Biostats Core (TBD)

项目摘要-生物统计学和生物信息学核心3 P01申请“肿瘤的分子靶向放射性核素治疗”的总体目标 免疫调节和增强免疫治疗反应”是为了发展一个广泛的机制理解 分子靶向放射性核素治疗的免疫调节能力，作为下一代 免疫治疗方法，以改善免疫“热”和“冷”肿瘤的治疗。的 生物统计学和生物信息学核心（BBC）的总体目标是促进临床前研究的卓越性， 在此P01申请中提出的翻译研究，通过提供专门和出色的咨询， 为P01提供生物统计学、生物信息学和研究数据管理方面的协作支持和专业知识 项目1-4，行政核心项目、核心项目1（放射性核素生产和放射化学核心项目）和核心项目2 （高级成像和剂量测定核心），并根据需要。 生物统计部分将为所有四个项目和两个核心项目提供支助。生物统计学小组 它的力量来自生物统计学系与P01研究人员多年的合作。生物统计 对项目1和核心2（高级成像和剂量测定核心）的支持将是描述性和探索性的， 性质，并涉及统计建模和剂量学研究中的估计。项目2的生物统计支持- 4将涉及统计建模和推断，并将在性质上进行比较。 生物信息学部分拟为项目2-4提供支持。生物信息学团队绘制了 来自生物信息学教师的力量，他们与P01研究人员积极合作。更具体地说， 它将通过1）T细胞受体序列数据，2）RNAseq 来自小鼠的选择性肿瘤的数据，与对照肿瘤相比，其显示肿瘤的治愈性根除 以及接受次优治疗导致免疫治疗逃逸的肿瘤，以及3）单细胞RNAseq 数据 为了支持行政核心和P01整体，BBC将使用 关系数据库管理系统，将作为所有项目的记录数据库， 这是P01英国广播公司将使用该数据库为研究数据管理提供支持，该数据库将保存所有 从P01的项目和核心生成的数据，并作为中央数据中心，所有 生物统计学和生物信息学分析将作为基础。

PROJECT SUMMARY – BIOSTATISTICS AND BIOINFORMATICS CORE 3 The overarching goal of the P01 application “Molecular Targeted Radionuclide Therapy for Tumor Immunomodulation and Enhancing Immunotherapy Response” is to develop a broad mechanistic understanding of the immunomodulatory capacity of molecular targeted radionuclide therapy as part of the next generation of immunotherapy approaches to improve the treatment of immunologically “hot” and “cold” tumors. The overarching goal of the Biostatistics and Bioinformatics Core (BBC) is to promote excellence in pre-clinical translation research proposed in this P01 application by providing dedicated and outstanding consultation and collaborative support and expertise in biostatistics, bioinformatics and research data management for the P01 Projects 1-4, Administrative Core, Core 1 (Radionuclide Production and Radiochemistry Core), and Core 2 (Advanced Imaging and Dosimetry Core), and as needed. The biostatistics component will provide support for all four projects and two cores. The biostatistics team draws its strength from biostatistics faculty with many years of collaboration with the P01 investigators. Biostatistics support for Project 1 and Core 2 (Advanced Imaging and Dosimetry Core) will be descriptive and exploratory in nature and involve statistical modeling and estimation in dosimetry studies. Biostatistics support for Projects 2- 4 will involve statistical modeling and inference and will be comparative in nature. The bioinformatics component proposes to provide support for Projects 2-4. The bioinformatics team draws its strength from bioinformatics faculty who have active collaboration with the P01 investigators. More specifically, it will provide bioinformatics support and analysis expertise with 1) T cell receptor sequence data, 2) RNAseq data from selective tumors of mice that show curative eradication of tumors in comparison with control tumors and to tumors receiving sub-optimal therapy resulting in escape of immunotherapy, and 3) single cell RNAseq data. In supporting the Administrative Core and the P01 overall, the BBC will develop a P01-wide database using a relational database management system that will serve as the database of record for all projects and cores for this P01. The BBC will provide support in research data management using this database, which will hold all data generated from the Projects and Cores of the P01 and serve as the central data hub upon which all biostatistics and bioinformatics analyses will be based.