Supplement to R01 NS124477

摘要 我们请求对我们的NINDS资助的R01 NS124477的新奇致病药物进行行政补充 HIV相关中枢神经系统疾病的机制为一名乌克兰人提供博士后职位 科学家达里亚·斯塔罗塞拉博士。她将在父母资助的项目中接管一个新的研究方向 Grant，研究训练性免疫在神经炎发病机制中所起的作用 手。我们最近的发现表明，神经炎可能在脑髓细胞和 神经胶质细胞暴露于携带HIV-1蛋白Nef的胞外小泡。到目前为止，我们已经演示了这一点 对外周血和骨髓髓系细胞的影响，以及对脑细胞的进军将是一种新颖的 在神经生物学方面的发展，并对父母赠款的所有具体目标做出重大贡献。鉴于Dr。 Starosyla在免疫学、病毒学和抗病毒治疗开发方面的经验，我们相信她很好 适合接手该项目这一部分的主要工作。除了这一请求背后的科学原因外， 除了补充资金，它还具有人道主义和政治意义。正在进行的乌克兰战争 严重影响全国所有科技企业，不仅危及现在，也危及未来 乌克兰的科学进步。在这场悲剧中，向乌克兰科学家提供支持和培训至关重要 因此，当战争结束时，他们可以返回乌克兰，准备重建 科学计划。为Starosyla博士提供的培训将为她未来的研究生涯做准备 神经生物学和病毒学的重叠。

Abstract We request an Administrative Supplement to our NINDS-funded grant R01 NS124477 ‘Novel pathogenic mechanism of HIV-associated CNS neurological disorders’ to fund a postdoctoral position for a Ukrainian scientist, Dr. Daria Starosyla. She will take over a new research direction in the project funded by the parent grant, investigation of the role that trained immunity plays in the neuroinflammation underlying pathogenesis of HAND. Our recent discoveries suggested a possibility that neuroinflammation is ‘imprinted’ in brain myeloid and glial cells by exposure to extracellular vesicles carrying HIV-1 protein Nef. So far, we have demonstrated this effect in peripheral blood and bone marrow myeloid cells, and the foray into the brain cells will be a novel development in neurobiology and contribute significantly to all Specific Aims of the parent grant. Given Dr. Starosyla’s experience in immunology, virology and development of anti-viral treatments, we believe she is well fit to take over the leading role on this part of the project. In addition to scientific reasons behind this request for Supplemental Funding, it also carries a humanitarian and political significance. The ongoing war in Ukraine severely affects all scientific enterprises in the country and endangers not only the present, but also the future scientific progress in Ukraine. It is critical to provide support and training to Ukrainian scientists during this tragic period in the history of their country, so that when the war ends, they can return to Ukraine ready to rebuild scientific programs. The training provided to Dr. Starosyla will prepare her for a future research career in the overlap of neurobiology and virology.