Integrating prevention and treatment of non-communicable diseases and HIV care through research training in Kenya-INTEGRATE

摘要 这项申请旨在通过建立长期的肯雅塔来更新我们的D43艾滋病毒研究培训补助金 国立医院（KNH）与华盛顿大学（UW）的合作以及我们第一个10年的成功 在题为“通过实施科学改善肯尼亚的艾滋病护理级联”的赠款下进行培训 培训”。从2013年9月到现在，该计划的重点是提高研究能力， KNH，肯尼亚最大的教学和转诊医院，并在肯尼亚卫生部（MOH），以改善 艾滋病毒检测、与护理的联系、抗逆转录病毒启动和病毒抑制，这是一个被称为艾滋病毒护理的连续体 级联。随着肯尼亚艾滋病毒流行的演变，我们正在将重点转向预防和治疗非艾滋病毒感染者。 非传染性疾病，包括心血管和代谢疾病、慢性肺病、精神 艾滋病毒感染者（PLWH）的健康问题和癌症，使PLWH活得更长，更健康 生活在过去两个赠款期间，18名KNH护理级联（KNHCC）学员获得了MPH或博士学位 学位，这为KNH和我们在卫生部的合作伙伴继续提供关键的 支持实现这一愿景所需的培训、教学和研究活动。续期申请 将设在KNH，由KNH研究和项目部负责人John Kinuthia博士领导， Carey Farquhar博士，华盛顿大学全球卫生部临时主席。大多数 培训将在肯尼亚进行，KNH将是主要获奖者。题为“预防和治疗相结合 非传染性疾病和艾滋病毒护理的研究培训在肯尼亚-整合，”该计划将 通过实施科学和流行病学的MPH/博士课程提供长期培训， 包括在内罗毕大学（UoN）的博士培训（3年）和在西雅图的MPH培训（1年）。程序 还将在肯尼亚提供为期1年的博士后奖学金，以帮助博士生在发展过程中建立桥梁 独立研究和职业发展奖的建议。我们还将提供短期的亲自和 在肯尼亚进行在线培训，讲授为期1至2周的实施科学和其他研究方法课程 在过去的十年里，KNH成功地教授了这些知识。我们将利用UW全球部门 卫生部的电子学习平台（eDGH），以达到大量的KNH和卫生部的专业人员。短池 培训将建立更广泛的机构能力，并确定未来学位和职位的最佳候选人， 博士培训。由主要研究人员、教育工作者和公共卫生部门组成的指导委员会 来自所有4个机构（KNH、UoN、UW和MOH）的专业人员将与项目主任密切合作， 共同指导并定期接受外部培训咨询委员会（TAC）的意见，以确保 每个学员和整个计划。这一成功将转化为生产高质量和当地相关的 研究，培训下一代肯尼亚研究人员，并影响国家指导方针和政策， 预防和治疗艾滋病毒携带者中的非传染性疾病。

ABSTRACT This application seeks to renew our D43 HIV research training grant by building on longstanding Kenyatta National Hospital (KNH) collaborations with University of Washington (UW) and our first 10 years of successful training under the grant titled, “Improving the HIV Care Cascade in Kenya through Implementation Science Training”. From September 2013 to the present, the program has focused on increasing research capacity at KNH, the largest teaching and referral hospital in Kenya, and at the Kenya Ministry of Health (MOH) to improve HIV testing, linkage to care, antiretroviral initiation and viral suppression, a continuum known as the HIV care cascade. With evolution of the HIV epidemic in Kenya, we are shifting focus to preventing and treating non- communicable diseases (NCDs), including cardiovascular and metabolic disease, chronic lung disease, mental health problems, and cancer among people living with HIV (PLWH), to enable PLWH to live longer and healthier lives. During the last two grant periods, 18 KNH Care Cascade (KNHCC) trainees have earned MPH or PhD degrees and this provides a solid foundation for KNH and our partners at MOH to continue providing critical support for the training, teaching, and research activities needed to realize this vision. The renewal application will be based at KNH and led by Dr. John Kinuthia, Head of the Department of Research and Programs at KNH, and co-led by Dr. Carey Farquhar, Interim Chair of the Department of Global Health at UW. A majority of the training will take place in Kenya and KNH will be the prime awardee. Titled “Integrating prevention and treatment of non-communicable diseases and HIV care through research training in Kenya-INTEGRATE,” the program will offer long-term training through an MPH/PhD program in implementation science and epidemiology which includes PhD training at University of Nairobi (UoN) (3 years) and MPH training in Seattle (1 year). The program will also offer a 1-year mentored post-doctoral fellowship in Kenya to bridge PhD trainees as they develop proposals for independent research and career development awards. We will also offer short-term in-person and online training in Kenya, teaching 1 to 2-week courses on implementation science and other research methods that have been taught successfully at KNH over the last decade. We will leverage the UW Department of Global Health’s e-learning platform (eDGH) to reach large numbers of KNH and MOH professional staff. Short-course trainings will build broader institutional capacity and identify the best candidates for future degree and post- doctoral training. A Steering Committee comprised of leading researchers, educators, and public health professionals from all 4 institutions (KNH, UoN, UW, and MOH) will work closely with the Program Director and Co-director and receive regular input from an external Training Advisory Committee (TAC) to ensure success of each trainee and the overall program. This success will translate into producing high-quality and locally relevant research, training the next generation of Kenyan researchers, and influencing national guidelines and policies to prevent and treat NCDs among PLWH.