2023 Lung Development, Injury and Repair Gordon Research Conference and Gordon Research Seminar

项目摘要： 2023年肺发育，损伤和修复戈登研究会议（GRC）和相关的戈登 研究研讨会（GRS）将于2023年8月12日至18日在沃特维尔谷，NH举行。2023年的主题 肺GRC是“COVID后恢复呼吸健康”。2023年Lung GRC恰逢关键时刻， 因为包括严重肺损伤的慢性后果在内的急性COVID-19综合征将到来 聚焦，提高我们的需要，以了解和打击功能失调的修复和重塑， 严重受伤后。根据世界卫生组织的统计，全球肺负担 疾病继续上升，全世界每年有超过400万人死于慢性呼吸道疾病， 包括COPD、哮喘和肺纤维化。在基础科研取得长足进步的同时 在理解分子、细胞和组织水平上驱动呼吸系统疾病的机制方面取得了进展， 这些发现有助于早期发现和有效修复和恢复肺功能， 慢性呼吸道疾病仍然是一个主要障碍。应对这一挑战需要将以下方面结合起来： 来自肺发育、分子和细胞生物学、基因组学和表观基因组学专家的知识， 生理学，生物工程，基质生物学以及沉浸在 诊断和治疗人类疾病。Lung GRC/GRS 2023将汇集不同的专家， 传播和辩论肺发育，损伤和修复领域的最新发现，并制定 将生物学发现转化为有意义的进步的新想法、合作和方法 在呼吸内科。Lung GRC和GRS的一个主要重点是加强科学家的管道 临床医生专注于肺的发育、损伤和修复。R13中的资金将专门用于 促进妇女、代表人数不足的少数群体和残疾人参加会议， 研究生、博士后研究员和早期职业调查员。GRC的独特属性（开放 科学交流，隐蔽的位置，以最大限度地参与，传统，分享未发表的数据，丰富的 讨论时间）和GRS（学员与同行和导师的密切互动）提供了机会， 正式和非正式的互动和合作，可能会产生重大和持续的影响， 外地因此，2023年肺发育、损伤和修复GRC/GRS将促进以下方面的加速进展： 了解和治疗慢性肺部疾病，并有助于确保多样化的生命力和增长。 有能力解决日益增长的肺部疾病负担的临床医生和科学家的管道。

Project Summary: The 2023 Lung Development, Injury and Repair Gordon Research Conference (GRC) and associated Gordon Research Seminar (GRS) will be held August 12-18, 2023 in Waterville Valley, NH. The theme for the 2023 Lung GRC is "Post-COVID Return to Respiratory Health". The 2023 Lung GRC comes at a critical time, because post-acute COVID-19 syndrome including chronic consequence of severe lung injuries will be coming into focus, heightening our need to understand and combat the dysfunctional repair and remodeling that follows severe injury. According to statistics from the World Health Organization, the global burden of lung disease continues to rise, with >4 million deaths annually worldwide attributed to chronic respiratory diseases, including COPD, asthma, and pulmonary fibrosis. While basic scientific research is making substantial strides forward in understanding molecular, cellular and tissue level mechanisms driving respiratory diseases, translation of these findings toward early detection and effective repair and restoration of lung function in chronic respiratory diseases remains a major barrier. Meeting this challenge requires the integration of knowledge from experts spanning lung development, molecular and cell biology, genomics and epigenomics, physiology, bioengineering, matrix biology as well as physicians and translational experts immersed in the diagnosis and treatment of human disease. Lung GRC/GRS 2023 will bring diverse experts together to disseminate and debate the latest findings in the fields of lung development, injury and repair, and to formulate new ideas, collaborations and approaches that will translate biologic discoveries toward meaningful advances in respiratory medicine. A major emphasis of the Lung GRC and GRS is to strengthen the pipeline of scientists and clinicians focused on lung development, injury and repair. Funds from this R13 will be specifically targeted to promote participation in the conference by women, under-represented minorities and people with disabilities, graduate students, postdoctoral fellows, and early career investigators. The unique attributes of the GRC (open scientific exchange, secluded location to maximize engagement, tradition to share unpublished data, abundant time for discussion) and GRS (close trainee interactions with peers and mentors) provide an opportunity for formal and informal interactions and collaborations that are likely to have significant and sustained impact on the field. The 2023 Lung Development, Injury and Repair GRC/GRS will thus promote accelerated progress in understanding and treating chronic lung diseases, and help to ensure the vitality and growth of a diverse pipeline of clinicians and scientists capable of addressing the growing burden of lung diseases.