Daily Ovarian Hormone Exposure and Loss of Control Eating in Adolescent Girls: A Within-Day RDoC Study

项目总结/摘要 在青春期女孩中，饮食失控是一种与精神疾病相关的适应不良饮食行为。 发病率，包括饮食失调综合症的发展。然而，每天的生物行为 促使腐蚀的因素还不为人所知。卵巢激素水平是关键的生物学因素 与青春期女孩饮食失调的病因相关。然而，关于卵巢激素 暴露预示着青春期女孩的饮食不发达。两个相关的研究领域标准 与进食障碍有关的RDoC包括奖励预期和反应抑制。这些过程 与卵巢激素水平的变化有关，因此，每日激素暴露可能会导致 奖励预期和反应抑制的失调，这反过来又可能导致暴食。给定 关于少女每日激素暴露和暴食的研究存在巨大差距， 瞬时中介机制，本研究的目的是研究的模式和机制， 卵巢激素暴露对青春期女孩月经周期的饮食影响。生态 与每日激素采样配对的瞬时评估（EMA）将用于每日检查， 每日激素暴露和暴食之间的瞬时关联以及 奖励预期和反应抑制的瞬间波动。通常骑自行车的青春期女孩 已达到月经初潮的妇女将提供每日唾液样本进行激素分析，并接受EMA治疗， 移动的手机35天。在EMA期间，女孩将报告暴食，并将完成应对措施 抑制和奖励预期。这项研究有两个具体目标。具体目标1是表征 青春期女孩每日激素暴露与暴食之间的关联，具体目标2是 检查每日激素暴露和瞬时RDoC构建的中介模型（即，响应 抑制和奖励预期）预测暴食。这项工作对发展 在RDoC框架内，在青春期女孩中建立新的真实生物行为模型， 指导未来的理论发展和治疗。例如，结果将提供 针对青春期女孩的新型干预措施的治疗目标的初步证据-例如，的响应 在月经周期的各个阶段可能需要抑制干预， 数据区.

PROJECT SUMMARY/ABSTRACT In adolescent girls, loss of control (LOC) eating is a maladaptive eating behavior associated with psychiatric morbidity, including the development of full syndrome eating disorders. However, the daily biobehavioral factors that precipitate LOC eating are not well known. Ovarian hormone levels are key biological factors associated with the etiology of eating disorders in adolescent girls. Yet, models on how daily ovarian hormone exposure predicts LOC eating in adolescent girls are underdeveloped. Two relevant research domain criteria (RDoC) implicated in eating disorders include reward anticipation and response inhibition. These processes associate with variations in ovarian hormone levels, and thus, daily hormone exposure may cause dysregulation in reward anticipation and response inhibition, which may in turn precipitate LOC eating. Given the substantial gap in research on daily hormone exposure and LOC eating in adolescent girls including momentary mediating mechanisms, the goal of this study is to examine the patterns and mechanisms of ovarian hormone exposure on LOC eating across the menstrual cycle in adolescent girls. Ecological momentary assessment (EMA) paired with daily hormonal sampling will be used to examine daily and momentary associations between daily hormone exposure and LOC eating and the mediating role of momentary fluctuations in reward anticipation and response inhibition. Normally cycling adolescent girls who have reached menarche will provide daily saliva samples for hormone analysis and be administered EMA for 35 days on mobile phones. During EMA, girls will report LOC eating and will complete measures of response inhibition and reward anticipation. This study has two specific aims. Specific Aim 1 is to characterize the association between daily hormone exposure and LOC eating in adolescent girls, and Specific Aim 2 is to examine a mediation model of daily hormone exposure and momentary RDoC constructs (i.e., response inhibition and reward anticipation) in predicting LOC eating. This work has implications for the development of new real-world biobehavioral models of LOC eating in adolescent girls within the RDoC framework, which will guide future theoretical developments and treatment for LOC eating. For example, results will provide preliminary evidence for treatment targets for novel interventions for adolescent girls—e.g., a response inhibition intervention may be needed during phases of the menstrual cycle characterized by specific hormonal profiles.