Overture: A Multi-Scale Data Platform for Cancer Genomics Research

项目摘要/摘要 Overture是一组模块化的开源软件组件，旨在管理 大数据基因组项目既容易又更具成本效益。序曲系统促进公平数据 通过克服存储、管理、探索和管理方面的主要障碍来共享癌症基因组数据集 分发庞大的基因组规模的数据集。 在这个拟议的项目中，我们将实施交钥匙序曲数据管理系统(DMS)，以提供 在整个数据生命周期中管理癌症基因组数据的完整解决方案，并继续降低 癌症信息学领域研究人员面临的技术障碍。以扩展功能和 Overture DMS的潜力，我们将建立与第三方集成的新软件框架 可视化应用程序，以及与分析平台的数据交换。这一框架将使 社区将继续为特定的研究兴趣开发非常有价值的可视化应用程序 和数据类型，并将它们作为“应用程序”与Overture DMS集成。 在接下来的五年里，我们将：(1)将Overture组件的核心集合组合成一个可扩展的DMS 安装捆绑包，以促进一系列小规模到联合体规模的数据集的本地和云部署； (2)通过一种新颖的软件数据集成，使用第三方可视化和分析工具扩展DMS 框架；(3)通过实施全球基因组学与健康联盟加强数据访问控制 (GA4GH)护照和数据使用本体标准；(3)在癌症数据集中启用联合搜索 跨越不同的序曲平台；以及(4)改善外联和社区资源，以满足 生物信息学家、数据生产者和管理者、数据科学家和临床研究人员。序曲DMS 将是从研究人员那里消除大规模数据管理的复杂性的宝贵资源， 通过增加数据共享和发现来促进科学研究。

Project Summary/Abstract Overture is a collection of modular, open-source software components designed to make the management of big-data genomic projects both easy and more cost effective. The Overture system promotes FAIR data sharing of cancer genomic datasets by overcoming the major obstacles in storing, managing, exploring, and distributing massive genome-scale datasets. In this proposed project, we will implement a turnkey Overture Data Management System (DMS) to provide a complete solution to manage cancer genomic data throughout the data life cycle, and to continue lowering the technical barriers faced by researchers in the cancer informatics community. To extend the capabilities and potential of the Overture DMS, we will establish a new software framework for integration with third-party visualization applications, and for data exchange with analysis platforms. This framework will empower the community to continue developing extremely valuable visualization applications for specific research interests and datatypes, and to contribute them as “apps” to be integrated with the Overture DMS. Over the next five years, we will: (1) combine the core set of Overture components into a scalable DMS installation bundle to promote both local and cloud deployment for a range of small to consortia-scale datasets; (2) extend the DMS with third-party visualization and analysis tools through a novel software data integration framework; (3) enhance data access controls by implementing Global Alliance for Genomics and Health (GA4GH) Passport and Data Use Ontology standards; (3) enable federated searching within cancer datasets across different Overture platforms; and (4) improve outreach and community resources to meet the needs of bioinformaticians, data producers and managers, data scientists, and clinical researchers. The Overture DMS will be a valuable resource for removing complications of large-scale data management from researchers, allowing the advancement of scientific research by increasing data sharing and discovery.