Developmental Research Program

项目总结(发展研究计划) 发展研究方案的具体目标是： 1.宣传表观遗传疗法领域试点转化研究的资金可获得性 治疗癌症。 2.通过这一机制确定具有重大发展和改进潜力的创新项目 癌症的表观遗传疗法。 3.鼓励与孢子内外的科学家开展项目合作， 具体地说，范安德尔研究所--对抗癌症表观遗传学梦想团队(VAI-SU2C)。 4.加强孢子领导人与VAI-SU2C调查人员之间的沟通，以鼓励 开发癌症的创新表观遗传学疗法。 5.确保计划的灵活性，以便有希望的发展项目可以：1)为 第二年；2)鼓励申请同行评审资金(即R01)；或3)扩大至满 孢子项目。 该计划的结构和流程是以长期而成功的开发为蓝本的 MDACC白血病孢子内的研究计划和VAI-SU2C表观遗传学的成功 在征集、审查、授予和监督发展研究项目提案方面的梦之队。至 为了实现我们的目标，我们将建立1)通过同行审查机制进行遴选和资助的具体标准， 2)密切监测孢子领导人和项目之间的合作机制 获奖者提高翻译研究目标的质量。

PROJECT SUMMARY (Developmental Research Program) The specific objectives of the Developmental Research Program are to: 1. Publicize the availability of funds for pilot translational research studies in the field of Epigenetic Therapy for cancers. 2. Identify through this mechanism innovative projects with significant potential for developing and improving Epigenetic Therapies for cancers. 3. Encourage collaborations of projects with scientists within the SPORE and outside the SPORE, specifically the Van Andel Institute-Stand Up To Cancer Epigenetics Dream Team (VAI-SU2C). 4. Enhance the communication between the SPORE leaders and VAI-SU2C Investigators to encourage the development of innovative epigenetics therapies for cancer. 5. Ensure program flexibility so that developmental projects that show promise can be: 1) funded for a second year; 2) encouraged to apply for peer-reviewed funding (i.e. R01); or 3) expanded to become full SPORE projects. The structure and processes of this program are modeled after a long-standing and successful Developmental Research Program within the MDACC Leukemia SPORE, and on the success of the VAI-SU2C Epigenetics Dream Team in soliciting, reviewing, awarding and monitoring developmental research project proposals. To achieve our aims, we will establish 1) specific criteria for selection and funding through a peer review mechanism, and 2) mechanisms for close monitoring of, and collaboration between the SPORE leaders and program awardees to enhance the quality of the translational research goals.