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Bioengineering core

Bioengineering core
生物工程核心
批准号：
10642594
负责人：
Zahi A. Fayad
金额：
$32.05万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
项目状态：
未结题
起止时间：
2023-06-01 至 2028-03-31
来源：
https://reporter.nih.gov/project-details/10642594
关键词：
BiologyBiomedical EngineeringBone MarrowCD8-Positive T-LymphocytesCD8B1 geneCellsChemistryDepositionDevelopmentDoseDrug KineticsEnsureEpigenetic ProcessGlycolysisGoalsHuman ResourcesITGAM geneImageImmuneImmunityImmunoPETImmunotherapeutic agentInterventionLibrariesLiverMass Spectrum AnalysisMetabolicMetabolismModelingMonitorMusMyeloid CellsPositron-Emission TomographyProcessRadioactiveRadiochemistryRadioisotopesRegimenResearchSamplingSpleenTherapeuticTherapeutic StudiesTissuesTrainingTransplantationbiomedical imagingexperienceexperimental studyfluorodeoxyglucosefluorophoreimaging agentimaging probeimaging studyin vivonanobiologicnanobodiesnanolabelnanomaterialsnanomedicinenanotherapeuticnanotherapynovelnuclear imagingpharmacodynamic modelpharmacokinetics and pharmacodynamicsprogramssuccesstherapeutic target

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中文摘要
翻译
总结-核心B 核心B，即生物工程核心，将由Zahi Fayad博士指导，并为所有五个项目提供服务 多年的方案。核心方案的目标包括： 1)通过开发和提供训练有素的免疫抑制剂，简化所有治疗实验 纳米生物学 2)通过提供免疫PET探针促进核成像项目。 3)确保放射性材料的安全使用和处置。 已经开发的纳米生物制剂和PET探针将对该计划项目的成功非常宝贵。 此外，核心B强大的化学经验将促进其他纳米疗法的开发， 在整个项目中所需的成像探头。
英文摘要
SUMMARY – CORE B Core B, the Bioengineering Core, will be directed by Dr. Zahi Fayad and serve all three Projects over all five years of the Program. The goals of the Core include: 1) Streamlining all therapeutic experiments by developing and providing trained immunity-inhibiting nanobiologics. 2) Facilitating the nuclear imaging projects by providing immuno-PET probes. 3) Ensuring the safe use and disposal of radioactive materials. The already developed nanobiologics and PET probes will be invaluable for the success of this Program Project. In addition, Core B’s strong chemistry experience will facilitate the development of additional nanotherapies and imaging probes as desired throughout this Project.
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