Functions of the Cortical Amygdala in social behavior

项目摘要 攻击性是一种进化保守的行为，它控制着社会等级，保护有价值的 像配偶、食物和领土这样的资源。在大多数情况下，攻击性是必要的、适应性的组成部分 社交行为。然而，在人类中，当某些形式的攻击性被认为是病态的 威胁生命，增加受害者精神损害的风险，并给社会造成经济负担。 大量证据表明，攻击性与人类面部知觉的异常有关。 身体上具有攻击性的人倾向于将模棱两可的面孔识别为威胁或愤怒。这 表明这些人有一种知觉偏差，这种偏见削弱了个人解释 正确的威胁级别。在人类和非人类灵长类动物中，有充分的证据表明杏仁核扮演着 在社会认知中的关键作用。对人类和非人类灵长类的研究考察了杏仁核在 社会知觉主要集中在杏仁外侧核和基底外侧核，因为它们与 视觉系统，因为它们高度依赖视觉。相反，啮齿动物更依赖于 因此，我们需要更深入地了解杏仁核与嗅觉结构之间的相互作用。 社交聚会。杏仁皮质后核(COAP)就是这样一个区域，它接受来自 嗅觉结构。我们的初步数据表明，COAP中ESR-1细胞的激活是必要的 攻击性行为发生在男性身上而不是女性身上。此外，这些细胞表现出活性的增加。 在雄性动物的攻击行为中。除了主要嗅球的预期输入外，我们还发现 这个细胞群也接受腹侧纹状体苍白球系统的输入，该系统参与 激励过程。对于这个提议的K99阶段，我将测试腹侧 纹状核系统通过调节COAP中的准备活动来影响攻击动机。超过了 R00阶段，我将建立一个研究计划来测试COAP介导状态依赖的假设 对社会嗅觉刺激的反应。为了在老鼠身上诱导一种“攻击性状态”，我们将使用 教唆模式。这项提议的结果将增加该领域对非感官 变量会影响传统上被称为感觉区的区域。此外，拟议中的培训将使我 制定一项未来的研究计划，旨在确定改变的影响的潜在机制 感知过程中的行为状态。

Project Summary Aggression is an evolutionarily conserved behavior that controls social hierarchies and protects valuable resources like mates, food, and territory. In most cases, aggression is a necessary, adaptive component of social behavior. In humans, however, some forms of aggression are considered pathological when they threaten lives, increase the risk of psychiatric impairment in victims, and incur economic burdens on society. Considerable evidence indicates that aggression is associated with aberrant facial perception in humans. Physically aggressive individuals have a tendency to identify ambiguous faces as threatening or angry. This suggests that these individuals have a perceptual bias which impairs the ability of the individual to interpret the level of threat correctly. There is ample evidence in human and non-human primates that the amygdala plays a key role in social perception. Studies with human and non-human primates examining the amygdala's role in social perception have focused on the lateral and basolateral amygdala given their extensive connections with the visual system and because they are a highly dependent on vision. Conversely, rodents are more reliant on olfaction, and thus, we need a deeper understanding of amygdala interactions with olfactory structures during social encounters. The posterior cortical amygdala (COAp) is one such region which receives input from olfactory structures. Our preliminary data suggest that activation of ESR-1 cells in the COAp are necessary for aggressive behavior to occur in males but not females. Furthermore, these cells show an increase in activity during attack behavior in males. In addition to the expected input from the main olfactory bulb, we discovered that this cell population also receives input from the ventral striatopallidal system, which is involved in motivational processes. For the K99 phase of this proposal, I will test the hypothesis that the ventral striatopallidal system affects the motivation to attack by modulating preparatory activity in the COAp. Over the R00 phase, I will build a research program to test the hypothesis that the COAp mediates state-dependent responses to social olfactory stimuli. In order to induce an “aggressive state” in mice we will use the social instigation model. The results from this proposal will increase the field's understanding of how non-sensory variables affect what are traditionally known as sensory regions. In addition, the proposed training will allow me to develop a future research program geared towards identifying mechanisms underlying the effects of altered behavioral states on perceptual processes.