Mentoring patient-oriented research to improve cardiovascular health among people with HIV in sub-Saharan Africa

项目摘要 概况.这个K24职业中期研究者奖将支持Mark Siedner博士领导一个指导计划 在艾滋病毒感染者中检测和预防心血管疾病的以患者为导向的研究中， 撒哈拉以南非洲 候选人Siedner博士是一名医生科学家，担任四个NIH的首席研究员（PI）或共同PI R 01资助的撒哈拉以南非洲艾滋病毒和/或心血管疾病患者导向研究（POR）项目 非洲，产生了220多份经同行审查的出版物。他也证明了自己是一个非常成功的 导师，有二十多个过去和现在的学员，收到哈佛医学院青年导师 该奖项，并证明了他的作用，作为一个美国国立卫生研究院T32计划在艾滋病毒临床研究在MGH（T32 AI 007433），乌干达（D43）多药耐药全球D43临床研究培训项目的研究中心PI TW 011632），以及Fogarty临床研究奖学金（D43 T010543）的项目导师。 指导计划。这个K24奖项将使Siedner博士能够保护他25%的时间用于培训 美国和撒哈拉以南非洲地区的初级研究人员参与了与心血管疾病预防相关的POR 艾滋病病毒携带者中。他将利用通过以下方式确定的临床研究受训人员的既定渠道 他在培训赠款方面的领导作用，并正式制定了全球心血管疾病研究培训计划， 该项目侧重于职业发展，并将美国和非洲科学家与合作项目配对。 研究计划。Siedner博士将利用该奖项提供的支持， 机器学习和临床风险预测。他将利用机器学习培训和合作伙伴关系 与数据科学专家合作，全面评估和验证单个诊断和组合诊断 撒哈拉以南非洲艾滋病毒感染者心血管疾病筛查模式（目标1和2）。 这将通过NHLBI资助的R 01的数据实现，其中包括CT血管造影和广泛的 乌干达600人的风险因素数据。在第二个项目中，他将使用风险预测技术， 推导并验证南非HIV感染者的心血管疾病风险预测评分（Aim 3）。这将通过一项由惠康信托基金会资助的、基于人群的、纵向队列研究得以实现， 南非18，000人完成心血管疾病筛查并接受随访， 住院和死亡。拟议的工作直接符合NIH中概述的研究优先事项，而不是 020-013，包括预防整个生命周期中的艾滋病毒共病状况， 多学科的劳动力。此外，西德纳博士长期致力于培训初级科学家， POR，特别是他致力于促进妇女和个人的职业生涯， 在科学界的代表，使他成为这个奖项的优秀候选人。

PROJECT SUMMARY Overview. This K24 mid-career investigator award will support Dr. Mark Siedner to lead a mentoring program in patient-oriented research on detection and prevention of cardiovascular disease among people with HIV in sub-Saharan Africa. Candidate. Dr. Siedner is a physician scientist who serves as principal investigator (PI) or co-PI of four NIH R01-funded patient-oriented research (POR) projects on HIV and/or cardiovascular disease in sub-Saharan Africa, leading to over 220 peer-reviewed publications. He has also proven himself to be a highly successful mentor, with over two dozen past and current trainees, receipt of the Harvard Medical School Young Mentor Award, and evidenced by his role as co-director of an NIH T32 program in HIV clinical research at MGH (T32 AI007433), site PI of a global D43 clinical research training program on multimorbidity in Uganda (D43 TW011632), and program mentor in the Fogarty Clinical Research Fellowship (D43 T010543). Mentoring plan. This K24 award will allow Dr. Siedner to protect 25% of his time to be dedicated for training junior investigators in the US and sub-Saharan Africa in POR related to cardiovascular disease prevention among people with HIV. He will leverage an established pipeline of clinical research trainees identified through his leadership role on training grants and formalize a global cardiovascular disease research training program that focuses on career advancement and pairs US and African scientists with collaborative projects. Research Plan. Dr. Siedner will use the support provided by this award to pursue mid-career training in machine learning and clinical risk prediction. He will leverage the machine learning training and partnerships with experts in data science to comprehensively assess and validate individual and combinations of diagnostic screening modalities for cardiovascular disease among people with HIV in sub-Saharan Africa (Aims 1 and 2). This will be made possible with data from an NHLBI-funded R01 that includes CT angiography and extensive risk factor data in 600 individuals in Uganda. In a second project, he will use risk prediction techniques to derive and validate cardiovascular disease risk prediction scores among people with HIV in South Africa (Aim 3). This will be made possible by a Wellcome Trust-funded, population-based, longitudinal cohort study of over 18,000 people in South Africa who completed cardiovascular disease screening and are followed until hospitalization and death. The proposed work is directly in line with research priorities outlined in NIH NOT- 020-013 including prevention of HIV co-morbid conditions across the lifespan and research training of a multidisciplinary workforce. Moreover, Dr. Siedner’s longstanding commitment to training junior scientists in POR, and particularly his dedication to the advancement of careers of women and individuals under- represented in science, make him an excellent candidate for this award.