High-Performance PET/CT Instrumentation

项目摘要/摘要 这项提议旨在升级约翰霍普金斯正电子发射装置的成像能力 层析成像(PET)中心配备新的高性能、人体尺度的PET/CT仪器。 PET是一种非侵入性的分子成像技术，可用于可视化和量化 体内的功能过程。各种各样的生物过程和疾病状态可能 通过选择合适的放射性药物进行研究。这种灵活性和范围 创造新的放射性药物来审问不同的目标意味着相同的扫描仪 系统可用于各种研究目的。宠物在世界各地做出了重大贡献 许多不同的领域，包括神经科学、肿瘤学、心脏病学和其他。建议的新 PET/CT仪器将专门用于研究，并将取代现有的两台仅使用PET的仪器 已达到使用寿命的扫描仪。高空间分辨率、高灵敏度和 出众的飞行时间能力以及与x射线CT的在线集成意味着新的 扫描仪将大大改进目前可用的技术。这一增强的技术 性能将转化为更高的图像质量和量化参数， 准确性和更高的统计可靠性。目前的建议旨在利用 约翰霍普金斯大学现有的基础设施和环境。PET中心设备齐全 放射化学设备和在放射性药物开发、PET成像方面的丰富经验 方法论和定量数据分析。还有一大批由国家卫生研究院资助的调查人员 他们已经为旧的、不可靠的PET系统和有限的PET/CT机会而苦苦挣扎了一段时间。 更多的访问和更好的成像能力将提高数据收集和 加快大型数据集的积累。此外，的新功能和灵活性 拟议的扫描仪将扩大可能的研究范围，鼓励新的研究 PET在整个研究界的应用和更广泛的采用。该项目将支持 并加强NIH资助的神经科学、肿瘤学、心脏病学和其他领域的研究 包括感染。PET的敏感度及其对分子靶向的独特能力 体内的过程将推动我们对疾病的理解的进步。此外，数量上的 PET的能力可以帮助开发和评估新的治疗方案，提供客观的 早期治疗有效性的证据。因此，当前的提案具有 有潜力推进转化性研究，为改善公共卫生作出贡献。

Project Summary / Abstract This proposal aims to upgrade the imaging capability of the Johns Hopkins Positron Emission Tomography (PET) Center with new high-performance, human-scale PET/CT instrumentation. PET is a non-invasive, molecular imaging technique that can be used to visualize and quantify functional processes in-vivo. A wide variety of biological processes and disease states can be studied by selection of an appropriate radiopharmaceutical. This flexibility and the scope for creating new radiopharmaceuticals to interrogate different targets means that the same scanner system can be used for a variety of research purposes. PET has made major contributions across many different fields including neuroscience, oncology, cardiology and others. The proposed new PET/CT instrument will be used exclusively for research and will replace two existing PET-only scanners that have reached their end-of-life. High spatial resolution, high sensitivity and outstanding time-of-flight capability, as well as in-line integration with x-ray CT mean the new scanner will greatly improve upon currently available technology. This enhanced technical performance will translate to higher image quality and quantitative parameters with greater accuracy and improved statistical reliability. The current proposal aims to take advantage of the existing infrastructure and environment at Johns Hopkins. The PET Center has well-equipped radiochemistry facilities and much experience in radiopharmaceutical development, PET imaging methodology and quantitative data analysis. There is also a large pool of NIH funded investigators who have struggled for some time with old, unreliable PET systems and limited access to PET/CT. Greater access and improved imaging capability will enhance the quality of data collection and accelerate accrual of large data sets. Furthermore, the new capabilities and flexibility of the proposed scanner will broaden the range of studies that are possible, encouraging new research applications and wider adoption of PET across the research community. This project will support and enhance NIH-funded research in neurosciences, oncology, cardiology and other areas including infection. The exquisite sensitivity of PET and its unique capability to target molecular processes in-vivo will drive advances in our understanding of disease. In addition, the quantitative capability of PET can help develop and assess new treatment options, providing objective evidence for treatment effectiveness at an early time point. As such the current proposal has the potential to advance translational research and contribute towards improved public health.