Promoting HPV Vaccination among Young Adults in Texas

项目总结 人类乳头瘤病毒(HPV)疫苗很重要，因为它可以预防HPV引起的癌症 感染。美国目前有近7900万人感染，约1400万人 每年都会感染HPV。HPV感染可导致女性和男性癌症， 在美国，这些与HPV相关的疾病每年造成的经济负担超过80亿美元。最多的 最近批准的HPV疫苗接种可以预防高达74%的HPV相关浸润性癌症。因此，人乳头瘤病毒 接种疫苗是当今癌症预防中最深刻的机会之一。美国疾病控制中心 控制和预防(CDC)建议在26岁之前接种HPV疫苗。在18-26岁的成年人中，HPV 疫苗接种完成率低得令人无法接受，而人乳头状瘤病毒感染率高得令人无法接受。还有就是 缺乏干预措施来提高未接种HPV疫苗的年轻人的疫苗接种率 童年。在接种HPV疫苗方面，男性的接种率低得不成比例，少数民族的接种率低得不成比例。 与非西班牙裔白人相比，完成疫苗接种的比率更低。这项研究旨在填补 通过使用2×3析因设计来测试多水平的独立和组合效应 干预：以学校为基础的HPV疫苗管理(无访问权限与访问权限)在系统级别和网络- 基于个人层面的叙述(无访问权限与视频与书面)。 这种干预是基于试点研究和社会生态模型开发的，这些模型认识到 对行为有多个层次的影响。2×3析因设计结果分为六组：) 关于HPV疫苗接种的标准疾控中心信息(对照)；2)关于HPV疫苗接种的视频解说；3) 关于HPV疫苗接种的书面叙述；4)在学校与标准疾病预防控制中心结合使用HPV疫苗 信息，5)在学校获得HPV疫苗并结合视频讲述，或6)获得HPV疫苗 在学校与书面叙述相结合。这种设计使我们能够独立和结合地调查 量身定做的叙述和基于学校的疫苗获取对HPV疫苗接种的影响。18岁的大学生-- 26名以前没有接种过HPV疫苗的人将被随机分配到六组中的一组。主要 结果是分别在3个月和9个月的随访中启动和完成HPV疫苗接种。这项研究有 通过启发未来新的研究方向来创造HPV疫苗接种的新范式的意义 包括改善HPV疫苗接种的多个层面的影响。这项研究将产生重大的积极意义 对公共卫生的影响，因为它正在使用为18-26岁的年轻人量身定做的循证战略，以 推动人乳头状瘤病毒疫苗接种“赶超”。如果成功，基于网络的干预可以很容易地传播 因为它简短且可伸缩。以学校为基础的HPV疫苗接种可在#年的大学校园内实施 改善医疗保健服务的未来。这项研究的成功和经验教训将为未来提供参考 为不同的社会群体量身定做叙事信息的策略。

Project summary Human papillomavirus (HPV) vaccine is important because it protects against cancers caused by HPV infection. Nearly 79 million people are currently infected in the United States and about 14 million people become infected with HPV each year. HPV infection can cause cancers in both women and men and the financial burdens of these HPV-related diseases cost more than $8 billion per year in the US. The most recently approved HPV vaccination can prevent up to 74% of HPV-associated invasive cancers. Thus, HPV vaccination is one of the most profound opportunities in cancer prevention today. The Centers for Disease Control and Prevention (CDC) recommends HPV vaccines through age 26. Among adults18–26 years, HPV vaccination completion is unacceptably low whereas HPV infection rates are unacceptably high. There is also a lack of interventions to improve HPV vaccination rates among young adults who were not vaccinated during childhood. In the area of HPV vaccination uptake, males have disproportionately low rates and minorities have lower rates of completing the vaccinations compared to non-Hispanic whites. This study aims to fill in the important gaps by using a 2 by 3 factorial design to test the independent and combined effects of a multilevel intervention: school-based HPV vaccine administration (no access vs. access) at the system level and web- based narratives (no access vs. video vs. written) at the individual level. This intervention is developed based on pilot studies and socio-ecological models that recognize the impact multiple levels of influence have on behaviors. The 2 by 3 factorial design results in six groups: ) standard CDC information about HPV vaccination (control); 2) video narratives about HPV vaccination; 3) written narratives about HPV vaccination; 4) access to HPV vaccine at school combined with standard CDC information, 5) access to HPV vaccine at school combined with video narratives, or 6) access to HPV vaccine at school combined with written narratives . This design allows us to investigate the independent and combined effects of tailored narratives and school-based vaccine access on HPV vaccination. College students aged 18- 26 who are not previously vaccinated against HPV will be randomly assigned to one of the six groups. Primary outcomes are HPV vaccine initiation and completion at 3- and 9-month follow-ups, respectively. This study has implications for creating a new paradigm in HPV vaccination by inspiring future new research directions that include multiple levels of influence to improve HPV vaccinations. This study will make a significant positive impact on public health, as it is using evidence-based strategies tailored for young adults aged 18-26 years to promote “catch up” HPV vaccination. If successful, the web-based intervention can be easily disseminated because it is brief and scalable. School-based HPV vaccinations can be implemented on college campuses in the future to improve healthcare delivery. Success and lessons learned in this study will inform future strategies to develop tailored narrative messages for different social groups.