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Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour

Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour
实现将药物靶向输送至女性子宫肌以预防早产
批准号:
nhmrc : 1113847
负责人:
A/Pr Susan Hua
金额:
$32.25万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Development Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

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项目成果

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中文摘要
翻译
我们拥有针对子宫的专利脂质体,这使我们能够将药物专门输送到子宫的肌肉细胞,从而增加安全性。脂质体可以装载阻止或促进宫缩的药物,创造出一种多功能的药物输送系统,可以治疗早产或产后出血,这些都是主要的临床问题。我们寻求支持,以在人类研究之前,在小鼠和灵长类动物早产模型中证明它们的有效性。
英文摘要
We have patented liposomes targeted to the uterus, which enable us to deliver drugs specifically to the muscle cells of the uterus, increasing safety. The liposomes can be loaded with drugs that either block or promote contractions, creating a versatile drug delivery system that could treat premature labour or postpartum haemorrhage which are major clinical problems. We seek support to demonstrate their effectiveness in mouse and primate models of preterm labour prior to human studies.
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会议论文
Understanding the regulation of hERG potassium channel in the myometrium at the time of labour
  • 批准号:
    nhmrc : 1050584
  • 项目类别:
    Project Grants
  • 资助金额:
    $39.85万
  • 财政年份:
    2013
  • 负责人:
    A/Pr Susan Hua
  • 依托单位:
Peripheral mechanisms of analgesia and the involvement of cell adhesion
  • 批准号:
    nhmrc : 456314
  • 项目类别:
    NHMRC Postgraduate Scholarships
  • 资助金额:
    $4.67万
  • 财政年份:
    2007
  • 负责人:
    A/Pr Susan Hua
  • 依托单位:
国内基金
海外基金
柳枝稷miR156-targeted PvSPLs调控木质素合成的分子机制研究
miR156-targeted PvSPL转录因子调控柳枝稷分蘖发育的分子机制