Translating pharmacokinetic and pharmacodynamic data to better design new drugs for the treatment of Trypanosoma cruzi infection

目前迫切需要治疗克氏t型虫感染的新药，但由于对宿主-寄生虫复杂相互作用的不完全了解、在药物发现过程中缺乏严格定义活性的体外和体内工具以及对浓度/效应关系的认识不足，这些药物的设计一直受到阻碍。本项目旨在开发新的和急需的体外方法，以更好地确定新的候选药物的动力学和动力学活性，并为将这些信息转化为长期的克氏T.感染动物模型提供合理的基础。结果旨在合理设计候选药物，在较短的时间内获得，并适合进一步开发。

New drugs to treat T. cruzi infection are urgently needed, however their design has been hampered by an incomplete understanding of complex host-parasite interactions, inadequate in vitro and in vivo tools to rigorously define activity during drug discovery, and a poor appreciation of concentration/effect relationships. This project aims to develop new and much needed in vitro methods to better define the kinetic and dynamic activity of new drug candidates, and will provide a rational basis for translating this information into lengthy animal models of T. cruzi infection. The outcome aims to be rationally designed drug candidates that are available in a shorter period of time and are suitable for further development.