NRSA Training Core

联系PD/PI：Kern，Philip A.NRSA-Training-001(003) 项目摘要-TL1培训计划 肯塔基大学(英国)临床和翻译科学中心(CCTS)建议维持 并加强目前的博士后和博士后TL1课程，目前正处于国家 卫生研究院(NIH)的支持。通过提供融合学员的多学科培训计划 TL1项目跨越不同的领域，提供严谨而扎实的翻译研究教育 有效地培训临床医生和科学家，使他们成为临床和翻译领域的领导者 科学。英国TL1计划的特点是在强大的生产力队列中进行大量合作 调查人员、合格申请者的人才库、坚实的基础设施和强有力的机构支持。这个 该计划利用了英国六所医疗保健学院(医学、护理、 药学、公共卫生、健康科学、牙科)和主校区的重点学科(如 工程、社会工作、生物学、心理学、教育学)培养广泛领域的学者 对于成功的临床和转化性研究(CTR)来说是必要的。该计划支持职业发展 具有研究兴趣的学者的寿命跨度(从产前到老年人)和 临床和翻译科学，包括翻译、临床、社区/政策研究和CTR 方法/过程(例如，生物医学信息学)，侧重于广泛的健康主题。TL1学员 正在通过出版的作品对科学做出重要贡献，所有该项目的毕业生都是 积极参与CTR。这一计划和其他由CCTS赞助的努力正在吸引未得到充分服务的学生 在以肯塔基州和阿巴拉契亚中部地区健康差距为重点的项目中。我们要求 美国国立卫生研究院为八名TL1学者提供了新的支持。拟议方案的基础将继续是 在经验丰富的导师的指导下，在多学科团队中的实际研究经验 提供教育和培训，如证书、硕士和博士学位，以确保事业成功 这些未来的CTR领导者的发展。基于临床研究的学者能力评估 评估表，用于指导新课程提供与理论，谁有高 对自己技能的信心更有可能在CTR追求职业生涯。英国CCTS开发的管道项目 面向专业和研究生，包括支持健康股票研究人员的新举措 和来自代表性不足群体的受训人员，将确保有一批强大的候选人参加 TL1程序。总而言之，TL1计划旨在加快未来领导者在 翻译科学工作者将准备好应对当今复杂的研究挑战和 是人类健康进步的先锋。 项目摘要/摘要页1236 联系PD/PI：Kern，Philip A.NRSA-Training-001(003) 参考书目及引用文献 Fowler BJ，Gelfand BD，Kim Y，Kerur N，Tarallo V，Hirano Y，Amarnath S，Fowler DH，Radwan M，Young 首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容 T，Yasuma R，Wright C和Ambati J.核苷逆转录酶抑制剂具有内在的抗 炎症活动。科学346：1000-3,2014。PMCID：PMC4274127。 2.发明人Ambati J、Fowler B和Ambati K；治疗视网膜退化的组合物和方法 20180044327号专利。2018年2月15日2018年2月15日。 3.Sherwood AR、Johnson MB、Delgado-Escueta AV和Gentry女士拉福拉病和 拉福林葡聚糖磷酸酶活性。临床生物化学46：1869-76,2013。PMCID：PMC3864130。 4.发明人Albuquque R、Vora P和Bell N；专利条款：评估系统和方法 利用彩色放大专利13177N/2191US无创检测脉络膜血流 5.美国国立卫生研究院的CTSA计划：推进临床和翻译研究的机会。可在以下位置获得 Http://www.nationalacademies.org/hmd/Activities/Research/CTSAreview.aspx.2019年访问 6.Brown CA、酱Y、Smith CD和Gold BT。年龄和阿尔茨海默病的病理破坏了默认模式网络 通过白质微结构的改变而不是高信号来发挥作用。皮质104：58-74,2018。 PMCID：PMC6008234。 7.Gupta VA、Sousa M、Kraitman N、Annabathula R、Vsevolozhskaya O、Leung Sw和Sorrell VL.冠状动脉 动脉钙化可预测败血症后的心血管并发症。J Crit Care 44：261-6,2018。 8.Areephanthu CJ，Bole R，Stratton T，Kelly Th，Starnes CP和Sawaya BP。专业学生的影响 医学教育和学术医学职业道路指导研究奖学金。临床翻译科学 2015年8：479-83。PMCID：PMC4626384。 9.班杜拉A.自我效能感：走向行为改变的统一理论。《精神病学》第84期：191-215,1977年。 10.Mullikin EA、Bakken LL和Betz NE。评估内科科学家的研究自我效能感 临床研究评价表。职业评估杂志15：367-87,2007。 11.罗宾逊GF、Switzer GE、Cohen Ed、Primack BA、Kapoor WN、Seltzer DL、Bakken LL和Rubio DM。一个 临床研究评估表的简写版本：CRAI-12。ACAD Med 88：1340-5,2013。 PMCID：PMC3758379。 12、普塞克·S、克努森·B和泽瓦特·J.翻译科学学员的个性化培训路径： 建立在整个翻译科学领域的知识、技能和能力的框架上。J临床 翻译科学2020(印刷中)。 引用文献第1237页

Contact PD/PI: Kern, Philip A. NRSA-Training-001 (003) PROJECT SUMMARY – TL1 TRAINING PROGRAM The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) proposes to sustain and enhance the current pre-doctoral and post-doctoral TL1 program, currently in its ninth year of National Institutes of Health (NIH) support. By providing a multidisciplinary training program that integrates trainees across diverse fields and offers rigorous and solid translational research education, the TL1 program has effectively prepared clinicians- and scientists-in-training for careers as leaders in clinical and translational science. The UK TL1 program features substantial collaborations across a robust cohort of productive investigators, a talented pool of qualified applicants, solid infrastructure and strong institutional support. The program takes advantage of the physical juxtaposition of UK’s six health care colleges (Medicine, Nursing, Pharmacy, Public Health, Health Sciences, Dentistry) and key disciplines on the main campus (e.g. Engineering, Social Work, Biology, Psychology, Education) to train scholars across wide-ranging fields necessary for successful clinical and translational research (CTR). The program supports career development of scholars with research interests that cross the lifespan (prenatal through elderly) and the full spectrum of clinical and translational science, including translational, clinical, community/policy studies and CTR methods/processes (e.g., biomedical informatics) focusing on a broad array of health topics. The TL1 trainees are making important contributions to science through published work, and all of the program graduates are actively engaged in CTR. This program and other CCTS-sponsored efforts are engaging underserved students in projects focused on health disparities of Kentucky and the Central Appalachian area. We are requesting renewed NIH support for eight TL1 scholars. The foundation of the proposed program will continue to be practical research experiences within multidisciplinary teams guided by experienced mentors along with educational and training offerings, such as certificate, Master’s and PhD degrees, to ensure successful career development of these future CTR leaders. Scholar competency assessments, based on the Clinical Research Appraisal Inventory, serve to guide new program offerings with the theory that trainees who have high confidence in their skills are more likely to pursue a career in CTR. UK CCTS-developed pipeline programs targeting professional and graduate students, including new initiatives to support health equities researchers and trainees from under-represented groups, will ensure the availability of a strong pool of candidates for the TL1 program. In sum, the TL1 program is designed to accelerate career development of future leaders in the translational science workforce who will be prepared to address today’s complex research challenges and spearhead advances in human health. Project Summary/Abstract Page 1236 Contact PD/PI: Kern, Philip A. NRSA-Training-001 (003) BIBLIOGRAPHY AND REFERENCES CITED 1. Fowler BJ, Gelfand BD, Kim Y, Kerur N, Tarallo V, Hirano Y, Amarnath S, Fowler DH, Radwan M, Young MT, Pittman K, Kubes P, Agarwal HK, Parang K, Hinton DR, Bastos-Carvalho A, Li S, Yasuma T, Mizutani T, Yasuma R, Wright C and Ambati J. Nucleoside reverse transcriptase inhibitors possess intrinsic anti- inflammatory activity. Science 346:1000-3, 2014. PMCID:PMC4274127. 2. Ambati J, Fowler B and Ambati K, inventors; Compositions and Methods for Treating Retinal Degradation patent 20180044327. 2018 Feb 15, 2018. 3. Sherwood AR, Johnson MB, Delgado-Escueta AV and Gentry MS. A bioassay for Lafora disease and laforin glucan phosphatase activity. Clin Biochem 46:1869-76, 2013. PMCID:PMC3864130. 4. Albuquerque R, Vora P and Bell N, inventors; Provision Patent: System and Method for Assessment of Choroidal Blood Flow Noninvasively Using Color Amplification patent 13177N/2191US 5. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research. Available at http://www.nationalacademies.org/hmd/Activities/Research/CTSAreview.aspx. Accessed 2019 6. Brown CA, Jiang Y, Smith CD and Gold BT. Age and Alzheimer's pathology disrupt default mode network functioning via alterations in white matter microstructure but not hyperintensities. Cortex 104:58-74, 2018. PMCID:PMC6008234. 7. Gupta VA, Sousa M, Kraitman N, Annabathula R, Vsevolozhskaya O, Leung SW and Sorrell VL. Coronary artery calcification predicts cardiovascular complications after sepsis. J Crit Care 44:261-6, 2018. 8. Areephanthu CJ, Bole R, Stratton T, Kelly TH, Starnes CP and Sawaya BP. Impact of Professional Student Mentored Research Fellowship on Medical Education and Academic Medicine Career Path. Clin Transl Sci 8:479-83, 2015. PMCID:PMC4626384. 9. Bandura A. Self-efficacy: toward a unifying theory of behavioral change. Psychol Rev 84:191-215, 1977. 10. Mullikin EA, Bakken LL and Betz NE. Assessing Research Self-Efficacy in Physician-Scientists: The Clinical Research APPraisal Inventory. Journal of Career Assessment 15:367-87, 2007. 11. Robinson GF, Switzer GE, Cohen ED, Primack BA, Kapoor WN, Seltzer DL, Bakken LL and Rubio DM. A shortened version of the Clinical Research Appraisal Inventory: CRAI-12. Acad Med 88:1340-5, 2013. PMCID:PMC3758379. 12. Pusek S, Knudson B and Tsevat J. Personalized training pathways for translational science trainees: building on a framework of knowledge, skills and abilities across the translational science spectrum. J Clin Transl Sci 2020 (in press). References Cited Page 1237