Impacts of Early Life Food Insecurity on Child Obesity and Cognitive Development Trajectories

项目摘要/摘要 粮食不安全是一个重大的公共卫生问题，其定义是有限或不确定地获得足够的 积极健康的生活方式的食物。粮食不安全影响了15.7%的美国有孩子的家庭， 但它对儿童生长和发育轨迹的影响并未得到很好的记录。在这条K99/R00路径中 对于独立奖项目，我提出的研究目的是更好地了解早期生活中食物的影响 对儿童成长和发展的不安全。我将利用两项正在进行的出生队列研究的数据 哥伦比亚儿童环境健康中心(CCCEH)评估粮食不安全的影响 怀孕和儿童早期间歇性和持续性的食物不安全1)母体肥胖和 认知功能；2)儿童成长和认知发展轨迹 18.这将是第一项同时检查粮食不安全轨迹在儿童和儿童中的作用的研究 青春期认知发展与肥胖。这项研究将结合尖端的身体成分 测量、认知评估和流行病学方法，并将对 关于食物不安全的知识--肥胖和食物不安全--儿童认知功能的联系 和青少年。这项工作还将提供新的见解，为基于证据的建议和 针对儿童和青少年肥胖的干预措施。在K99阶段，我的工作将位于顶端- 哥伦比亚大学梅尔曼公共卫生学院、CCCEH和纽约肥胖研究所的层级研究环境 研究中心，所有这些都非常注重政策翻译和社区合作。定位 我在专注于政策翻译和分析的研究环境中的K99/R00工作将为我提供 在研究结果和数据如何有助于政策辩论和产生方面的经验和培训 新的数据驱动策略。K99/R00的培训目标是熟练掌握复杂的纵向数据 利用生物阻抗和磁学技术对儿童和青少年进行分析和身体成分评估 共振成像，使用诊断测试的儿童认知发展评估，以及收集和分析 出生队列中的定量数据。作为R00阶段的一部分，我将在收集方面获得现场经验 儿童的人体测量和认知数据。这项工作是我先前和正在进行的工作的逻辑延伸 研究肥胖、营养和食品不安全，并将填补我作为职业生涯起步所需的培训空白 一位在流行病学、城市卫生和社会政策的交叉领域工作的独立科学家。

PROJECT SUMMARY/ABSTRACT Food insecurity is a significant public health concern and is defined as limited or uncertain access to enough food for an active and healthy lifestyle. Food insecurity impacts 15.7% of households with children in the U.S., but its effects on child growth and developmental trajectories are not well documented. In this K99/R00 Pathway to Independence Award project, I propose research aims to better understand the impact of early life food insecurity on child growth and development. I will utilize data from two ongoing birth cohort studies at the Columbia Center for Children's Environmental Health (CCCEH) to assess the effects of food insecurity during pregnancy and intermittent and persistent food insecurity during early childhood on 1) maternal obesity and cognitive function, and 2) childhood growth and cognitive development trajectories from early childhood to age 18. This will be the first study to simultaneously examine the role of food insecurity trajectories in child and adolescent cognitive development and obesity. This research will combine cutting edge body composition measurement, cognitive assessment and epidemiologic methods and will contribute important substantive knowledge on the food insecurity-obesity and the food insecurity-cognitive function associations within children and adolescents. This work will also provide novel insight to inform evidence-based recommendations and interventions around child and adolescent obesity. During the K99 phase, my work will be situated within the top- tier research environments of Columbia's Mailman School of Public Health, the CCCEH and the NY Obesity Research Center, all of which have a strong focus on policy translation and community partnerships. Situating my K99/R00 work in a research environment focused on policy translation and analysis will provide me with experience and training in how research findings and data can contribute to policy debates and to the generation of new data driven policies. The training goals of this K99/R00 are to become skilled in complex longitudinal data analyses, body composition assessment in children and adolescents using bio-impedance and magnetic resonance imaging, child cognitive development assessment using diagnostic tests, and collection and analysis of quantitative data within a birth cohort. As part of the R00 phase, I will gain field experience in collecting anthropometric and cognitive data from children. This work is a logical extension of my prior and ongoing research in obesity, nutrition and food insecurity, and will fill gaps in training that I need to launch my career as an independent scientist working at the intersection of epidemiology, urban health and social policy.