Administrative Core

项目摘要--行政核心(核心A) 管理核心协调业务、计划和组织事项，并促进科学 项目和核心之间的协作以及与外部咨询委员会的定期会议 (东区议会)。主任和协理主任以及项目和核心领导执行委员会， 负责项目的日常领导工作。选管会就科学和技术问题提供长期指导 组织事务。虽然生酮饮食有益机制的研究有可能取得进展 和Shc耗尽在单个实验室中受益，更有可能的是，对 机制和生物标记物将通过汇集该领域的一批专家来实现，从而 使用几种不同的技术产生协作分析，并在生物学的多个层面上工作 组织。该计划项目的跨学科和国际性将需要 发挥行政核心的组织领导作用，进一步支持项目间的相互促进。 该计划的首要假设是：持续的、间歇性的和补充驱动的治疗 酮病延长功能寿命并改善阿尔茨海默病“。其目的包括：1)提供 协调研究和促进互动的结构；2)监测和定期审查 研究和准备进度报告；3)管理计划项目的财务部分；4)促进 出版、介绍和传播研究成果；5)组织项目年度会议 成员和外部审查委员会；以及6)协调和监测数据和资源共享， 包括米兰-戴维斯的资源转会。总体而言，行政核心提供了组织能量和 用于协同理解生酮的功能保存和长寿益处的结构 饮食，酮体仿制，和Shc抑制。作为我们成功的一个例子，我们提供了一个最近出版的 细胞代谢证明等卡路里生酮饮食延长了老年大鼠的生命功能和寿命 老鼠。这需要认识到我们发现的新颖性，重新定位资源，并将 适当的合作者展示一种有效的延长寿命的新机制，可能会 对人类具有显著的可译性。

Project Summary – Administrative Core (Core A) The Administrative Core coordinates business, scheduling, and organizational matters, and facilitates scientific collaborations among the projects and cores, and regular meetings with the External Advisory Committee (EAC). The Director and Associate Director, along with an Executive Committee of Project and Core Leaders, provide day-to-day leadership of the program project. EAC provides long-term guidance on scientific and organizational matters. Although it is possible to make progress on the mechanism of the ketogenic diet benefit and Shc depletion benefit in single laboratories, it is much more likely that an integrative understanding of mechanism and biomarkers will be achieved by bringing together a cohort of experts in the field, thereby producing a collaborative analysis using several different techniques and working at multiple levels of biological organization. The interdisciplinary and international nature of this Program Project will require strong organizational leadership from the Administrative Core to further support the cross-fertilization among projects. The overarching hypothesis of the Program is "Continuous, intermittent, and supplement-driven therapeutic ketosis extends functional longevity and ameliorates Alzheimer's disease". The aims include: 1) provide structure to coordinate research and promote interactions; 2) monitor and regularly review the quality of research and prepare progress reports; 3) manage the fiscal components of the Program Project; 4) facilitate publications, presentations, and the dissemination of research results; 5) organize annual meetings of project members and an external review committee; and 6) coordinate and monitor data and resource sharing, including Milan-Davis resource transfers. In total, the Administrative Core provides the organizing energy and structure for a synergistic understanding of the functional preservation and longevity benefits of the ketogenic diet, and ketomimetics, and of Shc inhibition. We provide as an example of our success a recent publication in Cell Metabolism that demonstrates the isocaloric ketogenic diet extends late-life functions and longevity in mice. This required recognition of the novelty of our findings, repositioning of resources, and putting together the appropriate collaborators to demonstrate an impactful new mechanism of lifespan extension that may have significant translatability to humans.