FASEB SRC Calcium and Cell Function 2023

项目摘要 这是一份申请部分支持FASE B科学研究会议(SRC)关于钙和 细胞功能，将于2023年6月24日至6月29日在葡萄牙里斯本举行。这样做的目的是 会议的目的是激发讨论、播撒新想法并激发合作以加速新发现 在基础水平和翻译水平上的钙信号。钙被认为是生死的信号， 可以说是生物学中最普遍的第二信使之一，它在无数 生物过程，从心跳，血管张力，肌肉收缩，突触传递， 发育、基因表达、细胞迁移和免疫反应。钙信号处理中的缺陷 机械可导致大量严重疾病，包括神经障碍、免疫缺陷、 发育缺陷和心血管疾病(高血压、中风和心律失常)。因为. 这种功能和病理的极端多样性，致力于钙信号转导的研究人员倾向于呈现 他们在不同会议上的工作几乎没有重叠，尽管有许多共同的机制， 方法，以及对超越这些界限的钙信号的洞察。 为了解决这个问题，两年一度的FASEB SRC的一个主要目的是将来自 不同领域分享钙和细胞功能的最新和最令人兴奋的发展，目的是 跨学科共享信息，建立新的个人联系，促进未来的合作，以及 促进生物医学研究的多样性、公平性和包容性。2023年会议的联合主席将是 Mohamed Trebak博士(匹兹堡大学)和周宇斌博士(德克萨斯A&M大学)，以及Jen博士 刘和伊利亚·贝兹普罗兹万尼(德克萨斯大学西南医学中心)，他们都是公认的领导者 在钙信号领域。该方案包括九次科学会议、一次主旨演讲和三次 特别辅导课程。演讲的很大一部分将集中在分子和细胞基础上。 心血管疾病。将有36名会议发言者进行全面演讲，其中包括16名妇女(44% 发言者)和9名会议主席(其中5名为女性，占56%)。大多数被邀请的演讲者还没有介绍 在之前的会议期间，在这次会议上。我们还预留了谈话时段，以鼓励及早参与 职业生涯研究人员和科学界代表性不足的少数群体成员，他们的人数将 在9个简短的演讲中得到支持，从提交的摘要中选出。会场内有适当的 为残障人士提供的设施。本次会议所涉及的主题和主题将是及时和高度的 适用于广大科学家、临床医生和普通公众。

Project Summary This is an application for partial support of the FASEB Science Research Conference (SRC) on Calcium and Cell Function, which will be held from June 24th – June 29th 2023 in Lisbon, Portugal. The objective of this conference is to stimulate discourse, seed new ideas, and inspire collaborations to accelerate new discoveries on calcium signaling at the basic and translational levels. Calcium is regarded as a signal for life and death, arguably one of the most ubiquitous second messengers in biology that plays indispensable roles in a myriad of biological processes, ranging from heart beating, vascular tone, muscle contraction, synaptic transmission, development, gene expression, cell migration and immune response. Defects in the calcium signal handling machinery can lead to a large number of serious diseases, including neurological disorders, immunodeficiencies, developmental defects and cardiovascular disorders (hypertension, stroke, and cardiac arrhythmia). Because of this extreme diversity of functions and pathologies, researchers working in the calcium signaling tend to present their work at different meetings with little overlap, even though there are many common mechanisms, approaches, and insights into calcium signaling that transcend these boundaries. To address this, a primary purpose of this biennial FASEB SRC is to bring together leading investigators from a diversity of fields to share the latest and most exciting developments in Calcium and Cell Function, with the aim of sharing information across disciplines, establishing new personal contacts, fostering future collaborations, and promoting diversity, equity and inclusion in biomedical research. The co-chairs of the 2023 conference will be Drs. Mohamed Trebak (University of Pittsburgh) and Yubin Zhou (Texas A&M University), as well as Drs. Jen Liou and Ilya Bezprozvanny (University of Texas Southwestern Medical Center), who are all recognized leaders in the calcium signaling field. The Program consists of nine scientific sessions, one keynote address and three special mentoring sessions. A significant portion of talks will focus upon the molecular and cellular basis of cardiovascular diseases. There will be 36 session speakers giving full talks, including 16 women (44% of speakers) and 9 session chairs (5 of whom are women, 56%). Most of the invited speakers have not presented at this conference during prior meetings. We also reserved talk slots to encourage the participation of early career stage investigators and members of under-represented minorities in science, the numbers of which will be bolstered in 9 short talks to be selected from submitted abstracts. The conference venue has appropriate facilities for disabled attendees. The topics and themes covered in this conference will be timely and highly relevant for a broad population of scientists, clinicians, and the general public.