HIP fracture Accelerated surgical TreaTment And Care tracK-2 (HIP ATTACK-2) trial

摘要 拟议的试验名为髋关节攻击-2，旨在改善数千名患者的预后 髋部骨折并伴有急性心脏损伤的医院。急性心脏损伤的特征是 血清肌钙蛋白：这种心脏损伤通常是无症状的，但在高达20%的髋部骨折患者中可以发现 在手术前。这些患者的预后比没有心脏损伤的患者差得多(即24%对 90天死亡率分别为8%)。尽管这个问题很严重，但标准的医疗管理已经 在改善这些患者的预后方面进展甚微。髋关节攻击-2试验的目标是 通过将加速手术(&lt；6小时)与标准护理进行比较来确认先前的特别小组研究结果 在髋部骨折患者中，出现血清肌钙蛋白升高。这组多中心、平行组随机 对照试验将解决三个具体目标：1)确定加速手术是否降低了90天的风险 有急性心脏损伤的髋部骨折患者的死亡率，2)确定是否加速手术 增加患者在90天内能够独立行走10英尺的比例，3)以确定 加速手术改善了患者报告的生活质量，并减少了内科和外科并发症。

ABSTRACT The proposed trial, HIP ATTACK-2, seeks to improve the outcomes of thousands of patients who present to the hospital with a hip fracture and concomitant acute heart injury. Acute heart injury is characterized by an elevated serum troponin; this heart injury is often asymptomatic but can be identified in up to 20% of hip fracture patients prior to surgery. These patients have a much worse prognosis than patients with no heart injury (i.e., 24% versus 8% 90-day mortality, respectively). Despite the magnitude of this problem, standard medical management has made little progress in improving the outcomes of these patients. The objective of the HIP ATTACK-2 trial is to confirm the previous post-hoc subgroup findings by comparing accelerated surgery (<6 hours) to standard care in hip fracture patients presenting with elevated serum troponin. This multicenter, parallel group randomized controlled trial will address three specific aims: 1) to determine if accelerated surgery reduces the risk of 90-day mortality in hip fracture patients who also have an acute heart injury, 2) to determine if accelerated surgery increases the proportion of patients able to independently ambulate 10 feet at 90-days, 3) to determine if accelerated surgery improves patient-reported quality of life and decreases medical and surgical complications.