Biospecimen Core

Biosecimen core(BIO)：项目摘要 衰老的特征是分子和细胞损伤的积累，导致细胞数量减少 功能性。这种损害的程度和时间进程是一个不同的过程，因为 环境和遗传因素的复杂相互作用可以改善和/或加剧正常 衰老。哥伦比亚大学衰老组织图谱(CUSTMAP)的总体目标 中心的重点是关注易受年龄相关退化过程影响的关键器官系统；中心 神经系统和皮肤。这些系统之所以被选中，是因为它们代表了具有显著 适应/再生能力和异质细胞类型，将使我们能够研究局部影响 衰老对基因表达特征的影响及其对细胞组成和增长的影响 对与年龄有关的损伤和疾病的易感性。CUSTMAP中心的核心是始终如一 可获得表型良好的、高质量、未患病的人体组织，并已同意 广泛的数据共享。我们通过我们首屈一指的临床表型和 生物库资源。通过我们的Biosecimen Core(BIO)，我们将汇编最大的 多国队列的组织跨越寿命，具有可比较和可量化的临床 通过继续我们未来收集的表型相似的高质量病例， 爱丁堡大学和哥伦比亚大学欧文医学中心。我们的传记将汇集一位 领导团队来自不同的临床和研究背景，具有互补的成熟专业知识 在临床表型和组织生物库中。这个核心的目标不仅是为了与我们的生物 分析核心，以交付拟议目标的结果，但也要建立一个国际框架 表型组织库的标准化方法。我们希望通过建立这个框架， 将能够在这一领域开展更高质量的事前和事后、与人有关的研究。

BIOSPECIMEN CORE (BIO): PROJECT SUMMARY Aging is characterized by the accumulation of molecular and cellular damage resulting in decreasing cellular functionality. The extent and temporal progression of this damage is a heterogeneous process due to the complex interactions of environmental and genetic factors that can ameliorate and/or exacerbate normal aging. The overarching goal of the Columbia University Senescence Tissue Mapping (CUSTMAP) Center is to focus on key organ systems with vulnerability to age-related degenerative processes; the central nervous system and skin. These systems were selected as they represent organs with prominent adaptive/regenerative ability and heterogeneous cell types that will allow us to investigate the local effects of aging on gene expression signatures and how this impacts upon cellular composition and increase susceptibility to age-related damage and diseases. At the core of the CUSTMAP Center is consistent accessibility to well-phenotyped, high-quality, non-diseased human tissue that has been consented for broad data sharing. We are ideally positioned for this effort through our premier clinical phenotyping and biobanking resources. Through our Biospecimen Core (BIO), we will compile one of the largest multinational cohorts with tissues spanning the lifespan, with comparable and quantifiable clinical correlates, by continuing our prospective collection of comparably phenotyped high quality cases at both the University of Edinburgh and Columbia University Irving Medical Center. Our BIO will bring together a leadership team from diverse clinical and research backgrounds with complementary established expertise in clinical phenotyping and tissue biobanking. The aim of this core is not only to synergize with our Biological Analysis Core to deliver the outcomes of the proposed aims, but also to establish an international framework for a standardized approach to phenotypic tissue banking. Our hope is that by establishing this framework it will enable a higher quality of ante- and post-mortem, human-relevant research to be carried out in this field.