Neurobiological impact of acute digital media abstinence among drug using college students

项目总结 成瘾药物的使用在大学年龄的年轻人中非常普遍，并与物质使用的发展有关 在以后的生活中，疾病和其他负面的健康后果。因此，了解推动使用的因素是至关重要的公共健康 担忧。虽然先前的工作将使用与心理社会因素联系在一起，但对技术设备(例如移动设备)的依赖增加 手机、电脑、游戏机)带来了新的风险因素，不容忽视。随着数字媒体提供一种 持续源源不断的奖励刺激，过度使用可能会扰乱神经生物学和奖励处理 与药物使用有关的系统，在预防时会导致戒断症状。数字戒断症状可能 加剧对数字媒体的渴望，以及对其他奖励(如毒品)的渴望，进而导致上瘾风险增加 数字媒体和毒品使用。识别不适应技术使用的症状，这些症状可能会使年轻人容易患上 不断升级的毒品使用至关重要。拟议项目的主要目标是描述不同个体在 在一段时间的数字媒体戒断后，神经认知数字戒断症状和药物渴求，并评估 与数字和吸毒行为的联系。青少年吸毒者的脑功能和戒断症状 成人将在一段时间的数字媒体禁欲前后接受检查，在这段时间里，参与者将交出他们的 通宵使用手机，并同意不在屏幕前进行任何活动。具体地说，钢筋加工中的更改 急性数字戒断后的大脑功能和对药物和技术提示的响应性将被表征(目标 1)。与急性数字媒体有关的药物渴求和数字戒断症状(生理、情感、认知) 禁欲将被检查(AIM2)。最后，个体内容差异与数字媒体使用之间的关系 将检查病史、观察到的数字戒断症状和脑功能改变(Aim3)。建议的目标 将扩展PI在成瘾神经科学方面的现有经验，允许她研究成瘾的共病风险 数字和物质的使用，并在外周生理测量、高分辨率神经成像和 皮质下分割技术。

PROJECT SUMMARY Addictive drug use is highly prevalent among college-aged young adults and is linked to the development of substance use disorders and other negative health outcomes later in life. Thus, understanding factors driving use is a critical public health concern. While prior work has linked use to psycho-social factors, increased reliance on technological devices (e.g., mobile phones, computers, gaming consoles), has introduced new risk-factors that cannot be ignored. As digital media delivers a consistent stream of rewarding stimuli, heavy use has the potential to dysregulate neurobiological, reward processing systems implicated in drug use, and result in withdrawal symptoms when prevented. Digital withdrawal symptoms may intensify digital media craving, and craving for other rewards (e.g., drugs), in turn, leading to an increased risk for addictive digital media and drug use. Identifying symptoms of maladaptive technology use that may predispose young adults to escalating drug use is critical. The main objective of the proposed project is to characterize individual differences in neurocognitive digital withdrawal symptoms and drug craving, following a period of digital media abstinence, and assess associations with digital and drug use behaviors. Brain function, and withdrawal symptomology among drug using young adults will be examined before and after a period of digital media abstinence in which participants will surrender their mobile phone over-night and agree to not engage in any screen-time. Specifically, alterations in reinforcement processing brain function and responsivity to drug and technology cues, following acute digital abstinence, will be characterized (Aim 1). Drug craving and digital withdrawal symptoms (physiological, affective, cognitive) linked to acute digital media abstinence will be examined (Aim2). Finally, relations between individual differences in substance and digital media use history, observed digital withdrawal symptoms, and altered brain function will be examined (Aim3). The proposed aims will expand the PI’s existing experience in addiction neuroscience by allowing her to study comorbid risk for addictive digital and substance use and gain new training in, peripheral physiology measurement, high-resolution neuroimaging, and subcortical segmentation techniques.