WashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational Center

项目总结 人体组织体细胞嵌合体(SMAHTT)网络旨在推动发现新的 由体细胞组织中的基因组变异所调节的人类健康和疾病的生物学过程。 高效、有效的后勤和科学协调对于实现SMAHT网络数据的最大价值至关重要。 我们建议建立华盛顿大学SMAHTT计划组织中心(SMAHTOC)。我们的建议 结合了三个关键优势：1)在基因组学、生物信息学和基因组变异方面具有广泛而深厚的专业知识； 2)华盛顿大学管理团队之间紧密的合作关系；以及3)长期担任 构建基因组资源联盟，包括Roadmap、ENCODE、4DN、TARGET、CCDG、Human Pangenome Project和IGVF。华盛顿大学SMAHTOC将成为促进以下各项活动的核心 斯马特网络。我们将定义沟通的规则和机制，并将授权研究人员 参与多式联运的“生物大数据”。我们将开发和组织管理、网络、报告 建立高效和协同的网络业务的方法和定期会议。我们将提供 行政支助，以确保与SMATH网络有关的资源、数据和其他产品可用 对社区的影响。我们将协调所有网络会议和工作组，包括启动会议 和年度会议。我们将建设和管理内部和外部SMATH网络网站，这将 要根据社区需求不断发展。我们将整合SMATH网络并向其注入信息 以及来自其他大型资源和项目的数据，通过导航数据共享需求和协调 与其他财团的合作。我们将扩展WASHU Eigenome的成功IT基础设施 协调数据可视化工作的浏览器，使科研界能够充分利用 斯马特网络的成员。我们将为发展和管理提供行政和预算支持 参与和培训，包括协调网络内外研究人员的机会。 华盛顿大学SMAHTOC将整合不同SMAHTT网络所有资助倡议的努力， 通过创新方法，建立促进合作、协调、 以及网络参与者和科学界之间的交流。 。

PROJECT SUMMARY The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to propel discovery of new biological processes in human health and disease that are mediated by genomic variation in somatic tissues. Efficient and effective logistical and scientific coordination is vital to maximizing value of SMaHT Network data. We propose to establish the WashU SMaHT Program Organizational Center (SMaHT-OC). Our proposal combines three key strengths: 1) broad and deep expertise in genomics, bioinformatics and genome variation; 2) strong collaborative ties among the WashU management team; and 3) longstanding experience as leaders of consortia building genomic resources, including Roadmap, ENCODE, 4DN, TaRGET, CCDG, Human Pangenome Project, and IGVF. The WashU SMaHT-OC will serve as the nucleus for facilitating all activities of the SMaHT Network. We will define rules and mechanisms of communication, and will empower researchers to engage with multimodal "big bio-data". We will develop and organize management, networking, reporting methods, and regular meetings for establishing efficient and synergistic Network operations. We will provide administrative support to ensure that SMaHT Network-related resources, data and other products are available to the community. We will coordinate all Network meetings and working groups, including the Kick-Off meeting and annual meetings. We will build and manage both internal and external SMaHT Network websites, which will be designed to evolve with community needs. We will integrate and infuse the SMaHT Network with information and data from other large-scale resources and projects by navigating data sharing requirements and coordinating collaborations with other consortia. We will extend the successful IT infrastructure of the WashU Epigenome Browser to coordinate data visualization efforts to enable the scientific research community to take full advantage of the SMaHT Network. We will provide administrative and budget support for developing and managing engagement and training, including coordinating opportunities for researchers within and outside the Network. The WashU SMaHT-OC will integrate the efforts of all the funded initiatives of the diverse SMaHT Network, and, through innovative methodology, establish a research environment that promotes collaboration, coordination, and communication among Network participants and the scientific community. .