Biobehavioral Effects of Inhibitory Control on Eating and Diet Behaviors Among Adolescents

1个项目摘要/摘要 2本K01职业发展奖申请书建议培训和研究，旨在提供 具备独立调查员职业生涯基础的候选人，具备以下专业知识 4终生肥胖发生和发展的生物行为机制。这个 5候选人建议进行培训，以提供三个领域的新专业知识，包括(1)儿童和 6青少年肥胖预防研究；(2)饮食与肥胖的基础和评估；(3)理论 7、神经科学和神经影像学方法。利用这次培训，将在#年开展一个研究项目。 8应用培训的顺序。目前的应用程序建议使用生物行为、多方法方法 9整合神经影像和生态瞬间评估(EMA)在青少年样本中的研究 10抑制控制和环境因素如何影响青春期的饮食和饮食摄入行为， 11，这是一个关键的过渡发展时期。关于抑制性控制的先前研究的局限性 肥胖症包括：(1)未能检查抑制控制和抑制控制之间的人内(瞬间)联系 13饮食行为；(2)初步研究抑制控制及其对饮食的影响 14实验室中的摄入行为；(3)缺乏对IC的神经生物学基础的了解 15有助于实时进食和饮食摄取行为；(4)未能研究背景因素如何调节 16抑制性控制与进食和饮食摄入行为之间的联系；以及(5)缺乏对 17岁青春期。这一使用神经成像和EMA的拟议方法将允许阐明：大脑- 18条基于抑制控制缺陷的通路，以及这些基于大脑的通路如何映射到真实的- 19世界饮食和饮食摄取行为；抑制性控制的人内波动是如何关联的 20与一天中的饮食和饮食摄取行为有关；以及动态环境因素(例如， 21影响、社会环境和高度美味食物的可获得性)，修改抑制性之间的关联 22控制进食和饮食摄入行为。这项研究将推出候选人的独立 23项研究计划侧重于阐明人与人之间的生物行为机制 24.一生中肥胖的发展和进展，这将转化为综合 25个考虑到个体差异因素和背景因素的预防方案。

1 PROJECT SUMMARY/ABSTRACT 2 This K01 career development award application proposes training and research designed to provide the 3 candidate with the foundation to establish a successful career as an independent investigator with expertise in 4 biobehavioral mechanisms underlying development and progression of obesity across the lifespan. The 5 candidate proposes training to provide new expertise and knowledge in three areas including (1) child and 6 adolescent obesity prevention research; (2) foundations and assessment of diet and obesity; and (3) theory 7 and methods of neuroscience and neuroimaging. Using this training, a research project will be conducted in 8 order to apply training. The current application proposes to use a biobehavioral, multi-method approach 9 integrating neuroimaging and ecological momentary assessment (EMA) in a sample of adolescents to study 10 how inhibitory control and contextual factors influence eating and dietary intake behaviors during adolescence, 11 which is a critical transitional developmental period. Limitations of previous research on inhibitory control and 12 obesity includes (1) failure to examine within-person (momentary) associations between inhibitory control and 13 eating and dietary intake behaviors; (2) primarily studying inhibitory control and its effect on eating and dietary 14 intake behaviors in the laboratory; (3) lack of understanding of how neurobiological underpinnings of IC 15 contribute to real-time eating and dietary intake behaviors; (4) failure to study how contextual factors moderate 16 the link between inhibitory control and eating and dietary intake behaviors; and (5) lack of research on 17 adolescence. This proposed approach using neuroimaging and EMA will allow for the elucidation of: brain- 18 based pathways that underlie deficits in inhibitory control, and how these brain-based pathways map onto real- 19 world eating and dietary intake behaviors; how within-person fluctuations in inhibitory control are associated 20 with eating and dietary intake behaviors over the course of the day; and how dynamic contextual factors (e.g., 21 affect, social environment, and availability of highly palatable foods), modify the association between inhibitory 22 control and eating and dietary intake behaviors. This research will launch the candidate’s independent 23 research program focused on elucidating within- and between-person biobehavioral mechanisms underlying 24 the development and progression of obesity across the lifespan, which will be translated to integrated 25 prevention programs that take into account individual difference factors and contextual factors.