Pilot Projects Program

计划摘要/摘要-STEM单元和老化Cobre试点资助计划 在我们第一阶段和第二阶段Cobre计划的成功基础上，我们提出了干细胞和衰老(SCA) Cobre Pilot Grants计划，旨在通过以下方式招募有前途的早期调查团队 为试点项目提供资金机制，并提供智力、技术和工具 基础设施。在具体目标1中，我们将选择翻译研究人员团队(由基础和临床组成 科学家，至少有一名早期研究员)获得3个试点项目奖(2年内每年50,000美元，以及 在整个计划期间至少有6个奖项)，并为以下学生提供额外的暑期津贴 代表群体，以增强多样性。征求建议书将集中在具有很大潜力的项目上 将基础研究转化为临床实践。在具体目标2中，我们将提供系统的、正式的指导 (由资深、医疗外资助的研究人员提供)，用于参与早期基础和临床医生科学家 研究人员专注于干细胞和衰老研究、再生医学和与年龄相关的疾病，以 利用外部资金促进他们向研究独立的过渡。在具体目标3中，我们将推动 政制事务局局长科布雷核心设施的使用率和可持续性(在第一和第二阶段开发，包括 流式细胞术、胞外囊泡、慢病毒构建核心设施)在试点中的应用 项目以及通过向参与该计划的附属科学家发放代金券。在具体目标4中，我们 将为项目获奖者提供获奖后的指导、咨询和资助金服务，并协同 努力将资助的项目转化为R01或同等级别的竞争性申请。重点将是 建立在严谨、可重现的科学之上，分析得到专业生物统计学家的支持，指导 参与研究的人员。该计划的核心将依赖于SCA试点赠款计划指导的工作 委员会将提供指导和监督，并参与(确定早期调查人员， 用于审查试点奖项和专家指导)跨多机构的研究人员社区 由布罗大学(老龄化生物学中心、布朗癌症中心和生命癌症中心)组成的财团， 沃伦·阿尔伯特医学院，来自生命医疗保健/罗德岛医院的临床专家和 来自新英格兰关爱中心。通过建立多学科科学基础设施，提供访问国家 最先进的仪器和技术，以及严格的指导、建议、审查和结果 指导下，SCA Cobre第三阶段试点赠款计划将有助于扩大和转变 罗德岛州的生物医学和教育景观，创建了一个主要的国家研究中心 干细胞、衰老和再生医学。我们将使用结果衡量标准对该计划进行评估，包括 提交材料的数量和质量(以审查分数衡量)、导师和调查员评估以及 申请者的多样性和成功获得校外奖项。

PROGRAM SUMMARY/ABSTRACT - STEM CELL AND AGING COBRE PILOT GRANT PROGRAM Building on the success of our Phase 1 and 2 COBRE program, we propose the Stem Cells and Aging (SCA) COBRE Pilot Grants Program with an objective to recruit promising teams of early-stage investigators by providing a funding mechanism for pilot projects and provide intellectual, technical and instrumental infrastructure. In Specific Aim 1, we will select teams of translational researchers (consisting of basic and clinical scientists, with at least one early-stage investigator) for 3 pilot project awards ($50,000 per year for 2 years and minimum of 6 awards for the duration of the program), with additional summer stipends for students from under- represented groups to enhance diversity. The request for proposals will focus on projects with high potential of translating basic research into clinical practice. In Specific Aim 2, we will provide structured, formal mentorship (provided by senior, extramurally-funded investigators) for participating early-stage basic- and clinician-scientist investigators focused on stem cell and aging research, regenerative medicine and age-related diseases to facilitate their transition to research independence with extramural funding. In Specific Aim 3, we will promote the utilization and sustainability of the SCA COBRE Core Facilities (developed in Phases 1 and 2, and including Flow Cytometry, Extracellular Vesicles, Lentiviral Construct Core Facilities) through their utilization in the pilot projects as well as through vouchers to affiliated scientists participating in the program. In the Specific Aim 4, we will provide post-award mentorship, advisory and grantsmanship services for program awardees, and synergize efforts to transform funded projects into competitive applications at the R01 or equivalent level. Emphasis will be placed on rigorous, reproducible science with analysis supported by expert biostatisticians guiding the participating researchers. The core of the program will rely on the work of the SCA Pilot Grants Program Steering Committee who will provide mentoring and oversight and engage (for identification of early-stage investigators, for review of the pilot awards, and expert mentorship) the community of researchers across the multi-institutional consortium encompassing Brow University (Center of the Biology of Aging, Brown and Lifespan Cancer Centers), the Warren Alpert Medical School, the clinical experts from the Lifespan healthcare/Rhode Island Hospital and from Care new England. By establishing a multidisciplinary scientific infrastructure providing access to state-of- the-art instrumentation and technologies, as well as rigorous mentorship, advising, review and outcome guidance, the Phase 3 SCA COBRE Pilot Grant Program will contribute to expansion and transformation the biomedical and educational landscape within Rhode Island, creating a premier national center for research on stem cell, aging, and regenerative medicine. We will evaluate the program using outcome measures that include number and quality of submissions (measured by review scores), mentor and investigator evaluations and diversity of applicants and success in securing extramural awards.