Pilot Project Program

摘要 试点项目计划的目标是支持生物医学研究中心的使命 达特茅斯的分子流行病学卓越中心（COBRE），以推进变革性发现 以减轻人类疾病的负担，并培养该领域的未来领导者。到目前为止，试点项目 该计划支持了15个试点项目，这些项目由早期、中期和高级调查人员领导， 为中心的以下主题做出了贡献：i）应用新的科学发现和技术来解决重大问题 健康问题，ii）确定疾病发病机制的早期指标，iii）探索 疾病的病因和进展，包括与健康不平等有关的疾病。试点 项目领导人发表了326篇同行评审的手稿，并获得了52笔校外赠款， 主要调查员，总计8580万美元。在我们第一和第二阶段工作取得成功的基础上， 我们建议，透过吸纳外界顾问及以往试验计划得奖者的意见， 第三阶段的试点项目计划，以加速科学发现和校外的职业轨迹 支持分子流行病学领域有才华的科学家。申请人将通过多个 媒体和渠道的三个资金机会：1）新的和早期阶段的研究项目，以加快 职业发展和研究独立性; 2）多PI项目，促进多学科团队 科学导致更大的计划和中心赠款;和3）多机构项目，加强 与合作的IDEA国家合作。我们将鼓励来自代表性不足群体的申请人， 促进解决弱势群体健康问题的研究，将生物性别视为潜在的 疾病风险的调节剂，并受益于该中心最先进的生物储存库和生物标本 核心资源设施。我们还将考虑到一个快速通道机制的时间敏感，高风险，高回报 应用.将要求一份意向书，以筛选资格，并允许申请前的指导。 申请将由审查小组使用NIH研究部分的标准和流程进行排名， 通过外部咨询委员会的资助建议，然后提交给NIH进行最终评估。 批准获奖后的指导和整体职业发展服务将根据试点领导者的需求量身定制。 目标、科学重点和职业阶段。机会将响应成员调查和指导 指导委员会和咨询委员会。因此，我们的战略将为试点领导者提供必要的 初步数据，指导和培训，以竞争多种赠款机制，并提高影响力 分子流行病学的独立和合作研究项目。

ABSTRACT The goal of the Pilot Project Program is to support the mission of the Centers of Biomedical Research Excellence (COBRE) Center for Molecular Epidemiology at Dartmouth, to advance transformative discoveries to reduce the burden of human disease and develop future leaders in the field. To date, the Pilot Project Program has supported 15 pilot projects led by early-stage, mid-career, and senior investigators that have contributed to the Center themes of i) applying new scientific discoveries and technologies to address major health concerns, ii) identifying early indicators of disease pathogenesis, and iii) exploring common pathways of disease etiology and progression in human populations, including those related to health inequities. Pilot Project Leaders have published 326 peer-reviewed manuscripts and received 52 extramural grants as Principal Investigators, totaling $85.8 million dollars. Building on the success of our work in Phases I and II, and by incorporating feedback from external advisors and previous pilot awardees, we propose to enhance the Pilot Project Program in Phase III to accelerate the career trajectories to scientific discovery and extramural support of talented scientists in the field of molecular epidemiology. Applicants will be solicited through multiple media and channels for three funding opportunities: 1) new and early-stage investigator projects to expedite career development and research independence; 2) multi-PI projects that promote multi-disciplinary team science leading to larger program and center grants; and 3) multi-institution projects that strengthen collaborations with partnering IDeA states. We will encourage applicants from underrepresented groups and facilitate research that addresses the health of vulnerable populations, considers biological sex as potential modifier of disease risk, and benefits from the Center’s state-of-the-art Biorepository and Biospecimen Resource Facility Core. We also will allow for a fast-track mechanism of time-sensitive, high-risk, high-reward applications. A letter of intent will be requested to screen for eligibility and permit pre-application mentoring. Applications will be ranked by a review panel using the criteria and processes of NIH study sections, followed by funding recommendations by the External Advisory Committee prior to submission to the NIH for final approval. Post-award mentorship and holistic career development offerings will be tailored to the Pilot Leaders’ goals, scientific focus, and career stage. Opportunities will be responsive to member surveys and guidance from the Steering and Advisory Committees. Thus, our strategy will provide Pilot Leaders with the necessary preliminary data, mentorship, and training to compete for multiple grant mechanisms, and to grow impactful independent and collaborative research programs in molecular epidemiology.