Admin Core

项目摘要(管理核心) 这一新的应用旨在继续研究罕见的嗜酸性胃肠道疾病(EGID) 重点关注嗜酸性食管炎(EoE)、嗜酸性胃炎(EG)、嗜酸性胃肠炎(EGE)和 嗜酸性结肠炎(EC)通过嗜酸性胃肠道疾病研究联盟(CEGIR)。 CEGIR的目标是促进高度协作、多地点、以患者为中心、转化和临床研究 解决未满足的临床试验准备需求的意图。虽然仍处于相对早期的阶段，但CEGIR 通过调查人员之间的协作互动展示成功(在职业生涯的所有阶段 发展)，积极主动的患者倡导团体(PAG)，以及NIH的合作机构，并已 成为专注于罕见EGID的领先临床和研究小组。CEGIR管理核心 旨在有效地生成和管理与以下各项相关的政策、程序、沟通和资金 CEGIR，并确保在包括科学在内的所有层面上达到最高水平的严谨性。CEGIR 行政核心将在协调决策和执行以实现目标方面不可或缺 CEGIR的。CEGIR的行政核心将包括CEGIR主任(首席调查员)、临床试验 联络，以及CEGIR内部指导委员会。CEGIR内部指导委员会将由 在现场领导人中，PAG代表[即美国嗜酸性粒细胞疾病伙伴关系(APFED)， 敦促研究嗜酸性粒细胞疾病(治愈)的运动，嗜酸性粒细胞家庭联盟(EFC)]，以及 行政协调员。CEGIR行政核心的具体活动包括但不限于 以下内容：1)制定和管理研究政策；2)管理和监测预算和资金 分发；3)为CEGIR核心和委员会提供监督和指导；4)审查和分发 CEGIR核心和委员会向适当受众(例如，利益攸关方)提交的报告和会议记录；5) 根据美国国立卫生研究院(NIH)的指导方针和指令传播网络信息；6) 吸收外部咨询委员会(EAC)的宝贵见解；以及7)促进一体化和伙伴关系 与PAGS、其他罕见疾病研究联盟和利益攸关方，包括国际联络机构。这个 管理核心将管理CEGIR的运营，确保CEGIR以高效、 富有成效的、成功的举止。

Project Summary (Administrative Core) This renewal application aims to continue research on rare eosinophilic gastrointestinal diseases (EGIDs) with a focus on eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC) through the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). CEGIR aims to promote highly collaborative, multi-site, patient-centric, translational and clinical research with the intent of addressing unmet clinical trial readiness needs. Though still in a relatively early stage, CEGIR is demonstrating success via its collaborative interactions between investigators (at all stages of career development), proactive patient advocacy groups (PAGs), and partnering institutions at the NIH and has emerged into the leading clinical and research group focused on rare EGIDs. The CEGIR Administrative Core aims to effectively generate and administer the policies, procedures, communications, and funds associated with CEGIR and ensure that the highest level of rigor, at all levels including scientific, is achieved. The CEGIR Administrative Core will be integral in coordinating decision-making and implementation to achieve the objectives of CEGIR. The CEGIR Administrative Core will include the CEGIR Director (Principal Investigator), Clinical Trial Liaison, and the CEGIR Internal Steering Committee. The CEGIR Internal Steering Committee will be composed of the Site Leaders, PAG representatives [i.e., American Partnership for Eosinophilic Disorders (APFED), Campaign Urging Research for Eosinophilic Diseases (CURED), Eosinophilic Family Coalition (EFC)], and Administrative Coordinators. Specific activities of the CEGIR Administrative Core include but are not limited to the following: 1) generate and administer research policies; 2) administer and monitor budgets and fund distribution; 3) provide oversight and guidance for CEGIR Cores and Committees; 4) review and distribute reports and proceedings from CEGIR Cores and Committees to appropriate audiences (e.g., stakeholders); 5) disseminate web-based information as per National Institutes of Health (NIH) guidelines and directives; 6) integrate valuable insight from the External Advisory Committee (EAC); and 7) foster integration and partnership with PAGs, other Rare Diseases Research Consortia, and stakeholders, including international liaisons. The Administrative Core will manage CEGIR operations ensuring that CEGIR achieves its goals in efficient, productive, and successful manners.