Console Upgrade for 4.7T PET-MRI Preclinical Scanner

项目摘要 申请资金用于升级现有的4.7Tesla Bruker PET-MRI控制台。拟议 仪器将是促进新型PET和MR分子成像发展的关键部件 造影剂和用于脑结构和神经通路连接的扩散MRI研究。的PET-MRI scanner为NIH资助的大型用户社区提供服务，涵盖各种生物医学学科 包括纤维化、癌症、心脏病、基因表达以及脑结构和功能研究。我们目前 为MGH/哈佛/麻省理工学院系统内以及大波士顿/剑桥周围的用户提供服务 地区 要求的MRI控制台升级将取代旧的Avance III Bruker控制台，该控制台已接近年底。 有用的寿命。从2024年开始，布鲁克Biospin将不再为Avance III主机提供支持或服务。由于 到MRI控制台的时代，我们在过去几年中发生了许多设备故障， 造成了严重的扫描仪停机时间。今后，此类设备故障将难以解决，因为 布鲁克将不再储存备件或维修此类旧控制台。请求的控制台升级将 因此，使我们能够继续服务于大型当地NIH资助的用户社区，并提供重要的分子生物学服务。 成像和脑结构成像能力，以迅速扩大的用户群与分子和脑 成像兴趣。 特别是，拟议的仪器将允许与PET和MRI集成PET-MRI工作流程 在同一软件环境中采集的数据，无干扰图像重建和配准。在 此外，改进的3D动态匀场、基于EPI的扩散序列和梯度线圈性能 将大大增强脑弥散MRI研究。需要MR-PET的项目包括开发 磁共振成像（MRI）和正电子发射断层扫描（PET）造影剂用于分子 肝纤维化、心脏纤维化、肺纤维化、转移性乳腺癌、胃癌 胰腺癌、炎性疾病、亨廷顿病和基因的表观遗传调控 表情需要增强磁共振成像能力的项目包括高分辨率的大脑研究 神经组织显微结构，脑神经血管耦合和神经递质受体的多模式研究 溶瘤细胞的运输、心脏纤维化成像和化学交换饱和转移（CEST）MRI研究 病毒疗法

Project Summary Funding is requested for an upgrade of an existing 4.7 Tesla Bruker PET-MRI console. The proposed instrument will be a crucial component in facilitating the development of novel PET and MR molecular imaging contrast agents and for diffusion MRI studies of brain structure and neural pathway connectivity. The PET-MRI scanner serves a large NIH-funded user community encompassing a wide variety of biomedical disciplines including fibrosis, cancer, cardialogy, gene expression, and brain structure and function studies. We currently serve users both within the MGH/Harvard/MIT system as well as from around the greater Boston/Cambridge region. The requested MRI console upgrade will replace an old Avance III Bruker console that is nearing the end of its usefull lifetime. Starting in 2024 Bruker Biospin will no longer support or service the Avance III console. Due to the age of the MRI console, we have had numerous equipment failures over the last few years which have caused significant scanner downtime. In the future, such equipment failures will be difficult to address since Bruker will no longer stock spare parts or service such old consoles. The requested console upgrade would therefore allow us to continue to serve the large local NIH-funded user community and offer important molecular imaging and brain structural imaging capabilities to the rapidly expanding user base with molecular and brain imaging interests. In particular, the proposed instrument would allow for integrated PET-MRI workflow with both PET and MRI data acquired in the same software environment with seemless image reconstruction and registration. In addition, the improved 3D dynamic shimming, EPI based diffusion sequences, and gradient coil performance will greatly enhance the brain diffusion MRI studies. Projects requiring MR-PET include the development of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) contrast agents for molecular imaging of liver fibrogenesis, cardiac fibrosis, pulmnary fibrosis, metastatic breast cancer, gastric cancer, pancreatic adenocarcinoma, inflammatory diseases, Huntington’s Disease, and epigenetic regulation of gene expression. Projects requiring the enhanced MR imaging capabilities include high resolution studies of brain neural tissue microstructure, multimodal studies of brain neurovacular coupling and neurotransmitter receptor trafficking, cardiac fibrosis imaging, and Chemical Exchange Saturation Transfer (CEST) MRI studies of oncolytic virotherapy.