Biobehavioral Effects of Inhibitory Control on Eating and Diet Behaviors Among Adolescents

1项目概要/摘要 2此K 01职业发展奖申请建议培训和研究旨在提供 3名候选人与基金会建立一个成功的职业生涯作为一个独立的调查员与专业知识， 肥胖症在整个生命周期中发展和进展的4种生物行为机制。的 5名候选人提出培训，以提供三个领域的新专业知识和知识，包括（1）儿童和 6青少年肥胖预防研究;（2）饮食与肥胖的基础和评估;（3）理论 7和神经科学和神经成像方法。利用这一培训，将开展一个研究项目， 8、接受培训。本申请提出使用生物行为的多方法方法 9在青少年样本中整合神经影像学和生态瞬时评估（EMA）进行研究 10抑制控制和环境因素如何影响青春期的饮食和饮食摄入行为， 11是一个关键的转型发展时期。以往抑制控制研究的局限性， 12肥胖包括（1）未能检查抑制控制和 （2）初步研究抑制控制及其对进食和饮食行为的影响 实验室中的14种摄入行为;（3）缺乏对IC神经生物学基础的理解 15有助于实时进食和饮食摄入行为;（4）未能研究环境因素如何调节 16抑制控制与进食和饮食摄入行为之间的联系;以及（5）缺乏对 17青春期。这种使用神经成像和EMA的拟议方法将允许阐明：脑- 18个基于抑制控制缺陷的通路，以及这些基于大脑的通路如何映射到真实的- 19世界饮食和饮食摄入行为;如何在抑制控制的人内波动相关联 20与一天中的进食和饮食摄入行为;以及动态背景因素（例如， 21影响，社会环境，和高度可口的食物的可用性），修改之间的关联抑制 22控制和饮食摄入行为。这项研究将启动候选人的独立 23项研究计划，重点是阐明人内和人与人之间的生物行为机制 24整个生命周期中肥胖的发展和进展，这将转化为综合的 25个预防方案，考虑到个人差异因素和背景因素。

1 PROJECT SUMMARY/ABSTRACT 2 This K01 career development award application proposes training and research designed to provide the 3 candidate with the foundation to establish a successful career as an independent investigator with expertise in 4 biobehavioral mechanisms underlying development and progression of obesity across the lifespan. The 5 candidate proposes training to provide new expertise and knowledge in three areas including (1) child and 6 adolescent obesity prevention research; (2) foundations and assessment of diet and obesity; and (3) theory 7 and methods of neuroscience and neuroimaging. Using this training, a research project will be conducted in 8 order to apply training. The current application proposes to use a biobehavioral, multi-method approach 9 integrating neuroimaging and ecological momentary assessment (EMA) in a sample of adolescents to study 10 how inhibitory control and contextual factors influence eating and dietary intake behaviors during adolescence, 11 which is a critical transitional developmental period. Limitations of previous research on inhibitory control and 12 obesity includes (1) failure to examine within-person (momentary) associations between inhibitory control and 13 eating and dietary intake behaviors; (2) primarily studying inhibitory control and its effect on eating and dietary 14 intake behaviors in the laboratory; (3) lack of understanding of how neurobiological underpinnings of IC 15 contribute to real-time eating and dietary intake behaviors; (4) failure to study how contextual factors moderate 16 the link between inhibitory control and eating and dietary intake behaviors; and (5) lack of research on 17 adolescence. This proposed approach using neuroimaging and EMA will allow for the elucidation of: brain- 18 based pathways that underlie deficits in inhibitory control, and how these brain-based pathways map onto real- 19 world eating and dietary intake behaviors; how within-person fluctuations in inhibitory control are associated 20 with eating and dietary intake behaviors over the course of the day; and how dynamic contextual factors (e.g., 21 affect, social environment, and availability of highly palatable foods), modify the association between inhibitory 22 control and eating and dietary intake behaviors. This research will launch the candidate’s independent 23 research program focused on elucidating within- and between-person biobehavioral mechanisms underlying 24 the development and progression of obesity across the lifespan, which will be translated to integrated 25 prevention programs that take into account individual difference factors and contextual factors.