Characterizing brain dynamic biomarkers of fentanyl using intracranial and high-density electroencephalogram in humans

阿片类药物过量死亡仍然是美国的一个主要公共卫生问题。现在人们认识到，手术和 术后疼痛是阿片类药物持续使用和依赖的主要原因。管理不力 术中疼痛增加会导致术后疼痛增加，从而导致阿片类药物的增加。 使用、慢性疼痛、阿片依赖和阿片类药物滥用。在这个围手术期设置一个主要的挑战 病人要么昏迷(在手术室)，要么大量镇静(在麻醉后护理中 单位)，不能报告他们的疼痛程度。在这些情况下，麻醉师和护士只能猜测 他们对阿片类药物的需求，因为他们无法实时测量阿片类药物的效果。一个 实时测量阿片类药物的影响，如果存在的话，将允许麻醉师和护士 精确滴定阿片类药物，可显著改善术后疼痛管理和继发率 阿片类药物的使用、依赖和过量。在过去的两年里，我的实验室研发出了一种真正的- 阿片类药物的时间生物标志物，可用于阿片类药物和药物的更准确的滴定 发现应用程序。在这个项目中，我们打算研究这种生物标记物背后的机制。 并进一步发展翻译科学，以支持该生物标记物的临床应用。

Opioid overdose deaths remain a major public health problem in the US. It is now recognized that surgery and post-operative pain are major contributors to persistent opioid use and dependence. Inadequate management of intraoperative nociception can lead to increased post-operative pain, which can lead to increased opioid utilization, chronic pain, opioid dependence, and opioid abuse. In this perioperative setting a major challenge is that patients are either unconscious (in the operating room) or heavily sedated (in the post-anesthesia care unit) and cannot report their pain levels. In these scenarios, anesthesiologists and nurses can only guess the opioid requirements for their patients, as they have no means to measure opioid drug effects in real-time. A real-time measurement of opioid drug effects, if it existed, would allow anesthesiologists and nurses to precisely titrate opioids and could significantly improve post-operative pain management and subsequent rates of opioid utilization, dependence, and overdose. Over the past two years my laboratory has developed a real- time biomarker for opioid drugs that could be used to provide more precise titration of opioid drugs and for drug discovery applications. In this project we propose to investigate the mechanisms underlying this biomarker and develop further translational science to support clinical application of this biomarker.