Administrative Core

耶鲁大学/NIDA神经蛋白质组学中心的主题是“成瘾信号改变的蛋白质组学”， 暴露于滥用药物会篡夺细胞内信号传导过程的调节 在大脑奖励中心，反过来改变基因表达，蛋白质翻译，和翻译后 蛋白质的修饰。重复暴露于药物滥用导致这些信号的稳定改变 这些系统对大脑化学变化和成瘾者结构的发展至关重要 个脑袋该中心的主要目标是汇集耶鲁大学和其他8个非常强大的项目， 非耶鲁大学机构在蛋白质组学，信号转导和药物成瘾研究，以创造一个协同， 一个虚拟环境，它可以独特地利用现有资源和我们的能力， 资源（例如，通过NIH SIGs提供仪器资金），以表征神经元信号传导过程， 识别在暴露于滥用药物时发生的蛋白质信号传导的适应性变化。 行政核心将在联合国的组织和运作中发挥重要作用。 神经蛋白质组学中心。其任务之一将是为中心的研究基地招募最优秀的人才 确保核心有足够的空间，最好的仪器和工作人员， ITS和基础设施支持，并响应并不断开发创新的解决方案， 以最佳方式满足中心研究人员和试点项目受资助者的生物技术需求;促进 研究人员和科学核心之间的互动;并确保中心保持其重点， 主题，并积极参与培训和教育。 行政核心的具体目标是：1.管理耶鲁/NIDA神经蛋白质组学 中心; 2.管理、支持和协调研究支持核心的活动并优化其 中心研究者使用; 3.优化神经蛋白质组学中心的整体运作及其相互作用 与其他中心和组织;和4.监督神经蛋白质组学中心的培训使命。 通过其跨学科和协作组织，行政核心将带来高度的 合格的信号转导和药物成瘾研究人员进入中心，使蛋白质组学专家可以 利用其迅速发展的工具，了解药物滥用的作用机制。他们 将得到广泛的仪器和训练有素的工作人员的支持， 该中心最佳地将最强大的蛋白质组学技术应用于蛋白质组学的研究。 药物滥用后发生的变化。

The theme of the Yale/NIDA Neuroproteomics Center, “Proteomics of Altered Signaling in Addiction”, follows from the premise that exposure to drugs of abuse usurps regulation of intracellular signaling processes in brain reward Centers that in turn alters gene expression, protein translation, and post-translational modifications of proteins. Repeated exposure to drugs of abuse results in stable alterations in these signaling systems that are critical for the changes in brain chemistry and development of the structure of the addicted brain. The major goal of the Center is to bring together exceptionally strong programs from Yale and 8 other non-Yale institutions in proteomics, signal transduction, and drug addiction research to create a synergistic, virtual environment that uniquely leverages existing resources and our ability to successfully compete for future resources (e.g., instrumentation funding via NIH SIGs) to characterize neuronal signaling processes and to identify adaptive changes in protein signaling that occur in response to exposure to drugs of abuse. The Administrative Core will play an essential role in the organization and operation of the Neuroproteomics Center. Among its tasks will be to recruit for the Center's research base the very best investigators in the field; ensure the Cores have sufficient space, the best possible instrumentation and staff, ITS and infrastructure support, and are responsive to and are continuously developing innovative solutions to optimally meet the biotechnological needs of the Center's investigators and pilot project grantees; promote interactions among the investigators and scientific cores; and ensure that the Center maintains its focus on its theme and actively engages in training and education. The Specific Aims of the Administrative Core will be to: 1. Administer the Yale/NIDA Neuroproteomics Center; 2. Administer, support, and coordinate the activities of the Research Support Cores and optimize their use by Center investigators; 3. Optimize overall operation of the Neuroproteomics Center and its interactions with other Centers and organizations; and 4. Oversee the training mission of the Neuroproteomics Center. Through its interdisciplinary and collaborative organization, the Administrative Core will bring highly qualified signal transduction and drug addiction researchers into the Center so that proteomic specialists can utilize their rapidly evolving tools to gain understanding of the mechanisms of actions of drugs of abuse. They will be supported by an extensive array of instrumentation and highly trained staff that will allow members of this Center to optimally bring the most powerful proteomic technologies to bear on the study of the proteomic changes that occur in response to drugs of abuse.