Core 2: Biostatistics and Bioinformatics Core

项目摘要/摘要 生物统计和生物信息学核心(BBC)将通过以下方式促进前列腺癌的翻译研究 为加州大学洛杉矶分校的研究人员及其同事提供最先进的生物统计学、生物信息学和临床 试验支持。BBC为前列腺癌提供一个集中的生物统计和生物信息学支持网络 加州大学洛杉矶分校的癌症研究人员和他们的合作者。核心的总体目标是提供统计和 为孢子中的基础和临床研究人员提供生物信息支持。统计咨询将由以下人员领导 David Elashoff博士和李刚博士的支持下，将包括电力分析和咨询 临床前和临床研究计划的实验设计。核心将在开发方面进行合作 执行统计分析计划，并协助执行这些计划。生物信息学部门将领导 托马斯·格雷伯博士和保罗·布特罗斯博士的支持。核心为所有人提供分析服务 基因组学研究，包括RNA/整个外显子组/T细胞受体测序和蛋白质组学分析 孢子。对于这些数据类型，核心将协助数据预处理、管道开发和云计算 计算，质量控制评估，以及标准和定制的综合和网络分析。其核心是 将协助报告手稿中的研究成果。最后，生物统计学和生物信息学的核心 每年为所有孢子调查员提供教育研讨会和课程。

PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics Core (BBC), will facilitate translational research in prostate cancer, by providing UCLA investigators and their colleagues with state of the art biostatistical, bioinformatics and clinical trials support. The BBC provides a centralized network of biostatistics and bioinformatics support for prostate cancer researchers at UCLA and their collaborators. The overall goal of the Core is to provide statistical and bioinformatic support to basic and clinical investigators in the SPORE. The statistical consulting will be led by Dr. David Elashoff and supported by Dr. Gang Li and will include consultation on power analyses and experimental design for planning of preclinical and clinical studies. The core will collaborate on the development of statistical analysis plans and assist with carrying out those plans. The Bioinformatics component will be led by Dr. Thomas Graeber and supported by Dr. Paul Boutros. The Core provides analytical services for all genomics research, including RNA/whole exome/T-cell receptor sequencing and proteomic analysis within the SPORE. For these data types the core will assist with data preprocessing, pipeline development and cloud computing, quality control evaluation, and both standard and custom integrative and network analysis. The core will assist with the reporting of research findings in manuscripts. Finally, the Biostatistics and Bioinformatics Core provides yearly educational seminars and courses to all SPORE investigators.