IU Training Program in Molecular Physiology and Clinical Mechanisms of Lung Disease

项目摘要/摘要 这项申请，目前已进入第10个年头，是一个竞争性的更新，在分子方面的培训计划 《肺部疾病的生理学和临床机制》，作为成人和 印第安纳大学儿科肺部研究-培训计划(CAPPRI)。该计划在以下方面独一无二 综合成人和儿童的肺分区，以检查整个生命周期内的疾病。我们的使命 是培养杰出的医学博士和博士科学家，让他们在调查职业生涯中发挥领导作用。为了定位未来 为了实现这一目标，我们的培训计划(CAPPRI)旨在使学员拥有全面的、 综合的、正式的职业发展经验，目标是将他们定位为下一个 肺和重症监护研究领域的新一代领导者。CAPPRI强调翻译科学， 结合最新的科学平台和与细胞、动物模型和人类相结合的教学培训 具有既定临床研究计划的组织研究。正规的研究生院培训可通过 印第安纳州临床和转化科学研究所(CTSI)。有33名教师导师和7名新兴教师 来自9个部门的导师。纳入7名新兴导师(EM)是为了提供以下连续的 CAPPRI的导师和领导力发展。CAPPRI是围绕选定的主题亲和力设计的 组(标记)。这五个标签包括：1)血管生物学，包括成人和儿童的陈述 疾病；2)结果和卫生服务；3)涵盖整个生命周期的呼吸道生物学；4) 炎症、损伤和修复；5)发育机制。对于可持续的员工队伍，我们将使用 以学术坚持性的概念模型为理论框架。2009-2019年间，22名T32学员 其中18人完成了培训。83.3%留在学术医学或相关研究领域。 该组织已经出版了147部同行评议的作品。该组织已获得25项奖助金，其中包括8项 奖学金奖，5个职业发展奖，3个NIH R01奖。受训人员非常多样化， 50%的女性。所有这些因素使印第安纳大学成为培养未来领导者的理想场所 呼吸道疾病横跨整个生命周期。

PROJECT SUMMARY / ABSTRACT This application, currently in the 10th year, is a competitive renewal of the “Training Program in Molecular Physiology and Clinical Mechanisms of Lung Disease”, which is implemented as a Combined Adult and Pediatrics Pulmonary Research-training program at Indiana University (CAPPRI). The program is unique in synthesizing the adult and pediatric Pulmonary Divisions to examine diseases across the lifespan. Our mission is to train exceptional MD and PhD scientists for leadership in investigative careers. In order to position the future generation for this goal, our training program (CAPPRI) is designed to enable Trainees to have a comprehensive, integrative, and formal career development experience with the goal of positioning them to become the next generation of leaders in Pulmonary and Critical Care research. The CAPPRI stresses translational science, incorporating the newest scientific platforms and didactic training integrated with cell, animal model, and human tissue research with established clinical research programs. Formal graduate school training is available through the Indiana Clinical and Translational Sciences Institute (CTSI). There are 33 Faculty Mentors and 7 Emerging Mentors from 9 Departments. The inclusion of 7 emerging mentors (EM) is to provide the continuum of mentorship and leadership development for the CAPPRI. CAPPRI is designed around selected Thematic Affinity Groups (TAGs). The five TAGs include: 1) Vascular Biology, including both adult and pediatric presentations of disease; 2) Outcomes and Health Services; 3) Airway Biology encompassing the continuum of the lifespan; 4) Inflammation, Injury and Repair; and 5) Developmental Mechanisms. For a sustainable workforce, we will use a conceptual model of academic persistence as our theoretical framework. Between 2009-2019, 22 T32 Trainees were supported, with 18 completing their training. 83.3% remain in academic medicine or related research fields. The group has published 147 peer-reviewed works. This group has been awarded 25 grants, including 8 fellowship awards, 5 career development awards, and 3 NIH R01 awards. The Trainees are highly diverse, with 50% women. All of these factors enable the Indiana University to be an ideal site for training future leaders in respiratory diseases across the lifespan.