Career Enhancement Core

项目摘要 布里格姆/哈佛生殖压力和神经调节中心的总体目标是 衰老健康结果是研究应激及其神经机制在生殖衰老中的作用 健康结果使老年妇女易患心血管疾病和痴呆症， 促进跨学科和翻译妇女健康和性别差异研究的增长。在这 在框架内，拟议的职业提升核心（CEC）将负责跨中心的整合 以及哈佛大学范围内的专业知识，为培养下一代提供丰富的研究和学习环境 研究人员在女性健康和性别差异的压力，睡眠，认知能力下降，心脏代谢， 疾病和神经调节研究。中央选举委员会处于独特的地位，可以利用强大的现有机构 项目和基础设施，以及开发跨学科的培训和指导计划。的 CEC的具体目标是：1）资助尖端的SCORE学者和试点项目，以有前途的早期- 职业调查员或已建立的调查员谁是获得新的技能，压力，神经调节， 睡眠，以促进性/性别和妇女的健康研究在生殖老龄化的健康结果有关， 心血管疾病和痴呆症的绝经后妇女; 2）培训CEC参与者在一个强大的 教育计划在性别差异的研究方法，透明度和严谨性，以及支持旅游 交流奖学金，以促进学习和与国家SCORE研究网络的合作;以及3） 将这些教育项目和研究方法的知识传播到当地和更广泛的地方 通过网络研讨会，出版物和在线教育论坛，全国社区。实现这些目标不会 这不仅推进了SCORE的使命，而且还将促进新的调查人员队伍的发展 在外地CEC将与所有Brigham/哈佛SCORE项目、SRC和LAC密切合作， 在妇女健康、睡眠医学、神经科学、压力科学等方面建立强大的现有研究基础设施， 心脏代谢疾病，以满足参与者的职业提升需求。此外，CEC将建立一个 为布里格姆/哈佛社区和更大的SCORE社区提供强大的教育资源。

PROJECT SUMMARY The overarching goal of the proposed Brigham/Harvard Center for Stress and Neural Regulation of Reproductive Aging Health Outcomes is to investigate the role of stress and its neural mechanisms in reproductive aging health outcomes that confer susceptibility to cardiovascular disease and dementia in aging women, and to catalyze growth of interdisciplinary and translational women’s health and sex-differences research. Within this framework, the proposed Career Enhancement Core (CEC) will be responsible for the integration of cross-Center and Harvard-wide expertise to provide a rich research and learning environment for training the next generation of investigators in women’s health and sex differences in stress, sleep, cognitive decline, cardiometabolic disease and neural regulation research. The CEC is uniquely placed to leverage strong existing institutional programs and infrastructure in addition to developing an interdisciplinary training and mentorship program. The specific aims of the CEC are: 1) To fund cutting-edge SCORE Scholars and Pilot Projects to promising early- career investigators or established investigators who are gaining new skills in stress, neural regulation, and sleep, to foster sex/gender and women’s health research in reproductive aging health outcomes relevant to cardiovascular disease and dementia in postmenopausal women; 2) To train CEC participants in a robust educational program in sex-differences research methods, transparency, and rigor, as well as support Travel Exchange Fellowships to foster learning and collaboration with the national SCORE research network; and 3) To disseminate knowledge from these educational programs and research methods to the local and wider national community through webinars, publications, and online educational forums. Achieving these aims will not only advance the mission of our SCORE but will also promote the development of a new cadre of investigators in the field. The CEC will work closely with all the Brigham/Harvard SCORE Projects, SRC, and LAC to leverage robust existing research infrastructure in women’s health, sleep medicine, neuroscience, stress science, and cardiometabolic disease to meet career enhancement needs for participants. Additionally, the CEC will build a robust educational resource for the Brigham/Harvard community and the larger SCORE community.