The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

项目摘要/摘要 候选人：我的首要目标是通过独立高质量的睡眠来促进健康的衰老 护士兼科学家。我在老年病学和行为睡眠医学方面的临床培训和我的临床预科 在睡眠和昼夜节律紊乱方面的研究为我的专业知识达到这一目标奠定了基础。这 提案将允许将基础科学方面的培训应用于人类研究，以支持对 老年人睡眠不良和认知障碍的分子机制及其潜在原因 互动。这份申请书中提出的职业发展将促进我作为一名新兴职业的成长 来自代表人数不足的背景的领导者，之前获得睡眠研究学会和 美国睡眠医学学会。 导师和环境：为此已经组建了一个由导师和顾问组成的知名团队 项目。我的主要导师布鲁斯·特罗恩博士(老年病学)是一位国际公认的老年病医生， 老年科学家。他将得到共同导师丽贝卡·洛伦茨博士(护理、老年、睡眠)的帮助。 Brienne Miner(老年病学，睡眠)，Kenneth Seldeen博士(老年病学，生物化学)； Nikhil Satchidanand(老年病学，认知)和马昌星博士(生物统计学)。我们已经创建了一个 以布法罗大学和耶鲁大学为基础的培养研究和领导技能的培训计划 老年医学和睡眠研究的大学课程，以促进职业发展的成功实施 并对本申请中概述的项目进行研究。 导师研究项目：睡眠质量差和睡眠时间短与认知能力有关 老年人的损害，可能是阿尔茨海默病和其他疾病的候选机制 线粒体功能受损和/或脑源性神经营养因子表达减少所致的痴呆 因子(BDNF)。我们之前的工作表明，提高烟酰胺腺嘌呤的利用率 二核苷酸(NAD+)可改善衰老小鼠的体能和认知能力，并可能降低 提高线粒体功能和增强脑源性神经营养因子对认知功能减退和睡眠质量的支持 表情。我们建议建立在退伍军人管理局资助的随机临床试验的基础上，调查 补充NAD+前体，烟酰胺核苷，维生素B3的一种形式，在身体上 老年人的表现，通过检查NR对睡眠质量、客观睡眠持续时间、 以及老年人的认知能力。为了实现这些目标，我们将评估睡眠质量、客观睡眠和 认知功能，以及检测接受为期三个月的治疗的参与者的血清BDNF水平 补充NR或安慰剂。这项提议将确认天然橡胶作为一种低风险和 对健康睡眠和优化认知功能的低成本干预。

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project. My primary mentor, Dr. Bruce Troen (Geriatrics) is an internationally recognized geriatrician and geroscientist. He will be assisted by co-mentors Dr. Rebecca Lorenz (Nursing, Geriatric, Sleep), Dr. Brienne Miner (Geriatrics, Sleep), Dr. Kenneth Seldeen (Geriatrics, Biochemistry); and advisors Dr. Nikhil Satchidanand (Geriatrics, Cognition), and Dr. Chang-Xing Ma (Biostatistics). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successul execution of the career development and reseach project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose to build upon a VA-funded randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, upon physical performance in older adults, by examining the benefits of NR on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three-month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.