Multi-Consortia Coordinating Center (MC2 Center) for Cancer Biology: Building Interdisciplinary Scientific Communities, Coordinating Impactful Resource Sharing, and Advancing Cancer Research

项目摘要 系统生物学一直是克服生物医学研究中挑战的一种工具方法，其中 解决方案源于跨学科的努力、共享的资源(数据、工具、模型、专业知识)和 分析。NCI癌症生物学分部(DCB)成立了多个由跨学科组成的联合体 致力于集成方法、数据和工具以解决以下重要问题的科学家社区 基础和转化型癌症研究。多联盟协调(MC2)癌症生物学中心将 跨计划合作，以促进参与和协作、支持资源共享和传播 向更广泛的科学界提供知识和资源。 MC2中心将通过三个枢纽运营。协作中心将使用基于证据的策略来 促进互动和新的合作。将制定一个评价框架，包括量化和 定性指标，以确保中心不断提高其影响力。社区参与活动将 包括工作小组、特殊兴趣小组、梦想挑战和思维障碍，所有这些都将 确保包容性和促进多样性的机制。促进DCB的资源共享 资源协调中心将确保所有资源都是可查找、可访问、可互操作和 可重复使用(公平)；它将确定或制定公开和公平的标准和最佳做法；提供关于 如何在癌症研究界实施这些标准和实践；并提供工具和 接口，以促进资源共享、管理和存放在公共存储库中。最后，外展 中心将通过培训材料加强知识和资源的传播，以最大限度地利用 工具、短期课程和研讨会，从DCB计划中带来概念和资源 一起，使更广泛的社区能够体验到综合跨学科方法的力量 致癌。 癌症复杂性知识门户将继续提供对所有数据、工具和其他 通过DCB和MC2生成的资源，突出了发现并支持对 DCB计划产生的许多有价值的资源。

Project Summary Systems Biology has been an instrumental approach to overcoming challenges in biomedical research, where solutions arise from interdisciplinary efforts, shared resources (data, tools, models, expertise) and integrative analyses. The NCI Division of Cancer Biology (DCB) has created multiple consortia comprising interdisciplinary communities of scientists who aim to integrate approaches, data, and tools to address important questions in basic and translational cancer research. The Multi-Consortia Coordinating (MC2) Center for Cancer Biology will work across programs to motivate engagement and collaboration, support resource sharing, and disseminate knowledge and resources to the broader scientific community. The MC2 Center will operate through three hubs. The Collaboration Hub will use evidence-based strategies to catalyze interactions and new collaborations. An evaluation framework will be developed with quantitative and qualitative metrics to ensure the center continuously improves its impact. Community engagement activities will include working groups, special interest groups, DREAM Challenges, and Ideation Jams, all of which will have mechanisms for ensuring inclusion and promoting diversity. To facilitate sharing of resources from DCB programs, the Resource Coordination Hub will ensure all resources are findable, accessible, interoperable and reusable (FAIR); it will identify or develop open and FAIR standards and best practices; provide training on how to implement these standards and practices in the cancer research community; and provide tooling and interfaces to facilitate resource sharing, curation, and deposition in public repositories. Finally, the Outreach Hub will enhance dissemination of knowledge and resources through training materials to maximize utilization of tools and short courses and workshops that bring concepts and resources from across the DCB programs together, enabling the broader community to experience the power of an integrative interdisciplinary approach to cancer. The Cancer Complexity Knowledge Portal will continue to provide open access to all data, tools, and other resources generated through the DCB and MC2, highlighting discoveries and enabling exploration into the many valuable resources generated by DCB programs.