Remediation of Perfluorinated Chemicals in Water Using Novel High-Affinity Polymer Adsorbents

摘要 有毒的全氟烷基和多氟烷基物质对供水的污染是一个主要的健康和环境问题， 影响当今社会的问题。鉴于这些污染物的环境持久性及其既定的 与严重的健康风险联系在一起，安全，高效和具有成本效益的PFAS补救措施势在必行 开发技术，可以消除美国供水中的这些污染物。与 收紧基于健康的污染限制和扩大受监管的PFAS结构， PFAS污染现在估计影响超过2亿美国人。NIEHS赞助的DEXSORB 吸附剂代表了一种突破性的解决方案，用于安全，快速和具有成本效益的去除短-和长- 链全氟辛烷磺酸化合物，包括水中的全氟辛酸和全氟辛烷磺酸。去除PFAS需要严格的技术 在微量水平的化合物被强制要求由国家和环保局。由可再生环糊精制成， DEXSORB在痕量浓度下选择性靶向PFAS化合物的能力， 容量和抗结垢性使其非常适合用于私人和市政水处理系统。 通过与环保合作伙伴的合作，Cyclopure展示了其上级性能和良好的使用寿命。 DEXSORB在水处理试验活动中的循环经济。为了进一步推进具体的里程碑， 完成后将有助于Cyclopure过渡到完全商业化阶段，已在本CRP中确定 提议Cyclopure在该计划中的主要目标是寻求监管和制造方面的支持 援助.在开始全面生产和商业化之前，这两个领域都至关重要 活动将收集和整理与安全和健康相关的信息以及相关的实验数据 用于包括EPA和NSF在内的监管机构要求的材料注册和认证 国际化.在制造援助下开展的活动将支持开发最佳净化方法 这有望在全尺寸制造环境中提供显著的成本和工艺改进。 成功完成这项拟议的工作将使Cyclopure过渡到大规模生产， 与行业合作伙伴合作，使DEXSORB可用于为消费者和市政提供PFAS清除 应用.

Abstract Contamination of water supplies by toxic per- and polyfluoroalkyl substances is a major health and environmental issue impacting society today. Given the environmental persistence of these contaminants and their established linkage to serious health risks, it is imperative that safe, efficient, and cost-effective PFAS remediation technologies be developed that can eliminate these contaminants from the U.S. water supplies. With the tightening of health-based contamination limits and the expansion of regulated PFAS structures, the impacts of PFAS contamination are now estimated to affect over 200 million Americans. NIEHS sponsored DEXSORB adsorbent represents a breakthrough solution for the safe, rapid, and cost-effective removal of short- and long- chain PFAS compounds, including PFOA and PFOS from water. It takes exacting technology to remove PFAS compounds at the trace levels being mandated by States and the EPA. Made from renewable cyclodextrins, DEXSORB’s ability to selectively target PFAS compounds at trace concentrations with rapid uptake, high capacity, and resistance to fouling make it ideally suited for use in private and municipal water treatment systems. Working with environmental partners, Cyclopure has demonstrated the superior performance and favorable life cycle economies of DEXSORB in pilot water treatment activities. To advance further, specific milestones that upon completion will help Cyclopure transition to full commercialization stage have been identified in this CRP proposal. Cyclopure’s main objective in this program will be to seek support for regulatory and manufacturing assistance. Both areas are critical prior to the commencement of full-scale manufacturing and commercialization activities. Safety and health related information and associated experimental data will be collected and organized for material registrations and certifications as required by regulatory agencies including EPA and NSF International. Activities under manufacturing assistance will support developing an optimal purification method that is expected to provide significant cost and process improvements in a full-scale manufacturing environment. Successful completion of this proposed work will enable Cyclopure to transition to large-scale production and work with industry partners to make DEXSORB available to provide PFAS removal for consumer and municipal applications.