Einstein's Nathan Shock Center of Excellence in Basic Biology of Aging

摘要 爱因斯坦·内森冲击中心的健康范围核心(HSC)是一种独特的资源 老年学家需要复杂的体内代谢表型研究和专门的手术， 包括异慢性异型共生。HSC将继续作为“黄金标准”分析评估的资源 衰老-新陈代谢相互作用，也是副生物手术和组织的来源。在比赛中的目标 下一个资助期将是：1)适应持续增长的异种生物需求以及稳定的 要求进行代谢研究；2)使用新建立的功能分析和相关服务，以提供 更全面地评估健康跨度，以及3)提供以下方面的技术支持和咨询 常规实施各种外科和活体方法中的老龄化研究和培训 由核心执行。 这个核心的具体目标是：1)提供专门的体内新陈代谢测量；2) 建议和协助进行健康跨度评估，并提供老年病理学资源；3)执行 分析全身能量平衡；4)为老龄啮齿动物提供专门的外科手术。5)至 提供可用于量化啮齿动物脂肪组织分布、肝脏和肌肉的成像方法 糖原和器官脂质。6)提供异慢性异种异种外科服务，并继续 有相关的组织和血浆库。7)积累和定义健康跨度的标准值 跨菌株，并确定它们与其他功能域、衰老过程中的虚弱和老年病理的关系。 HSC的活动是：1)通过提供独特和有价值的实验分析来提供服务，这些实验分析不是很高 可行的或容易获得的，例如专门的代谢分析、手术和老年病理学，2) 资源，作为正常衰老和异慢性异种共生组织的组织储存库 应要求提供小鼠和大鼠以及实验方案3)集中不同的电池 通过扩展核心功能进行功能分析和服务，以促进全面的健康范围 在单一地点进行评估，以及4)咨询和培训，向调查人员提供意见，寻求 协助设计或实施他们的研究，或需要在核心技术方面动手。 人员：1)主任(霍夫曼)处理所有请求，帮助制定实验计划，建立 确定优先顺序，监督数据收集，并与HSC工作人员合作编写最终报告。2) 主任与咨询委员会的主要人员和成员协商，以提供智力和/或 在具体项目上的技术专长和援助，3)HSC配备了两名全职有经验的工作人员 外科医生，一名受过健康跨度评估培训的高级科学家和技术员，以进行研究。 相关性：HSC拥有独特的能力，能够满足寻求高质量调查人员的要求 体内代谢、健康跨度分析、外科手术和特殊组织，以及老年病理学。

Summary The Health Span Core (HSC) of the Einstein Nathan Shock Center serves as a unique resource for geroscientists in need of sophisticated in vivo metabolic phenotyping studies, and specialized surgeries, including heterochronic parabiosis. The HSC will continue to be a resource for ‘gold standard’ assays to assess the aging-metabolism interplay as well as a resource for parabiotic surgeries and tissues. The goals during the next funding period will be to: 1) accommodate the continuously growing demand for parabiosis as well as steady requests for metabolic studies; 2) employ newly established functional assays and related services to provide a more comprehensive assessment of health span, and 3) provide technical support and consultation regarding implementation of aging studies and training in the various surgical and in vivo methodologies routinely performed by the Core. Specific Aims of this Core are: 1) To make available specialized in vivo measurements of metabolism; 2) To advise and assist in performing health span assessments and provide a geropathology resource; 3) To perform analyses of whole body energy balance; 4) To provide specialized surgical procedures in aging rodents. 5) To make available imaging modalities for quantification of rodent adipose tissue distribution, liver and muscle glycogen, and organ lipids. 6) To provide heterochronic parabiosis surgical services and continue to make available a related tissue and plasma repository. 7) Accumulate and define normative values for health span across strains, and determine their relation to other functional domains, frailty and geropathology in aging. Activities of the HSC are: 1) Service by providing unique and valuable experimental assays that are not highly feasible or readily accessible, such as specialized metabolic assays, surgeries and geropathology, 2) Resources, by serving as a tissue repository for both normal aging and heterochronic parabiosis tissue from mice and rats and experimental protocols made available upon request 3) Centralizing a diverse battery of functional assays and services via expansion of Core capabilities to facilitate comprehensive health span assessments at a single site, and 4) Consultation and training by providing input to investigators either seeking assistance in designing or implementing their study or in need of hands-on in Core technologies. Personnel: 1) The Director (Huffman) handles all requests, helps to formulate an experimental plan, establishes prioritization, provides oversight of data collection, and works with HSC staff to compile a final report. 2) The Director consults with key personnel and members of the advisory committee to provide intellectual and/or technical expertise and assistance on specific projects, 3) The HSC is staffed with two full-time experienced surgeons, a senior staff scientist and technician trained in health span assessment to carry out the studies. Relevance: The HSC uniquely harbors the ability to address requirements of Investigators seeking high quality in vivo metabolism, health span assays, surgeries and specialty tissues, and geropathology.