Technology and Data Science Core

项目摘要/摘要 改进发声功能亢进预防、诊断和治疗的临床研究中心 (VHCRC)汇集了一支经验丰富且富有成效的多学科调查团队，以追求 全面的研究计划侧重于对功能性发声障碍的研究。技术 数据科学核心(Tech Core)是VHCRC的关键组件，提供中央服务和 相关资源包括技术和设备的采购、设置和维护 马萨诸塞州总医院语音中心(MGH语音中心)和波士顿医疗中心；数据质量 检查和前处理；所有项目的信号/图像处理资源和服务；集中 整合来自所有项目的数据类型的数据库管理；向所有项目提供统计和机器学习服务 项目；与项目合作者和更广泛的研究社区共享数据。 Tech Core主要位于MGH语音中心，并包括一个最先进的语音诊所， 嗓音功能测试的声音和语音实验室，以及喉部外科研究实验室 技术开发和持续的设备维护。技术核心将提供生物统计咨询 通过授予麻省理工学院卫生专业研究所的分奖，向VHCRC调查人员提供专业知识，特别是 关于纵向数据的分析、潜在轮廓分析(用于分型的非监督聚类)、 结构方程模型和分层线性模型。技术核心奖还向麻省理工学院颁发了一个子奖 计算机科学和人工智能实验室将提供先进的机器学习服务 (监督分类、非监督聚类和深度学习)给VHCRC调查人员。VHCRC 将大于其各部分之和，因为技术核心将通过集中管理来提高项目效率 劳动密集型数据库组织任务，检索和组织有关标准临床语音的数据 为登记的患者提供评估和治疗服务，执行高级语音分析，并管理 通过对数千小时的门诊数据进行自动和半自动的前处理来提高数据质量 参与者数据。 技术核心将有效地将所有项目获得的数据类型集成到一个集中的、多维的 语音数据库将被组织、编目，并可供VHCRC调查人员和更广泛的人员使用 研究社区。技术核心将及时协调高质量数据的共享，并在 与行政核心一起，促进所有研究团队之间的定期沟通，以促进 正在进行的研究进展。

Project Summary/Abstract The Clinical Research Center for the Improved Prevention, Diagnosis, and Treatment of Vocal Hyperfunction (VHCRC) brings together a multidisciplinary team of experienced and productive investigators to pursue a comprehensive program of research focused on the study of hyperfunctional voice disorders. The Technology and Data Science Core (Tech Core) is a critical component of the VHCRC and provides central services and resources related to include procurement, setup, and maintenance of technology and equipment at the Massachusetts General Hospital Voice Center (MGH Voice Center) and Boston Medical Center; data quality checks and pre-processing; signal/image processing resources and services for all Projects; centralized database management integrating data types from all Projects; statistical and machine learning services to all Projects; and data sharing with Project collaborators and the broader research community. The Tech Core is primarily housed at the MGH Voice Center and includes a state-of-the-art voice clinic, the Voice and Speech Laboratory for vocal function testing, and the Laryngeal Surgery Research Laboratories for technology development and ongoing device maintenance. The Tech Core will provide biostatistical consulting expertise to VHCRC investigators through a subaward to the MGH Institute of Health Professions, especially with respect to the analysis of longitudinal data, latent profile analysis (unsupervised clustering for subtyping), structural equation modeling, and hierarchical linear modeling. The Tech Core also has a subaward to the MIT Computer Science and Artificial Intelligence Laboratory to provide advanced machine learning services (supervised classification, unsupervised clustering, and deep learning) to VHCRC investigators. The VHCRC will be greater than the sum of its parts because the Tech Core will increase project effectiveness by centralizing labor-intensive database organizational tasks, retrieving and organizing data regarding standard clinical voice assessment and treatment services for enrolled patients, performing advanced voice analysis, and managing data quality through automatic and semi-automatic pre-processing of thousands of hours of ambulatory participant data. The Tech Core will effectively integrate data types obtained by all Projects into a centralized, multidimensional voice database that will be organized, catalogued, and available to VHCRC investigators and the broader research community. The Tech Core will coordinate the sharing of high-quality data in a timely manner and, in conjunction with the Administrative Core, facilitate regular communication among all research teams to stimulate ongoing research progress.