2023 Phagocytes Gordon Research Conference and Gordon Research Seminar

项目摘要/摘要 吞噬细胞戈登会议(GRC)和相关的戈登研究研讨会(GRS)将于6月举行 2023年3-9日，在密歇根州沃特维尔山谷。这将是该GRC的第22次迭代。吞噬细胞是一种具有 吞噬其他细胞或颗粒的能力。吞噬细胞包括免疫系统的细胞，如中性粒细胞， 单核/巨噬细胞，树突状细胞，苍蝇和蠕虫的类似细胞类型，“非经典”吞噬细胞 比如小胶质细胞和单细胞阿米巴。虽然吞噬细胞是免疫的中心，但它们也在组织中发挥作用。 动态平衡和发展。当调节失调时，吞噬细胞会导致显著的病理变化，包括 动脉粥样硬化、糖尿病、癌症、自身免疫和传染病。《2023年吞噬细胞》的主题 GRC是“宿主防御和炎症中的分子和细胞多样性”。它将成为全球最大的 分享吞噬细胞生物学中未发表的最新发现。专题包括吞噬细胞 分化和可塑性，迁移和吞噬机制，自噬和细胞死亡机制， 小胶质细胞和神经炎症，肿瘤中的吞噬细胞，宿主与病原体的相互作用，吞噬细胞串扰， 与微生物区系的相互作用，吞噬细胞生物学的技术创新。新奇的翻译 不同疾病中吞噬细胞的方法也将包括在内。与会者是国际领先的 细胞生物学、分子遗传学、微生物学、免疫学、生物工程和临床医学的科学家。 平均出席人数为148人。2022年(因新冠肺炎原因从2021年推迟)，52.3%的与会者 女性，55.4%是研究生或博士后。2023年的吞噬细胞GRC以13名女性为特色 11位男性特邀演讲者(54.2%为女性)，其中一位主讲人将发表他们令人兴奋的演讲 未发表的发现。37.5%的说话者认为自己是URM。九场会议将由讨论领袖主持 他们都是该领域的专家。与过去的GRC一样，16名初出茅庐的科学家(研究生、博士后、助理 教授)将根据提交的摘要被选作简短的演讲，另外16位教授将作简短的预演 他们的海报上。大约120张海报将在不与会谈重叠的会议中提交。至 加强学生和博士后的参与和专业发展，将进行GRS 就在GRC开始之前(6月3-4日)。由学员组织和主持的GRS是一个包容性的 为下一代吞噬细胞科学家分享他们的研究和建立社区提供了一个环境。一个 全面的多元化计划将确保与会者和演讲者来自不同的背景和 会议环境是包容和公平的。2023年的吞噬细胞GRC和GRS将作为纽带 分享吞噬细胞生物学方面未发表的前沿研究，从而促进交流和 研究吞噬细胞不同方面的研究人员之间的合作，提供了一个包容和 为实习生和年轻研究人员提供网络支持环境，并最终确定翻译 以及吞噬细胞在人类健康中的治疗靶点。

PROJECT SUMMARY/ABSTRACT The Phagocyte Gordon Conference (GRC) and associated Gordon Research Seminar (GRS) will be held June 3-9, 2023 at Waterville Valley, NH. This will be the 22nd iteration of this GRC. Phagocytes are cells that have the capacity to engulf other cells or particles. Phagocytes include cells of the immune system such as neutrophils, monocytes/macrophages, and dendritic cells, analogous cell types in flies and worms, “nonclassical” phagocytes like microglia, and single-celled amoeba. While phagocytes are central to immunity, they also play roles in tissue homeostasis and development. When dysregulated, phagocytes contribute to prominent pathologies including atherosclerosis, diabetes, cancer, autoimmunity, and infectious diseases. The theme of the 2023 Phagocytes GRC is “Molecular and Cellular Diversity in Host Defense and Inflammation.” It will be the premier forum for sharing the most recent unpublished discoveries in phagocyte biology. Featured topics include phagocyte differentiation and plasticity, mechanisms of migration and phagocytosis, autophagy and cell death mechanisms, microglia and neuroinflammation, phagocytes in cancer, host-pathogen interactions, phagocyte crosstalk, interaction with the microbiota, and technological innovations in phagocyte biology. Novel translational approaches for phagocytes in different diseases will also be covered. Attendees are leading international scientists in cell biology, molecular genetics, microbiology, immunology, bioengineering, and clinical medicine. The average attendance is 148 attendees. In 2022 (postponed from 2021 due to COVID-19), 52.3% of attendees were women and 55.4% were graduate students or postdocs. The 2023 Phagocytes GRC features 13 female and 11 male invited speakers (54.2% female), with one keynote speaker, who will present their exciting unpublished findings. 37.5% of speakers identify as URM. Nine sessions will be chaired by discussion leaders who are experts in the field. As in past GRCs, 16 early-career scientists (graduate students, postdocs, assistant professors) will be selected for short talks based on submitted abstracts, and another 16 will give a brief preview of their poster. Approximately 120 posters will be presented in sessions that do not overlap with the talks. To enhance the participation and professional development of students and postdocs, a GRS will take place immediately prior to the start of the GRC (June 3-4). Organized and chaired by trainees, the GRS is an inclusive environment for the next generation of phagocyte scientists to share their research and build community. A comprehensive Diversity Plan will ensure that attendees and presenters are from diverse backgrounds and the conference environment is inclusive and equitable. The 2023 Phagocytes GRC and GRS will serve as a nexus for sharing cutting-edge unpublished research in phagocyte biology, thereby facilitating communication and collaboration between investigators studying different aspects of phagocytes, providing an inclusive and supportive environment for trainees and young investigators to network, and ultimately identifying translational and therapeutic targets of phagocytes in human health.