The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

烟酰胺核苷对老年退伍军人认知和睡眠的益处

• 批准号: 10835339
• 负责人: Carleara Weiss
• 金额: $ 7.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10835339
• 关键词: Academy; Administrative Supplement; Adult; Alzheimer' s Disease; American; Amyloid beta-42; Applied Research; Award; Basic Science; Behavioral; Biological Markers; Biometry; Brain-Derived Neurotrophic Factor; Childbirth; Circadian Dysregulation; Clinical; Clinical Sciences; Cognition; Collaborations; Consent; Consultations; Data; Data Analyses; Data Collection; Dementia; Discipline of Nursing; Elderly; Elements; Ensure; Environment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Exhibits; Fees; Fellowship; Foundations; Geriatrics; Goals; Growth; Healthcare; Hippocampus; Human; Human Resources; Impaired cognition; Impairment; Institutional Review Boards; Intervention; K-Series Research Career Programs; Leadership; Measures; Medical center; Medicine; Memory; Memory impairment; Mentors; Mentorship; Mitochondria; Molecular; Mus; Niacinamide; Nicotinamide adenine dinucleotide; Nurses; Participant; Phase; Physical Performance; Pittsburgh Sleep Quality Index; Placebos; Pregnancy Complications; Productivity; Psyche structure; Questionnaires; Recovery; Research; Research Assistant; Research Design; Research Project Grants; Resources; Risk; School Nursing; Scientist; Secure; Serum; Services; Severities; Sleep; Sleep disturbances; Sleeplessness; Societies; Statistical Data Interpretation; Supplementation; Synaptic plasticity; Time; Training; Training Programs; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Wages; Work; aged; career development; clinical development; clinical training; cognitive function; cognitive testing; data management; empowerment; executive function; experience; fitbit; functional outcomes; graduate student; healthy aging; human old age (65+); improved; improvement on sleep; indexing; intervention cost; mild cognitive impairment; nicotinamide riboside supplementation; nicotinamide-beta-riboside; patient screening; placebo group; placenta previa; poor sleep; pre-clinical; preservation; prevent; programs; randomized, clinical trials; screening; skills; sleep pattern; sleep quality; tau-1; undergraduate student; wearable device

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project composed of Dr. Rebecca Lorenz (Primary Mentor, Nursing, Geriatric, Sleep), Dr. Brienne Miner, (Geriatrics, Sleep), and Dr. M. Jeffery Mador (Sleep, Veteran Healthcare). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successful execution of the career development and research project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose a randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three- month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.

项目摘要/摘要 候选人：我的首要目标是通过独立高质量的睡眠来促进健康的衰老 护士兼科学家。我在老年病学和行为睡眠医学方面的临床培训和我的临床预科 在睡眠和昼夜节律紊乱方面的研究为我的专业知识达到这一目标奠定了基础。这 提案将允许将基础科学方面的培训应用于人类研究，以支持对 老年人睡眠不良和认知障碍的分子机制及其潜在原因 互动。这份申请书中提出的职业发展将增强我作为一名 从代表不足的背景中脱颖而出的领导者，此前曾获得睡眠研究奖 学会和美国睡眠医学学会。 导师和环境：为此已经组建了一个由导师和顾问组成的知名团队 项目由Rebecca Lorenz博士(初级导师，护理，老年，睡眠)，Brienne Miner博士， (老年病学，睡眠)和M.Jeffery Mador博士(睡眠，老兵医疗)。我们已经创建了一个培训 基于布法罗大学和耶鲁大学的研究和领导技能培养计划 关于老年病学和睡眠研究的大学课程，以成功地执行职业发展 和本申请表中概述的研究项目。 导师研究项目：睡眠质量差和睡眠时间短与认知能力有关 老年人的损害，可能是阿尔茨海默病和其他疾病的候选机制 线粒体功能受损和/或脑源性神经营养因子表达减少所致的痴呆 因子(BDNF)。我们之前的工作表明，提高烟酰胺腺嘌呤的利用率 二核苷酸(NAD+)可改善衰老小鼠的体能和认知能力，并可能降低 提高线粒体功能和增强脑源性神经营养因子对认知功能减退和睡眠质量的支持 表情。我们建议进行一项随机临床试验，研究补充剂 NAD+前体，烟酰胺核苷，维生素B3的一种形式，对睡眠质量、客观睡眠时间、 以及老年人的认知能力。为了实现这些目标，我们将评估睡眠质量，客观睡眠 和认知功能，以及检测接受三次治疗的参与者的血清BDNF水平。 每月补充NR或安慰剂。这项提案将确认NR作为一种低风险药物的潜力 以及对健康睡眠和优化认知功能的低成本干预。