A Pipeline for Research, Education and Mentoring in Reproductive Aging

生殖老龄化研究、教育和指导管道 女性生育能力下降是人类最早出现的与年龄相关的恶化之一，通常发生在几十年前 出现躯体衰老的迹象。从生育的角度来看，30多岁的女性被认为是老年人， 只有约5%的人在40多岁时成功自然怀孕。除了生育能力，更年期还会引发 一系列负面健康结果，包括认知能力下降的易感性增加， 心血管疾病人类预期寿命增加，加上生育推迟的全球趋势 这意味着生殖健康不仅对妇女的健康、生活和职业选择很重要， 不可避免的社会、经济和公共卫生影响。越来越多的证据表明， 生殖衰老和身体衰老在机制上密切相关。在过去的二十年里， 来自NIA和其他人的支持，导致了从基本的生物衰老到生物衰老的无数发现。 潜在的抗衰老疗法的机制。然而，生殖老化仍然研究不足， 公共卫生的重要性认识不足。培养一支知识型的劳动力队伍， 人口老龄化的当前和未来挑战，迫切需要优先考虑老龄化的交叉点， 生殖是研究、教育和生物医学项目的重点。 博士Ghazi建议通过建立K 07学术领导职业奖来满足这一需求， 生殖老化研究，教育和指导（PRAM）的管道，跨越 匹兹堡大学（皮特）的本科生到教师的光谱。此应用程序的中心目标是 创建一个程序，将有助于建立皮特作为一个世界领先的生殖老化。K 07领导奖 将通过促进在大学建立一个“管道”来帮助实现这一目标， (Aim 1）：吸引早期学术阶段的学生从事生殖老化研究，（B） 教育（目标2）：组织一个以生殖健康和老龄化为重点的强有力的教育课程，以及 持续导师制（目标3）：为以下人士提供个人化、长期的导师制和社区支持： 研究人员在这一领域的每一个职业阶段。加齐博士是领导这一倡议的独特地位，因为 她在衰老、生殖及其交叉领域的长期研究专长， 经验和对教育和指导的承诺。皮特是这一倡议的理想机构，因为 专门致力于老龄化和生殖健康研究的备受推崇的中心的存在， 一个示范性的研究和资助记录，以及一个大型的，多样化的本科生，研究生和医学人才库 学生Pitt-PRAM将有助于将生殖老龄化作为皮特的核心机构目标，并作为 一个路线图，以建立一个训练有素的生殖老年科学的未来劳动力。

A Pipeline for Research, Education and Mentoring in Reproductive Aging Decline in female fertility is one of the earliest age-related deteriorations seen in humans, often decades before signs of somatic aging appear. From a fertility perspective, women are considered geriatric by late 30s and only ~5% experience successful natural pregnancies in their 40s. Besides fertility, menopause triggers a spectrum of negative health outcomes including increased susceptibility to cognitive decline and cardiovascular disease. Increased human life expectancy coupled to global trends of delayed child-bearing means that reproductive fitness is not only important for womens’ health, life- and career- choices, but has inescapable societal, economic and public-health implications. An expanding body of evidence reveals that reproductive senescence and somatic aging are mechanistically intimately linked. In the last two decades, support from the NIA, and others, has led to innumerable discoveries in organismal aging from basic mechanisms to potential anti-aging therapeutics. However, reproductive aging remains under-studied and its public-health significance poorly acknowledged. To develop an intellectual workforce well equipped to meet the current and future challenges of an aging population, it is critical to urgently prioritize the intersection of aging and reproduction as a focus of research, education and biomedical programs. Dr. Ghazi proposes to address this need through this K07 Academic Leadership Career award, by establishing a Pipeline for Reproductive-Aging Research, Education & Mentorship (PRAM) that spans the undergraduate-to-faculty spectrum at the University of Pittsburgh (Pitt). The central goal of this application is to create a program that will help establish Pitt as a world leader in reproductive aging. The K07 leadership award will help attain this goal by facilitating the development of a ‘pipeline’ at the university for (a) Early Recruitment (Aim 1): attract students from early academic stages towards reproductive-aging research, (b) Exceptional Education (Aim 2): organize a strong educational curriculum focused on reproductive health and aging, and (c) Sustained Mentorship (Aim 3): provide personalized, long-term mentorship and community support for researchers in this area at every career stage. Dr. Ghazi is uniquely positioned to lead this initiative because of her long-standing research expertise in aging, reproduction and their intersection, her academic leadership experience and commitment to education and mentoring. Pitt is an ideal institution for this initiative because of the presence of highly-regarded centers specifically dedicated to research on aging and reproductive health, an exemplary research and funding record, and a large, diverse pool of undergraduate, graduate and medical students. Pitt-PRAM will help establish reproductive aging as a core institutional objective at Pitt and serve as a roadmap to build an exceptionally trained Reproductive Geroscience workforce of the future.