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中文摘要
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附件核心(核心B) 项目摘要 发展核心是DC CFAR使命的驱动力,以加强我们的多机构努力, 促进和支持有助于在华盛顿及其他地区结束艾滋病毒流行的研究, 与政府和社区的伙伴关系。核心由经验丰富的高级团队领导, 自2010年CFAR成立以来的艾滋病毒研究人员:Michael Bukrinsky博士(GW,主任),Sylvia银 (GW,联合主任)和安东尼武托(胡,联合主任)。核心的具体目标是:1)促进 并支持与艾滋病流行有关的创新、协作和多学科艾滋病毒研究, 华盛顿特区通过试点奖,过渡调查和小额赠款计划; 2)领导一个 针对早期和过渡期艾滋病毒调查人员的动态辅导计划,重点是妇女 和代表性不足的少数群体;以及3)提供教育和网络活动, 在艾滋病毒研究方面开展多学科和跨机构合作。 自2010年以来,发展核心已经审查了165个试点奖申请,并资助了63个280万美元。试点 从2010年到2016年,130万美元的奖励导致NIH新拨款1120万美元,占761%。 投资回报率在所有DC CFAR试点奖获得者中,五十六%是女性,23%是女性。 被低估的少数民族。自2018年以来,核心审查了8份来自非艾滋病毒R 01的申请, 资助了过渡调查人员,资助了两名20万美元的调查人员,并在2010年以来提供了36笔6.8万美元的小额赠款。 2010.核心的指导,教育和培训计划补充了奖励计划,提供 为华盛顿特区的艾滋病毒研究人员提供全面支持,包括个性化的核心服务, 研讨会,指导研讨会,具体目标审查,期刊俱乐部网络研讨会,网络机会和 全市范围的研究研讨会。
英文摘要
DEVELOPMENTAL CORE (CORE B) PROJECT SUMMARY The Developmental Core is the driving force of the DC CFAR mission to intensify our multi-institutional effort to promote and support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. The Core has been led by a highly experienced team of senior HIV researchers since the inception of the CFAR in 2010: Drs. Michael Bukrinsky (GW, Director), Sylvia Silver (GW, Co-Director) and Anthony Wutoh (HU, Co-Director). The Specific Aims of the Core are: 1) to promote and support innovative, collaborative and multidisciplinary HIV research that is pertinent to the epidemic in Washington, DC through the Pilot Awards, Transitioning Investigator and microgrants programs; 2) to lead a dynamic mentoring program for early stage and transitioning HIV investigators with an emphasis on women and underrepresented minorities; and 3) to provide educational and networking activities that promote multidisciplinary and cross-institutional collaboration in HIV research. Since 2010, the Developmental Core has reviewed 165 pilot award applications and funded 63 for $2.8M. Pilot awards granted from 2010-2016 for $1.3M have resulted in $11.2M in new NIH grants representing a 761% return on investment. Fifty-six percent of all DC CFAR pilot award recipients have been women and 23% have been underrepresented minorities. Since 2018, the Core has reviewed eight applications from non-HIV R01- funded transitioning investigators, funding two for $200,000, and has awarded 36 microgrants for $68K since 2010. The Core's mentoring, educational and training programs complement the awards program by providing comprehensive support to DC-based HIV researchers including individualized Core services, grantwriting workshops, mentoring workshops, specific aims reviews, journal club webinars, networking opportunities and citywide research seminars.
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Development of NLRP3 inhibitors for HIV-associated neuroinflammation
  • 批准号:
    10548568
  • 项目类别:
  • 资助金额:
    $21.2万
  • 财政年份:
    2022
  • 负责人:
    MICHAEL Ilya BUKRINSKY
  • 依托单位:
Trained immunity induced by Nef-containing extracellular vesicles
  • 批准号:
    10664031
  • 项目类别:
  • 资助金额:
    $20.19万
  • 财政年份:
    2022
  • 负责人:
    MICHAEL Ilya BUKRINSKY
  • 依托单位:
Trained immunity induced by Nef-containing extracellular vesicles
  • 批准号:
    10534002
  • 项目类别:
  • 资助金额:
    $24.23万
  • 财政年份:
    2022
  • 负责人:
    MICHAEL Ilya BUKRINSKY
  • 依托单位:
Development of NLRP3 inhibitors for HIV-associated neuroinflammation
  • 批准号:
    10650871
  • 项目类别:
  • 资助金额:
    $23.61万
  • 财政年份:
    2022
  • 负责人:
    MICHAEL Ilya BUKRINSKY
  • 依托单位: