The benefits of nicotinamide riboside upon cognition and sleep in older Veterans

烟酰胺核苷对老年退伍军人认知和睡眠的益处

• 批准号: 10835339
• 负责人: Carleara Weiss
• 金额: $ 7.53万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10835339
• 关键词: Academy; Administrative Supplement; Adult; Alzheimer' s Disease; American; Amyloid beta-42; Applied Research; Award; Basic Science; Behavioral; Biological Markers; Biometry; Brain-Derived Neurotrophic Factor; Childbirth; Circadian Dysregulation; Clinical; Clinical Sciences; Cognition; Collaborations; Consent; Consultations; Data; Data Analyses; Data Collection; Dementia; Discipline of Nursing; Elderly; Elements; Ensure; Environment; Enzyme-Linked Immunosorbent Assay; Epidemiology; Exhibits; Fees; Fellowship; Foundations; Geriatrics; Goals; Growth; Healthcare; Hippocampus; Human; Human Resources; Impaired cognition; Impairment; Institutional Review Boards; Intervention; K-Series Research Career Programs; Leadership; Measures; Medical center; Medicine; Memory; Memory impairment; Mentors; Mentorship; Mitochondria; Molecular; Mus; Niacinamide; Nicotinamide adenine dinucleotide; Nurses; Participant; Phase; Physical Performance; Pittsburgh Sleep Quality Index; Placebos; Pregnancy Complications; Productivity; Psyche structure; Questionnaires; Recovery; Research; Research Assistant; Research Design; Research Project Grants; Resources; Risk; School Nursing; Scientist; Secure; Serum; Services; Severities; Sleep; Sleep disturbances; Sleeplessness; Societies; Statistical Data Interpretation; Supplementation; Synaptic plasticity; Time; Training; Training Programs; Translational Research; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Veterans; Wages; Work; aged; career development; clinical development; clinical training; cognitive function; cognitive testing; data management; empowerment; executive function; experience; fitbit; functional outcomes; graduate student; healthy aging; human old age (65+); improved; improvement on sleep; indexing; intervention cost; mild cognitive impairment; nicotinamide riboside supplementation; nicotinamide-beta-riboside; patient screening; placebo group; placenta previa; poor sleep; pre-clinical; preservation; prevent; programs; randomized, clinical trials; screening; skills; sleep pattern; sleep quality; tau-1; undergraduate student; wearable device

Project summary/ abstract Candidate: My overarching goal is to promote healthy aging through quality sleep as an independent nurse-scientist. My clinical training in geriatrics and behavioral sleep medicine and my pre-clinical fellowship in sleep and circadian disruptions lay the foundation for my expertise to reach this goal. This proposal will permit training in basic sciences applied to human studies to support the understanding of molecular mechanisms of poor sleep and cognitive impairment in older adults and their underlying interactions. The career development proposed in this application will empower my growth as an emerging leader from an underrepresented background with previous awards from the Sleep Research Society and American Academy of Sleep Medicine. Mentors and Environment: A prominent team of mentors and consultants has been assembled for this project composed of Dr. Rebecca Lorenz (Primary Mentor, Nursing, Geriatric, Sleep), Dr. Brienne Miner, (Geriatrics, Sleep), and Dr. M. Jeffery Mador (Sleep, Veteran Healthcare). We have created a training program to nurture research and leadership skills based upon the University at Buffalo and Yale University programs on geriatrics and sleep research for successful execution of the career development and research project outlined in this application. Mentored Research Project: Poor sleep quality and short sleep duration are associated with cognitive impairment in older adults and may be candidate mechanism underlying Alzheimer’s Disease and other dementias via impaired mitochondrial function and/or a reduced expression of brain-derived neurotrophic factor (BDNF). Our previous work indicated that enhancing the availability of nicotinamide adenine dinucleotide (NAD+) improves physical performance and cognition in aged mice and may reduce cognitive decline and support sleep quality by boosting mitochondrial function and enhancing BDNF expression. We propose a randomized clinical trial investigating the effects of supplementation with the NAD+ precursor, nicotinamide riboside, a form of vitamin B3, on sleep quality, objective sleep duration, and cognition in older adults. To accomplish these goals, we will assess sleep quality, objective sleep and cognitive function, as well as examine serum levels of BDNF of participants who receive a three- month supplementation with NR or placebo. This proposal will confirm the potential of NR as a low-risk and low-cost intervention for both healthy sleep and optimized cognitive function.

项目概要/摘要 候选人：我的首要目标是通过高质量的睡眠促进健康的老龄化，作为一个独立的 护士兼科学家我在老年病学和行为睡眠医学方面的临床训练， 在睡眠和昼夜节律紊乱方面的研究为我实现这一目标的专业知识奠定了基础。这 建议将允许在应用于人类研究的基础科学方面进行培训，以支持对 老年人睡眠不良和认知障碍的分子机制及其潜在的 交互.在此申请中提出的职业发展将使我的成长为一个 一位来自睡眠研究机构的代表性不足的背景的新兴领导者， 学会和美国睡眠医学学会。 导师和环境：为此组建了一个由导师和顾问组成的杰出团队 项目由Rebecca Lorenz博士（初级导师，护理，老年，睡眠），Brienne Miner博士， （老年医学，睡眠），和M。Jeffery Mador（睡眠，退伍军人保健）。我们创造了一种训练， 以布法罗大学和耶鲁大学为基础，培养研究和领导技能的计划 老年医学和睡眠研究大学课程，以成功执行职业发展 和研究项目概述在此应用程序。 指导研究项目：睡眠质量差和睡眠时间短与认知功能相关 老年人的损伤，可能是阿尔茨海默病和其他疾病的潜在机制 通过线粒体功能受损和/或脑源性神经营养因子表达减少 脑源性神经营养因子（BDNF）。我们以前的工作表明，提高烟酰胺腺嘌呤的可用性， 二核苷酸（NAD+）可改善老年小鼠的体能和认知能力， 通过增强线粒体功能和增强BDNF， 表情我们建议进行一项随机临床试验，调查补充维生素B1的效果。 NAD+前体，烟酰胺核苷，维生素B3的一种形式，对睡眠质量，客观睡眠时间， 和认知能力。为了实现这些目标，我们将评估睡眠质量，客观睡眠， 和认知功能，以及检查血清BDNF水平的参与者谁接受了三个- 月补充NR或安慰剂。该提案将确认NR作为低风险 以及低成本的健康睡眠和优化认知功能的干预。