Measuring Electrical Activity from the Human Brain to Predict Memory Formation and Behavior Across the Lifespan

项目总结(未更改原始的父R00提交) 记忆是人类认知的核心，经历了长期的发育成熟和年龄- 相关的下降，并在许多神经和神经精神障碍中中断。 尽管记忆在健康和疾病中起着核心作用，但令人惊讶的是，人们对记忆 支持人类一生记忆的神经机制。这个R00项目将 结合神经外科患者罕见的颅内记录和先进的 实时跟踪记忆形成和维护的电生理数据分析 时间，并预测儿童、青少年和成年人的行为。随着这些时空的变化 记忆形成和维持的精确措施，这项研究将解决关键差距 关于这一核心神经认知功能的知识。颅脑损伤的对比分析 记录和头皮脑电(EEG)测量将进一步识别非侵入性 适用于发育、寿命和疾病相关研究的脑电指标。作为终身教职- 追踪西北大学范伯格医学院的独立研究员，PI将 继续并扩大在K99阶段取得的进展，包括两个相辅相成的 创新方向。目标1将映射记忆形成和维持的预测因素 同时记录单个神经元的水平到大规模神经回路的水平 取自成人的内侧颞叶和前额叶区域。目标2将定义 使用颅内技术预测终身记忆成功的电生理学指标 儿童、青少年和青少年的内侧颞叶和前额叶区域的录音 成年人。最重要的假设是，在内侧颞叶， 前额叶和内侧颞叶-前额叶回路将预测个体的记忆 队形。这些目标的实现将产生对人类的新的机械论解释 从童年到成年的记忆形成。这项研究与优先事项6直接相关 以及《大脑2025》报告中的第七条。此R00过渡方案中的新功能是额外的集合 来自儿科患者的单单位神经元数据，为PI提交 在资助期结束前独立申请R01。这项由R00资助的工作将建立 首批在国内或国际上存在的单一单位儿科研究项目之一。

PROJECT SUMMARY (not changed from the original parent R00 submission) Memory is core to human cognition, undergoes protracted developmental maturation and age- related decline, and is disrupted in numerous neurological and neuropsychiatric disorders. Despite the central role of memory in health and disease, remarkably little is known about the neural mechanisms supporting memory across the human lifespan. This R00 project will combine rare intracranial recordings from neurosurgical patients and advanced electrophysiological data analysis to track memory formation and maintenance in real time, and predict behavior in children, adolescents, and adults. With these spatiotemporally precise measures of memory formation and maintenance, this research will address critical gaps in knowledge about this core neurocognitive function. Comparative analysis between intracranial recordings and scalp electroencephalography (EEG) measures will further identify noninvasive EEG metrics applicable to developmental, lifespan, and disease-related research.As a tenure- track independent investigator at Northwestern University Feinberg School of Medicine, the PI will continue and expand on the progress made during the K99 phase in two complementary, innovative directions. Aim 1 will map predictors of memory formation and maintenance from the level of single neurons to that of large-scale neural circuits using simultaneous recordings obtained from medial temporal and prefrontal regions in adults. Aim 2 will define electrophysiological predictors of memory success across the lifespan using intracranial recordings obtained from medial temporal and prefrontal regions in children, adolescents, and adults. The overarching hypothesis is that sub-second interactions in medial temporal, prefrontal, and medial temporal-prefrontal circuits will predict individual memory formation. Completion of these Aims will generate novel mechanistic explanations of human memory formation from childhood into adulthood. This research is directly relevant to Priorities #6 and #7 of the BRAIN 2025 Report. New in this R00 transition proposal is the additional collection of single-unit neuronal data from pediatric patients in preparation for the PI to submit an independent R01 application by the end of the funding period. This R00-funded work will establish one of the first single-unit pediatric research programs to exist nationally or internationally.