Evaluation of an OMV-adjuvanted Chimeritrope Vaccine against Lyme Disease
Evaluation of an OMV-adjuvanted Chimeritrope Vaccine against Lyme Disease
批准号:
10672571
负责人:
LISA MORICI
金额:
$127.5万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-30 至 2023-09-29
关键词:
AdjuvantAntigensAttenuatedBiteBorrelia burgdorferiBurkholderiaContractorDoseEtiologyEvaluationFormulationHumanIxodesLipid ALyme DiseaseLyme Disease VaccinesMembraneMusPreparationResearchSafetyScheduleTestingVaccine AdjuvantVaccinesVesicleefficacy evaluationefficacy studyimmunogenicitynonhuman primatepreventscreeningunvaccinated
中文摘要
承包商正在开发伯克霍尔德氏菌衍生的外膜囊泡(omv),含有自然减毒的脂质a,作为疫苗佐剂。这项研究将在预防人类莱姆病的疫苗的背景下开发佐剂。伯氏疏螺旋体是莱姆病的病原,莱姆病通过蜱虫叮咬传播。目前还没有批准的预防人类莱姆病的疫苗。
英文摘要
The Contractor is developing Burkholderia-derived outer membrane vesicles (OMVs), containing a naturally-attenuated lipid A, as a vaccine adjuvant. This research will develop the adjuvant within the context of a vaccine to prevent Lyme disease in humans. Borrelia burgdorferi is the etiologic agent of Lyme disease, which is transmitted by the bite of Ixodes ticks. There are no currently approved vaccines that prevent Lyme disease in humans.
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会议论文
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