Understanding pathogen and host determinants of the natural history of N. gonorrhoeae infection

摘要： N.抗生素耐药性上升淋病对全球公共卫生构成严重威胁。 有效地控制了N.淋病受到无症状感染的阻碍， 细菌向未感染个体的传播以及细菌的免疫逃避， 疫苗研发工作有限。了解无症状的自然史 感染和负责清除感染的免疫应答。我们 建议进行一项密切监测的纵向研究，并对最近患有N. 淋病感染者再次感染的风险很高。本研究将提供丰富的数据 了解病原体暴露和感染结果。它还将提供一套生物 标本，以研究病原体和宿主因素，有助于感染清除以及 无症状携带和/或进展为有症状感染。我们会进行 抗N.淋病抗体和细胞免疫反应，以告知相关的 对淋病的保护性免疫该项目将提供重要的新 有助于公共卫生和疫苗开发工作的信息， 传播N.淋病

Abstract: Rising antibiotic resistance in N. gonorrhoeae poses a serious, global public health threat. Effective control of N. gonorrhoeae is hampered by asymptomatic infections that allow transmission of the bacteria to uninfected individuals and immune evasion by the bacteria that has limited vaccine development efforts. Understanding the natural history of asymptomatic infection and the immunologic responses that are responsible for clearance of infection. We propose a longitudinal study with close surveillance and of follow up individuals with recent N. gonorrhoeae infection who are at high risk for re-infection. This study will provide a rich data set to understand pathogen exposure and infection outcome. It will also provide a set of biologic specimens to study the pathogen and host factors that contribute to infection clearance as well as asymptomatic carriage and/or progression to symptomatic infection. We will conduct analysis of anti-N. gonorrhoeae antibody and cellular immune responses to inform correlates of protective immunity against gonorrhea. Combined this project will provide important new information that will contribute to public health and vaccine development efforts to reduce the spread of N. gonorrhoeae.