RFA-CK-22-001, Investigation of Monkeypox and Other Zoonotic Diseases in the Democratic Republic of the Congo (DRC) - 2022

项目摘要 本项目的目标是提高科学认识，减少临床负担， 刚果民主共和国（DRC）的猴痘（MPX）和其他人畜共患疾病。这 应该直接支持美国疾病控制和预防中心加强公共卫生监测系统的使命 在全球范围内防止新出现的疾病的传播。这一项目将依靠金沙萨学校， 公共卫生部在培训公共卫生从业人员、开展科学研究、 研究试验，并支持刚果民主共和国卫生部实现其目标。该项目将 围绕刚果民主共和国基于实验室的MPX监测系统构建，以收集准确的病例负担 数据我们将通过评估卫生工作者的新培训方法来扩大这一框架， 改进地理数据，并在有新的诊断平台时进行评估。我们将用我们 与高度受影响地区的卫生系统建立关系，进行护理方案的临床试验， 疫苗和抗病毒疗法。我们将在高危人群和幸存人群中进行血清学调查， 更好地了解传播风险因素、病毒持久性和后遗症。我们将与关键群体合作， 在这些地区，以确定MPX的野生动物水库，并收集定性数据的态度， 生活在这些社区的关键人群的行为。我们将与刚果民主共和国政府合作， 通过预先培训应对工作人员，提高快速应对疫情的能力， 发展健康促进网络，并对错误信息迅速作出反应。我们将分享成果 与国家利益攸关方和其他有兴趣更好地准备应对地方性流行病的国家 和进口MPX盒

Project Summary The goals of this project are to improve the scientific understanding and reduce the clinical burden of Monkeypox (MPX) and other zoonotic diseases in Democratic Republic of the Congo (DRC). This should directly support the U.S. CDC mission of strengthening public health surveillance systems globally to prevent the spread of emerging diseases. This project will rely upon the Kinshasa School of Public Health’s considerable experience with training public health practitioners, conducting scientific research trials, and supporting the DRC Ministry of Health to accomplish its objectives. The project will be framed around a laboratory-based surveillance system for MPX in DRC to collect accurate case burden data. We will expand upon this framework by evaluating new training methods for health workers, improving geographic data, and assessing new diagnostic platforms when available. We will use our relationships with health systems in highly affected areas to conduct clinical trials of care regimens, vaccines, and anti-viral therapies. We will perform serosurveys in high-risk and survivor populations to better understand transmission risk factors, viral persistence, and sequalae. We will work with key groups in these areas to identify wildlife reservoirs of MPX and collect qualitative data on the attitudes and behaviors of key populations living in these communities. We will work with the government of DRC to improve the ability to respond to outbreaks quickly by preemptively training response workers, developing health promotion networks, and responding to misinformation rapidly. We will share results with national stakeholders and other nations interested in being better prepared for responding to endemic and imported MPX cases.