疫系统,包括T细胞、B细胞、NKT细胞、巨噬细胞、树突状细胞、中性粒细胞等。
然后,培训计划将代表一种跨学科的方法,每个受训人员都将接触到切割
前沿和最先进的免疫学技术和系统,用于使基础和翻译
免疫系统的发现。我们现在和过去的学员都有很好的研究记录。
成就。将在全国范围内招收新学员,努力招收和留住
少数族裔、女性和弱势候选人。实习生将根据他们以前的经历来选择
学术表现、研究经验、出版物、面试和主管的建议。
学员将参加机构研讨会、期刊俱乐部、课程和免疫学会议。
旨在扩大他们对免疫学和免疫性疾病的理解广度。所有受训人员
将遵循负责任的研究行为和科学诚信的原则。世界银行的目标是
该计划旨在促进全面发展的免疫学家的发展,他们能够填补急需的学术
职位,谁能竞争并成功地获得独立研究资助,谁能
促进旨在治疗免疫相关疾病的生物技术和制药方法。
英文摘要
Abstract
This program will train postdoctoral research scientists in immunological mechanisms related to development
and treatment of Autoimmune, Inflammatory, and Infectious Disease, and Cancer. The program at La Jolla
Institute for Immunology (LJI) will involve 20 faculty members from LJI whose expertise is in immune cell
function that relates to diseases such as diabetes, inflammatory bowel disease, multiple sclerosis, asthma,
atherosclerosis, atopic dermatitis, dengue, HIV, cytomegalovirus, tuberculosis, ebola, and immuno-oncology.
Each faculty mentor is internationally recognized in the field of immunology or immunological disease and each
has substantial peer-reviewed research experience and track records. The program will be open to PhD, MD,
and MD/PhD scientists interested in basic and applied research of the immune system. The training program
will consist of a bench research laboratory experience of 12-24 months, under the close supervision of a
mentor or several mentors working on problems relevant to immunotherapy. The research backgrounds of the
faculty mentors are diverse, but with common themes centered on the biology of the primary cells of the
immune system, including T cells, B cells, NKT cells, macrophages, dendritic cells, neutrophils, and others.
The training program will then represent an interdisciplinary approach where each trainee is exposed to cutting
edge and state-of-the-art immunological techniques and systems for making fundamental and translational
discoveries of the immune system. Our current and past trainees have excellent records of research
accomplishments. New trainees will be recruited nationwide and efforts will be made to recruit and retain
exceptional minority, women, and disadvantaged candidates. Trainees will be chosen on the basis of their prior
academic performance, research experience, publications, interviews, and recommendations from supervisors.
Trainees will participate in institutional seminars, journal clubs, courses, and immunology conferences
designed to expand the breadth of their understanding of immunology and immunological disease. All trainees
will be instructed in the principles of responsible conduct of research and scientific integrity. The goals of the
program are to foster the development of well-rounded immunologists who can fill much needed academic
positions, who can compete and be successful in obtaining independent research grants, and who can
contribute to biotechnology and pharmaceutical approaches, aimed at treatment of immune-related diseases.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
TWEAK and Skin Inflammation
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批准号:10400699
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项目类别:
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资助金额:$39.2万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy
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批准号:10531229
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项目类别:
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资助金额:$51.26万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
Immune Regulation by Deubiquitination
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批准号:9982199
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项目类别:
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资助金额:$45.0万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy
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批准号:10053328
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项目类别:
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资助金额:$52.31万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
TWEAK and Skin Inflammation
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批准号:9910059
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项目类别:
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资助金额:$39.6万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
A Treg cell-intrinsic CTLA4-PKC-eta signaling pathway mediating contact-dependent suppression of tumor immunity: A novel target for cancer immunotherapy
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批准号:10310411
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项目类别:
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资助金额:$51.26万
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财政年份:2018
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负责人:Michael Croft
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依托单位:
TWEAK and Skin Inflammation
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批准号:10152528
-
项目类别:
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资助金额:$38.41万
-
财政年份:2018
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负责人:Michael Croft
-
依托单位:
Immune Regulation by Deubiquitination
-
批准号:9788250
-
项目类别:
-
资助金额:$45.0万
-
财政年份:2018
-
负责人:Michael Croft
-
依托单位:
Training in Immunological Mechanisms
-
批准号:9321444
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项目类别:
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资助金额:$33.47万
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财政年份:2016
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负责人:Michael Croft
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依托单位:
Training in Immunological Mechanisms
-
批准号:10675443
-
项目类别:
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资助金额:$25.73万
-
财政年份:2016
-
负责人:Michael Croft
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依托单位:
Training in Immunological Mechanisms
-
批准号:10269804
-
项目类别:
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资助金额:$37.53万
-
财政年份:2016
-
负责人:Michael Croft
-
依托单位:
Novel PTPRD interaction Controlling T cell Responsiveness
-
批准号:9077779
-
项目类别:
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资助金额:$26.55万
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财政年份:2016
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负责人:Michael Croft
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依托单位:
Structural Characterization of 4-1BB-Galectin-9 Complexes
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批准号:8679808
-
项目类别:
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资助金额:$8.85万
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财政年份:2014
-
负责人:Michael Croft
-
依托单位:
Control of Airway Tolerance
-
批准号:8577804
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项目类别:
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资助金额:$41.6万
-
财政年份:2013
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负责人:Michael Croft
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依托单位:
Control of Airway Tolerance
-
批准号:8661698
-
项目类别:
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资助金额:$44.25万
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财政年份:2013
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负责人:Michael Croft
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依托单位:
Control of Airway Tolerance
-
批准号:9267076
-
项目类别:
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资助金额:$44.25万
-
财政年份:2013
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负责人:Michael Croft
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依托单位:
Novel costimulatory pathways required for T cell regulation
-
批准号:8495230
-
项目类别:
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资助金额:$43.81万
-
财政年份:2013
-
负责人:Michael Croft
-
依托单位:
Control of Airway Tolerance
-
批准号:9054041
-
项目类别:
-
资助金额:$44.25万
-
财政年份:2013
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负责人:Michael Croft
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依托单位:
Control of Airway Tolerance
-
批准号:8839196
-
项目类别:
-
资助金额:$44.25万
-
财政年份:2013
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负责人:Michael Croft
-
依托单位:
Novel costimulatory pathways required for T cell regulation
-
批准号:8377924
-
项目类别:
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资助金额:$46.61万
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财政年份:2012
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负责人:Michael Croft
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依托单位:
海外基金