The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM)Research Core - Methods

项目总结：方法核心（C） 在我们作为D-ARC核心的成功基础上，在向完整ARC的过渡中，我们将扩大我们的 统计分析技术、研究设计、定性方法、心理健康方面的服务和培训 (MH)测量和数据管理。由于CHARM的主题与减少MH的影响有关， 和少数民族的健康差距在艾滋病毒预防和护理连续a，我们专注于多层次的方法。 MH合并症本质上是个体水平的过程。相比之下，MH和少数民族的健康差距 由存在于各个层面的更高层次的结构性社会文化进程驱动（例如，邻里关系， 城市，地区），其中个人嵌套。因此，中心的干预措施和方法 调查人员可能既处理个人问题，也处理社会文化问题，因此是多层次的。 方法核心负责促进科学研究设计（统计 方法和定性方法），通过多层次研究中的磋商， 实施符合CHARM目标循证实践。实现这一目标的活动包括 为MH-HIV研究人员提供咨询，制定赠款提案（以及奖后支持）， 支持早期研究人员与CHARM发展核心奖计划的研究领域， 研究设计，HIV及其合并症的生物标志物的使用，以及分析策略。 为了优化CHARM研究人员之间在MH-HIV研究方面的资源共享和合作， 方法Core将扩展统一的数据架构、集中的数据存储库，并跨核心进行协作 在一个乐器库里自愿性统一数据架构包括共同数据要素， 协作和合作项目，利用CHARM数据的方式不可能在单一的研究。核心 还维护由心理健康差异实施的同意联系数据库的数据库 和社区参与核心和CHARM REDCap措施库， 工具;包括西班牙语和海地克里奥尔语的措施，有关艾滋病毒和MH的结构。 最后，方法核心提供了对CHARM资源的分类访问， 方法讲习班和其他能力建设活动的重点是解决在艾滋病毒方面的生殖健康差距。 通过CHARM研究导航门户，研究者和社区合作伙伴可以协调 访问所有CHARM资源，方法咨询和以方法为重点的研讨会，内容包括 机器学习，可重复性，多级建模，以地理为重点的分析，交叉性， 人口之间的可靠性和有效性，以及模型选择方法。核心还促进了 来自其他CHARM核心和附属研究小组的咨询和演讲，如CFAR， CTSI、NIDA的国家药物滥用治疗临床试验网络和NIDA的P30 CHERISH中心， 它侧重于成本效益分析。

PROJECT SUMMARY: METHODS CORE (C) Building off our success as a Core in the D-ARC, in this transition to a Full ARC, we will expand upon our services and training in statistical analysis techniques, research design, qualitative approaches, mental health (MH) measurement, and data management. Because of CHARM’s theme related to reducing the impact of MH and minority health disparities across the HIV prevention and care continua, we focus on multi-level methods. MH comorbidities are inherently individual-level processes. In contrast, MH and minority health disparities are driven by higher-level structural socio-cultural processes that exist at the various levels (e.g., neighborhoods, cities, regions) within which individuals are nested. Therefore, interventions and approaches of Center investigators are likely to address both individual and socio-cultural processes and, thus, be multi-level. The Methods Core is responsible for promotion of state-of-the-science research design (statistical methods and qualitative approaches) via consultation in multi-level research that will inform local implementation of evidence-based practice consistent with CHARM goals. Activities to address this aim include providing consultation to MH-HIV researchers developing grant proposals (as well as post-award support) and supporting early-stage investigators with CHARM Developmental Core Awards Program studies in the areas of research design, use of biomarkers of HIV and its comorbidities, and analytic strategies. To optimize resource-sharing and collaboration on MH-HIV research among CHARM investigators, the Methods Core will expand a unified data architecture, centralized data repository, and collaborate across cores on an instrument library. The voluntary unified data architecture includes common data elements to facilitate collaboration and cooperative projects to utilize CHARM data in ways not possible in single studies. The Core also maintains databases for both consent-to-contact databases implemented by the Mental Health Disparities and Community Engagement Core and the CHARM REDCap Measures Library of well-established validated instruments; including Spanish and Haitian Creole-language measures of constructs relevant to HIV and MH. Finally, the Methods Core provides triaged access to CHARM resources, state-of-the-science methodology workshops, and other capacity-building activities focused on addressing MH disparities in HIV. Via the CHARM Research Navigation Portal, investigators and community partners are provided coordinated access to all CHARM resources, methodology consultations, and methods-focused workshops with content on machine learning, reproducibility, multilevel modelling, geographically-focused analysis, intersectionality, reliability and validity across populations, and model selection approaches. The Core also facilitates consultations and presentations from other CHARM Cores and affiliated research groups, such as the CFAR, CTSI, NIDA’s National Drug Abuse Treatment Clinical Trials Network, and NIDA’s P30 CHERISH Center, which focuses on cost-effectiveness analysis.