Supplement to R01 NS124477

R01 NS124477 的补充

• 批准号: 10719354
• 负责人: MICHAEL Ilya BUKRINSKY
• 金额: $ 3.42万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10719354
• 关键词: Administrative Supplement; Affect; Bone Marrow; Brain; Cells; Country; Development; Distress; Exposure to; Funding; Future; Grant; HIV; HIV-1; Hand; Immune; Immunity; Immunology; Investigation; Myeloid Cells; National Institute of Neurological Disorders and Stroke; Neurobiology; Neuroglia; Pathogenesis; Pathogenicity; Play; Politics; Positioning Attribute; Postdoctoral Fellow; Recording of previous events; Research; Role; Scientist; Time; Training; Ukraine; War; antiviral drug development; brain cell; career; experience; extracellular vesicles; imprint; nef Protein; nervous system disorder; neuroinflammation; novel; parent grant; peripheral blood; programs; virology

Abstract We request an Administrative Supplement to our NINDS-funded grant R01 NS124477 ‘Novel pathogenic mechanism of HIV-associated CNS neurological disorders’ to fund a postdoctoral position for a Ukrainian scientist, Dr. Daria Starosyla. She will take over a new research direction in the project funded by the parent grant, investigation of the role that trained immunity plays in the neuroinflammation underlying pathogenesis of HAND. Our recent discoveries suggested a possibility that neuroinflammation is ‘imprinted’ in brain myeloid and glial cells by exposure to extracellular vesicles carrying HIV-1 protein Nef. So far, we have demonstrated this effect in peripheral blood and bone marrow myeloid cells, and the foray into the brain cells will be a novel development in neurobiology and contribute significantly to all Specific Aims of the parent grant. Given Dr. Starosyla’s experience in immunology, virology and development of anti-viral treatments, we believe she is well fit to take over the leading role on this part of the project. In addition to scientific reasons behind this request for Supplemental Funding, it also carries a humanitarian and political significance. The ongoing war in Ukraine severely affects all scientific enterprises in the country and endangers not only the present, but also the future scientific progress in Ukraine. It is critical to provide support and training to Ukrainian scientists during this tragic period in the history of their country, so that when the war ends, they can return to Ukraine ready to rebuild scientific programs. The training provided to Dr. Starosyla will prepare her for a future research career in the overlap of neurobiology and virology.

摘要 我们要求对我们的NINDS资助的赠款R 01 NS 124477“新型致病性 艾滋病毒相关的中枢神经系统疾病的机制'资助乌克兰博士后职位 科学家达里亚·斯塔罗斯拉博士她将在由家长资助的项目中接手一个新的研究方向 格兰特，研究训练的免疫在神经炎症的发病机制中的作用， 手我们最近的发现表明，神经炎症可能是“印记”在脑髓样细胞， 神经胶质细胞暴露于细胞外囊泡携带HIV-1蛋白Nef。到目前为止，我们已经证明了这一点 在外周血和骨髓髓样细胞中的作用，以及对脑细胞的进军将是一个新的 神经生物学的发展，并有助于显着的所有具体目标的父母补助金。鉴于博士。 Starosyla在免疫学、病毒学和抗病毒治疗开发方面的经验，我们相信她很好， 适合接任该项目这一部分的领导角色。除了这一要求背后的科学原因外， 作为补充资金，它还具有人道主义和政治意义。乌克兰正在进行的战争 严重影响了该国的所有科学事业，不仅危及现在，而且危及未来。 乌克兰的科学进步。在这场悲剧中，向乌克兰科学家提供支持和培训至关重要。 这样，当战争结束时，他们就可以回到乌克兰，准备重建。 科学计划。为Starosyla博士提供的培训将使她为未来的研究事业做好准备。 神经生物学和病毒学的交叉